Method for identifying spleen and stomach strengthening component in spleen-tonifying pill or spleen-tonifying pill oral liquid
A technology of oral liquid and Liushenqu, which is applied in the field of identification of Chinese patent medicines, can solve the problems of difficult identification, large discrepancy, and different dosage ratios of medicinal materials, and achieve the effect of improving quality and speeding up the method
Inactive Publication Date: 2019-06-07
广西壮族自治区食品药品检验所
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Problems solved by technology
The processing standards of each province or the standards of Chinese medicinal materials are recorded. The prescriptions all include flour, wheat bran, bitter almonds, red bean, Artemisia annua, Polygonum, and Xanthium, but the dosage ratio of each medicinal material is not the same. Big
There are many counterfeit products of Liushenqu, mainly due to cutting corners in production and processing, and mostly not adding bitter almonds and red bean raw materials. After these medicinal materials are fermented, their appearance is very similar to the genuine Liushenqu, and it is difficult to identify them. Unscrupulous traders often use this as a forgery The products pretend to be Liushenqu, illegally seek profits, and seriously affect the quality, curative effect and drug safety of Liushenqu
Due to the low content of amygdalin in the sample, it is more difficult to identify it using the general constant identification method
Method used
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Embodiment
[0029] Embodiment, content is as follows:
[0030] Instrument: high performance liquid chromatography system (including Agilent 1290 G4220B pump, 1290 G4226A autosampler 1290 column thermostat, Agilent Technologies, USA), mass spectrometer: Agilent 6460 tandem quadrupole mass spectrometer (Agilent Technologies, USA); BP211D Type electronic analytical balance (Sartorius, Germany); Milli-Q ultrapure water preparation instrument (Millipore, USA).
[0031] Reagents: acetonitrile (chromatographic grade, Merck), methanol (analytical grade, Sinopharm Chemical Reagent Co., Ltd.), formic acid (excellent grade, Tianjin Guangfu Fine Chemical Research Institute), ultrapure water (prepared by Milli-Q pure water system ), amygdalin (China Inspection Institute, batch number 110820-201607).
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Abstract
The invention discloses a method for identifying the spleen and stomach strengthening component in a spleen-tonifying pill or spleen-tonifying pill oral liquid. According to the identifying method, with amarogentin as a reference substance, whether a spleen-tonifying pill or spleen-tonifying pill oral liquid contains the amarogentin is detected by using the high performance liquid chromatography tandem mass spectrometry method and thus whether a spleen and stomach strengthening component feeding disqualification problem occurs in the spleen-tonifying pill or spleen-tonifying pill oral liquid is identified. With the high performance liquid chromatography tandem mass spectrometry method, whether the sample contains the amarogentin is identified rapidly, flexibly, and accurately. The establishment of the identification method for the spleen and stomach strengthening component has the important significance in improving the quality of the spleen and stomach strengthening component and controlling the feeding of the spleen and stomach strengthening component in the spleen-tonifying pill or spleen-tonifying pill oral liquid.
Description
technical field [0001] The invention relates to the technical field of identification of Chinese patent medicines, in particular to a method for identifying components of Liushenqu in Qipi Pills and Qipi Oral Liquid. Background technique [0002] Qipi pills (big honey pills) are made of ginseng, bran fried Atractylodes macrocephala, Poria cocos, licorice, tangerine peel, yam, lotus seeds (stir-fried), fried hawthorn, Liushenqu (stir-fried), fried malt, Alisma, etc. It is made by mixing refined honey. Qipi Pill (Water Pill) is composed of ginseng, bran fried Atractylodes macrocephala, Poria cocos, licorice, tangerine peel, yam, lotus seeds (stir-fried), fried hawthorn, Liushenqu (stir-fried), fried malt, Alisma, etc. Eleven medicinal powders, sieved , mixed evenly, pilled with water, polished and dried. Qipi Oral Liquid is composed of 11 herbs including ginseng, bran fried Atractylodes macrocephala, Poria cocos, licorice, tangerine peel, yam, fried lotus seeds, fried hawtho...
Claims
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IPC IPC(8): G01N30/02G01N30/06
Inventor 罗轶谢培德何颂华黄清泉冯枫燕霞罗永强
Owner 广西壮族自治区食品药品检验所