Odor masking formulations for natural compounds

A natural compound, odor masking technology, applied in odor masking preparations of odor compounds, chronic fatigue syndrome and menopause, hydrocolloid polymer and gum combination, treatment of attention deficit disorder, hydrocolloid polymer and gum field, can solve Issues such as unpleasant odor reproduction, insufficient formulation stability, complex masking, etc.

Inactive Publication Date: 2019-06-07
LAILA NUTRACEUTICALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, as far as the inventors are aware, there is no prior art available for masking the objectionable odor of extracts / fractions or pure compounds or nutraceuticals due to the relative complexity of masking compared to synthetic drugs
[0012] Furthermore, the techniques disclosed in the prior art for the synthesis of drugs have some inherent disadvantages, which include when the odor-masking product is subjected to various formulation processes (such as encapsulation, tableting, suspension or emulsion) and packaging and handling. Insufficient stability of formulations under certain physical stresses leading to unpleasant odor reappearance
In addition, these technologies also affect the stability and bioavailability of active substances

Method used

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  • Odor masking formulations for natural compounds
  • Odor masking formulations for natural compounds
  • Odor masking formulations for natural compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] The dried root (100 g) of the plant material Valeriana officinalis was pulverized into a coarse powder and extracted with ethanol (300 mL) at a temperature range of 65-70° C. for 2 hours. The extraction process was repeated three times using 250 mL of ethanol per plant material. All three extracts were combined, the mixture was fine filtered and concentrated in vacuo at 40-50°C to give a valerian alcohol extract of 0.01% to 30% total valerenic acid (LN16017) as a thick paste (16 g).

Embodiment 2

[0082] The dried root (100 g) of the plant material Valeriana wallichii was pulverized into a coarse powder and extracted with water (300 mL) at 80-85°C for 2 hours. The extraction process was repeated four times using 250 mL of water each time, the extracts were combined, the combined aqueous extracts were fine-filtered, and the clarified extract was concentrated on a climbing film evaporator under reduced pressure at 50-60°C to obtain a dry powder Aqueous extract of Valeriana (Valeriana wallichii) (LN16018) (25 g).

Embodiment 3

[0084] Process for preparing an odor masking formulation

[0085] program:

[0086] 1) Transfer 30ml of water to a clean and dry open container with a stirrer.

[0087] 2) Add 1 g of xanthan gum to it under low agitation and allow the contents to mix well. Keep the gum phase soaked overnight at room temperature to fully hydrate the gum phase in water. The glue:solvent ratio can vary depending on the type of glue and its swelling index, so the volume of solvent used for soaking can vary from 1:1.5 to 1:60.

[0088] 3) Fully mix the contents of the gum phase (after soaking) to obtain a uniform gum phase, and add 1 g of LN 16017 while continuing to stir to obtain a uniformly distributed drug-gel solution.

[0089] 4) After uniform mixing, load the sample to 40-80° C. to dry to obtain a dry substance.

[0090] 5) Crush and sieve the contents through the desired sieve to obtain a uniform, free-flowing powder mixture of Formulation-1.

[0091] Various odor-masking formulations...

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Abstract

The invention discloses odor masking formulations for stench natural compounds, selected from the extracts, fraction and pure phytochemicals that are produced in combination with a natural or synthetic hydrocolloid polymer gum(s). The invention further discloses novel process of producing the odor and taste masking formulations. The invention also discloses taste masking formulations of valerian extracts with no characteristic stench odor & or negligible stench odor in combination with natural hydrocolloid gum such as guar gum, acacia or other polymers. The invention further discloses method of reducing insomnia, anxiety, Attention Deficit Disorder (ADD), Chronic Fatigue Syndrome (CFS) using odor masking formulation of the current invention. Importantly, the said odor masked formulation ofthe present disclosure helps in improving sleep cycle and helps in efficient functioning of brain.

Description

[0001] invention technical field [0002] The present invention relates to odor masking formulations for objectionable odor compounds. In particular, the present invention relates to odor-masking formulations for objectionable-smelling natural compounds comprising extracts, fractions and pure phytochemicals obtained from herbs, and at least one hydrocolloid polymer of natural or synthetic origin and gum. The present invention also relates to a novel process for the production of an odor-masking formulation for offensive odor compounds comprising extracts, fractions and pure phytochemicals obtained from herbs and at least one of natural / synthetic origin Hydrocolloid polymers and gums. The present invention also relates to odor-masking formulations of Valeriana officinalis extracts, fractions or pure compounds in combination with at least one hydrocolloid polymer and gum of natural or synthetic origin. The present invention further relates to a method of treating insomnia, enha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/84A23L33/105A61K47/34
CPCA61K9/146A61K36/84A61P25/22A61P25/20A23L27/86A23L29/288A23V2002/00A23V2250/21A23V2300/10A23V2300/31A61K9/0056A61K47/38
Inventor 甘佳拉珠·顾坎拉珠罗摩拉珠·顾坎拉珠基索巴布·戈瓦达文卡塔克里史纳拉朱·阿尤里纳根德拉巴布·乌蒂基兰·布帕蒂拉朱韦恩凯特肯纳卡莱恩拉珠·顾坎拉珠帖木尔图卢·戈拉柯蒂
Owner LAILA NUTRACEUTICALS
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