Bone repair film and preparation method thereof

A bone repair and nanofiber membrane technology, applied in the field of bone repair membrane and its preparation, can solve the problems of performance damage, insufficient mechanical properties of electrospun membranes, lack of regeneration of natural periosteum, etc., to achieve enhanced mechanical properties and facilitate oriented growth , The effect of simplifying the surgical process

Inactive Publication Date: 2019-06-14
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the insufficient mechanical properties of the pure electrospun membrane, it can only be applied to the regeneration of soft tissue in non-load-bearing parts and the treatment of some small-sized bone defects.
In addition, the repair membranes des

Method used

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  • Bone repair film and preparation method thereof
  • Bone repair film and preparation method thereof
  • Bone repair film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Such as figure 1 As shown, this embodiment provides a bone repair membrane, which has a three-layer membrane structure, including an active layer 1 with osteoinductive properties, a barrier layer 2 that prevents soft tissue from growing in and enhances the overall mechanical properties of the membrane, and utilizes the soft tissue that grows in. A fixing layer 3 that fixes the whole membrane; the active layer 1 is in contact with the bone defect, the fixing layer 3 is in contact with soft tissue, and the barrier layer 2 is located between the active layer 1 and the fixing layer 3 . The active layer 1 and the fixed layer 3 are electrospun fiber membranes, the barrier layer 2 is a casting film, the electrospun fibers in the fixed layer 3 are aligned, and the active layer 1 contains active ingredient.

[0058] After implantation, the active layer 1 in contact with the bone defect can recruit bone-like cells and regenerate the natural periosteal cambium while accelerating ...

Embodiment 2

[0073] Such asfigure 1 As shown, this embodiment provides a bone repair membrane, which has a three-layer membrane structure, including an active layer 1 with osteoinductive properties, a barrier layer 2 that prevents soft tissue from growing in and enhances the overall mechanical properties of the membrane, and utilizes the soft tissue that grows in. A fixing layer 3 that fixes the whole membrane; the active layer 1 is in contact with the bone defect, the fixing layer 3 is in contact with soft tissue, and the barrier layer 2 is located between the active layer 1 and the fixing layer 3 . The active layer 1 and the fixed layer 3 are electrospun fiber membranes, the barrier layer 2 is a casting film, the electrospun fibers in the fixed layer 3 are aligned, and the active layer 1 contains active ingredient.

[0074] After implantation, the active layer 1 in contact with the bone defect can recruit bone-like cells and regenerate the natural periosteal cambium while accelerating bo...

Embodiment 3

[0089] Such as figure 1 As shown, this embodiment provides a bone repair membrane, which has a three-layer membrane structure, including an active layer 1 with osteoinductive properties, a barrier layer 2 that prevents soft tissue from growing in and enhances the overall mechanical properties of the membrane, and utilizes the soft tissue that grows in. A fixing layer 3 that fixes the whole membrane; the active layer 1 is in contact with the bone defect, the fixing layer 3 is in contact with soft tissue, and the barrier layer 2 is located between the active layer 1 and the fixing layer 3 . The active layer 1 and the fixed layer 3 are electrospun fiber membranes, the barrier layer 2 is a casting film, the electrospun fibers in the fixed layer 3 are aligned, and the active layer 1 contains active ingredient.

[0090] After implantation, the active layer 1 in contact with the bone defect can recruit bone-like cells and regenerate the natural periosteal cambium while accelerating ...

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Abstract

The invention provides a bone repair film and a preparation method thereof. The bone repair film is characterized by comprising an active layer, a barrier layer and a fixed layer. The barrier layer islocated between the active layer and the fixed layer, and the active layer and the fixed layer are electrospun fiber films. The barrier layer is a cast film, the electrospun fibers in the fixed layerare aligned in fiber orientation, and the active layer contains an active ingredient. The three-layer film structure is compounded by the electrospinning technology combined with the solution castingtechnology with the aid of vacuum filtration. The bone repair film has excellent performances for simultaneously regenerating natural bone tissues and periosteal tissues. The fixed layer of the bonerepair film has the special function of fixing the whole film to avoid the use of an external fixation device and simplify the surgical procedure. At the same time, the microstructure of the fixed layer orientation is favorable for the orientation growth of the soft tissues and has the function of regenerating the natural periosteal orientation fiber layer.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a bone repair membrane and a preparation method thereof. Background technique [0002] The periosteum is composed of microvascularized connective tissue that covers cortical bone surfaces except joints, and its thickness is age- and species-dependent (eg, ~40 μm in mouse tibia, ~100 μm in human tibia, ~200 μm in porcine mandible) . Traditionally, the periosteum is often divided into a superficial fibrous layer and a deep cambium, and there is no clear boundary between the two layers. The fibrous layer is thicker and consists of fibroblasts, a vascular network, and oriented (along the direction of bone growth) collagen fibers, and the thinner cambium is directly attached to the surface of the cortical bone and contains a variety of osteoid cells. Because of its association with blood vessels, the periosteum can be considered the "umbilical cord" of the bone (maint...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/56A61L27/50A61L27/12A61L27/10A61L27/02A61L27/54D04H1/728
Inventor 王富军刘来俊王璐李超婧张天添赵健安
Owner DONGHUA UNIV
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