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Chitin/graphene composite sponge, and preparation method and application thereof

A graphene composite and chitin technology, applied in applications, medical formulations, surgical adhesives, etc., can solve the problems of unfriendly environment, toxic reagents, and difficulty in large-scale production, so as to reduce the risk of secondary bleeding and excellent hemostasis Effect, preparation method Green effect

Inactive Publication Date: 2019-06-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the commonly used graphene preparation methods have problems such as lengthy reaction process, toxic reagents, unfriendly environment, high cost, and difficulty in large-scale production.

Method used

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  • Chitin/graphene composite sponge, and preparation method and application thereof
  • Chitin/graphene composite sponge, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The mixed powder of chitin and flake graphite with a mass ratio of 200:1 was dried in a vacuum oven at 105 °C for 4 h. Then the composite material was obtained by ball milling for 8 h in batch operation (10 min pause every 20 min, rotation speed 180 r / min).

[0030] The obtained composite material was added to 10% NaOH / 4% urea solvent at a mass ratio of 2:100, frozen at -40°C, then thawed while stirring at 23°C, freezing and thawing twice to make it evenly dispersed , after low-speed centrifugation (1800 rpm, time 20 min) to remove unexfoliated graphite flakes. Add 1 mL of cross-linking agent epichlorohydrin dropwise to every 10 g of the solution, and stir at 0 °C for 0.2 h to obtain a homogeneous solution. Continue to stand at 2 °C for 12 h to obtain chitin / graphene hydrogel.

[0031] The above hydrogel was dialyzed at 50 °C for 10 days, and then freeze-dried at -40 °C for 48 h to obtain a chitin / graphene composite sponge.

[0032] The coagulation index of the prepa...

Embodiment 2

[0034] The mixed powder of chitin and flake graphite with a mass ratio of 100:1 was dried in a vacuum oven at 100 °C for 6 h. Then, the composite material was obtained by ball milling for 4 h in batch operation (12 min pause every 25 min, speed 200 r / min).

[0035] The obtained composite material was added to 8% NaOH / 2% urea solvent at a mass ratio of 1:100, frozen at -30°C, then melted while stirring at 30°C, freeze-thawed 4 times to make it evenly dispersed , after low-speed centrifugation (2000 rpm, time 18 min) to remove unexfoliated graphite flakes. Add 0.5 mL of cross-linking agent epichlorohydrin dropwise to every 10 g of the solution, and stir at 4 °C for 1.2 h to obtain a homogeneous solution. Continue to stand at 4 °C for 8 h to obtain chitin / graphene hydrogel.

[0036] The above hydrogel was dialyzed at 40 °C for 14 days, and then freeze-dried at -80 °C for 52 h to obtain a chitin / graphene composite sponge.

[0037] The coagulation index of the prepared composite...

Embodiment 3

[0039] The mixed powder of chitin and flake graphite with a mass ratio of 20:1 was dried in a vacuum oven at 80 °C for 8 h. Then, the composite material was obtained by ball milling for 5 h in batch operation (stop for 15 min every 30 min, with a rotation speed of 210 r / min).

[0040] The obtained composite material was added to 15% NaOH / 8% urea solvent at a mass ratio of 6:100, frozen at -20 °C, then melted and stirred at 20 °C, and frozen and thawed 6 times to make it evenly dispersed , after low-speed centrifugation (3000 rpm, time 5 min) to remove unexfoliated graphite flakes. 2 mL of cross-linking agent epichlorohydrin was added dropwise to every 10 g of the solution, and stirred at 0 °C for 2 h to obtain a homogeneous solution. Continue to stand at 0°C for 24 h to obtain chitin / graphene hydrogel.

[0041] The above hydrogel was dialyzed at 60 °C for 7 days, and then freeze-dried at -50 °C for 72 h to obtain a chitin / graphene composite sponge.

[0042] The coagulation ...

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Abstract

The invention discloses a chitin / graphene composite hemostatic sponge and a preparation method thereof. The method comprises the following steps: mixing and ball-milling a certain amount of flake graphite and chitin, dissolving the obtained mixture in a NaOH / urea solvent, centrifuging the obtained solution, performing uniform dispersing, crosslinking the obtained material with an epichlorohydrin crosslinker, and standing, dialyzing and lyophilizing the crosslinked material to obtain the chitin / graphene composite sponge. The composite sponge has the advantages of excellent blood coagulation andhemostasis effects, good biodegradability and good cell compatibility. Compared with the prior art, the method for preparing the chitin / graphene composite material by using a ball milling-assisted stripping process has the advantages of simplicity, and easiness in implementation; the synergistic action of chitin and graphene makes the hemostatic sponge have an excellent hemostasis property; and the chitin is used as the raw material, so the prepared composite sponge is biodegradable, has good cell compatibility, and avoids the risk of secondary bleeding caused by the removal of the hemostaticmaterial after hemostasis treatment.

Description

technical field [0001] The invention belongs to the field of functional materials, and in particular relates to a chitin / graphene composite hemostatic sponge and a preparation method thereof, which can be used in related fields such as medical treatment and sanitation. Background technique [0002] At present, non-absorbable degradable hemostatic materials need to be removed by secondary surgery after use, and there are risks of blood scab rupture and pulling injury. Absorbable and degradable hemostatic materials (commonly used hyaluronic acid gel, collagen sponge, etc.) have good biodegradability, but the raw materials used have problems such as high cost and complicated purification process. Therefore, the use of low-cost, easy-to-prepare raw materials to develop degradable hemostatic materials has broad application prospects. [0003] Chitin is cheap, rich in sources and simple in extraction process. At the same time, chitin materials with excellent biocompatibility and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08K3/04C08J3/075C08J3/24C08J9/28A61L24/08A61L24/02A61L24/00
CPCC08J3/075C08J3/24C08L5/08C08J9/286C08J9/0061C08J2201/026C08J2201/048C08J2205/022C08J2207/10C08J3/203C08J2305/08A61L24/0078A61L24/0042A61L2300/108A61L2300/418A61L2400/04C08K3/042
Inventor 王小英李晓云黎珊珊
Owner SOUTH CHINA UNIV OF TECH
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