Drug-induced liver injury protecting and treating component and method

A technology for the treatment of drugs and acute liver injury, which is applied in the field of biomedicine and can solve problems such as inaccurate curative effects

Inactive Publication Date: 2019-06-21
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Drug-induced liver injury protecting and treating component and method
  • Drug-induced liver injury protecting and treating component and method
  • Drug-induced liver injury protecting and treating component and method

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[0020] The above content of the present invention will be further described in detail below through specific examples. However, it should not be understood that the scope of the above-mentioned subject matter of the present invention is limited only to the following examples. Without departing from the above-mentioned technical idea of ​​the present invention, various replacements or changes made according to ordinary technical knowledge and customary means in this field shall be included in the scope of the present invention.

[0021] In order to illustrate the present invention, we use the BABL / C mouse intraperitoneal injection of acetaminophen-induced acute liver injury model and the in vitro APAP-induced human liver cell L02 injury model to further study the method disclosed in the present invention. illustrate.

[0022] 1. Exploration of the pathological process of acetaminophen-induced liver injury in mice

[0023] 25 male BALB / C mice 6-8 weeks old, adaptively fed for ...

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Abstract

The invention discloses application of a chitosan oligosaccharide (COSM) with the molecular weight not higher than 3000 to preparing a drug-induced liver injury protecting and treating composition, particularly a composition for protecting and treating acetaminophen-induced liver injury. The invention also discloses a drug-induced liver injury protecting and treating method. The drug-induced liverinjury protecting and treating method comprises providing a liver injury patient with an effective quantity of the COSM. Experiments prove that the COSM can adjust acetaminophen-induced abnormity ofliver function biochemical indexes, significantly reduce abnormal rise of ALT (alanine transaminase) and AST (aspartate transaminase) in mice serum, improve acetaminophen-induced liver injury, improvethe content of a detoxicant of glutathione (GSH) in acetaminophen-induced liver injury-affected liver tissues, enhance the oxidation resistance of acetaminophen-induced oxidative injury-affected liver and reduce the content of malondialdehyde (MDA) of acetaminophen-induced liver oxidative injury. The COSM is expected to be developed and applied to treating liver injury caused by clinical treatment drugs and provide a better choice for patients.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the medical application of chitosan oligosaccharide with molecular weight ≤ 3000 in protecting and treating drug-induced liver injury. Background technique [0002] Drug-induced liver injury (DILI) refers to the direct toxicity of the drug itself or its metabolites to the liver after the human body is exposed to conventional or high doses of drugs, or the human body is allergic to the drug or its metabolites or Liver injury due to metabolic idiosyncratic reactions. Acetaminophen (APAP) is an analgesic widely used clinically. At therapeutic doses (<4g / d), APAP can cause transient elevations in serum aminotransferases, especially in malnourished, hepatic insufficiency Severe liver damage, even acute liver failure, may occur in people who drink excessively, drink alcohol or take some CYP450-inducing drugs (Acuteliver failure, ALF). It is estimated that about 2,...

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Application Information

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IPC IPC(8): A61K31/722A61P1/16
CPCA61K31/722A61P1/16
Inventor 苏政权
Owner GUANGDONG PHARMA UNIV
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