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A multi-drug staged continuous controlled release drug delivery system and its preparation method

A drug delivery system and staged technology, applied in the field of multi-drug staged continuous controlled release drug delivery system and its preparation, can solve the problems of electrospinning technology, such as danger, complicated operation, and expensive processing equipment

Active Publication Date: 2022-04-29
西安博恩生物科技有限公司
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Problems solved by technology

This method can only realize the time-sharing release of the two drugs, and the processing equipment used in this method is expensive and the operation is complicated, and the electrospinning technology has certain risks.
The prepared drug-loaded scaffolds are only suitable for the repair of bone defects

Method used

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  • A multi-drug staged continuous controlled release drug delivery system and its preparation method
  • A multi-drug staged continuous controlled release drug delivery system and its preparation method

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Embodiment Construction

[0043] Such as figure 1 As shown, the multi-drug staged continuous controlled release drug delivery system in the present invention is spherical, and its matrix material is sodium alginate (SA) hydrogel doped with different drug-loaded microspheres, and the drug-loaded microspheres are released in the order of Distributed along the radial direction of the system. That is, the microspheres that release the drug first are distributed on the surface of the system (the outermost layer of the sphere), and the microspheres that release the drug last are distributed in the center of the system (the center of the sphere). Layered distribution from outside to inside.

[0044] The basic process of the drug delivery system preparation method is:

[0045] Polyethylene lactide-polyethylene glycol monomethyl ether (PLGA-mPEG) block copolymer is used as the drug-loading matrix, and different drugs are respectively encapsulated by solvent evaporation method to form different drug-loaded mic...

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Abstract

The present invention proposes a multi-drug staged continuous controlled-release drug delivery system and its preparation method. The system is spherical in shape and is block-copolymerized with sodium alginate hydrogel doped with polyethylene lactide-polyethylene glycol monomethyl ether The drug-loaded microspheres are used as the matrix material, and the sodium alginate solution mixed with different drug-loaded microspheres is printed sequentially from outside to inside in the radial direction according to the prescribed drug release order by using a multi-nozzle 3D printer. Under the action of the solution, it can be quickly cross-linked and set. By controlling the molar ratio of lactide to glycolide in the drug-loaded matrix PLGA-mPEG and the forming position of the sodium alginate hydrogel doped with different drug-loaded microspheres, the staged continuous controlled release of various drugs can be achieved .

Description

technical field [0001] The invention belongs to the technical field of drug controlled release, and in particular relates to a multi-drug staged continuous controlled release drug delivery system and a preparation method thereof. Background technique [0002] Loading drugs or cytokines into drug delivery systems and controlling their release has become an effective treatment for many diseases, especially promising in tissue regeneration engineering. The treatment of many diseases requires long-term combined application of multiple drugs. For example, in bone tissue engineering technology, especially in the process of jaw bone reconstruction, different growth factors need to be administered at different stages of bone formation to exert synergistic effects between cytokines and promote bone formation. Proliferation, differentiation and expression of osteoblasts, thereby promoting bone reconstruction. Therefore, a single drug-loaded sustained-release system cannot meet the cu...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K47/36A61K9/16B33Y10/00B33Y80/00C08G63/08C08G65/331
Inventor 汪焰恩尹光德魏庆华郭莹张坤王艳梅
Owner 西安博恩生物科技有限公司
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