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Preparation method of self-supporting and self-repairing host-guest film

A self-healing, host-guest technology, applied in the field of self-supporting self-healing host-guest film preparation, can solve unreported problems, and achieve the effect of simple operation and short time.

Pending Publication Date: 2019-06-21
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, no related studies have been reported on self-supporting, self-healing thin films with host-guest interactions via layer-by-layer self-assembly techniques.

Method used

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  • Preparation method of self-supporting and self-repairing host-guest film
  • Preparation method of self-supporting and self-repairing host-guest film

Examples

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Effect test

preparation example Construction

[0022] A method for preparing a self-supporting self-repairing host-guest film, using layer-by-layer self-assembly technology to assemble β-cyclodextrin-modified silk fibroin and adamantane-modified hyaluronic acid onto the substrate surface, and using ethanol treatment to obtain self-supporting self- Repair host-guest film.

[0023] Including the following steps:

[0024] 1. Using EDC / NHS as a cross-linking agent, graft β-cyclodextrin on silk fibroin, and graft adamantane on hyaluronic acid to form β-cyclodextrin-silk fibroin and adamantane-hyaluronic acid solution;

[0025] 2. Using the brushing method in the layer-by-layer self-assembly technology, first brush a layer of β-cyclodextrin-silk fibroin on the surface of the glass sheet, dry at room temperature, and then brush a layer of adamantane-hyaluronic acid to dry, repeat 15-30 cycles of the above steps;

[0026] 3. After soaking in absolute ethanol for 24-48 hours, the film can be peeled off from the glass slide, and ...

Embodiment 1

[0029] 127mg EDC and 76mg NHS were formulated as EDC / NHS mixed solution.

[0030] Put 750mg of β-cyclodextrin and 320mg of silk fibroin together in the EDC / NHS mixed solution and activate at room temperature for 12 hours to obtain 8 mg / mL of β-cyclodextrin-silk fibroin solution.

[0031] 100 mg of adamantane and 160 mg of hyaluronic acid were placed in the EDC / NHS mixed solution and activated at room temperature for 12 hours to obtain a 4 mg / mL adamantane-hyaluronic acid solution.

[0032] Using the brushing method in the layer-by-layer self-assembly technology, first brush a layer of β-cyclodextrin-silk fibroin on the surface of the glass sheet with a brush, dry at room temperature, and then brush a layer of adamantane-hyaluronic acid to dry, repeat The above steps are 30 cycles.

[0033] Soak the prepared film in absolute ethanol for 24 hours, the film can be peeled off from the glass slide, and can be attached again after wetting other substrates.

Embodiment 2

[0035] 190mg EDC and 114mg NHS were formulated as EDC / NHS mixed solution.

[0036] 1477 mg β-cyclodextrin and 340 mg silk fibroin were placed in the EDC / NHS mixed solution and activated at room temperature for 16 hours to obtain 8.5 mg / mL β-cyclodextrin-silk fibroin solution.

[0037] 150 mg of adamantane and 200 mg of hyaluronic acid were placed in the EDC / NHS mixed solution and activated at room temperature for 16 hours to obtain a 5 mg / mL adamantane-hyaluronic acid solution.

[0038] Using the brushing method in the layer-by-layer self-assembly technology, first brush a layer of β-cyclodextrin-silk fibroin on the surface of the glass sheet with a brush, dry at room temperature, and then brush a layer of adamantane-hyaluronic acid to dry, repeat The above steps are 25 cycles.

[0039] Soak the prepared film in absolute ethanol for 32 hours, the film can be peeled off from the glass slide, and can be attached again after wetting other substrates.

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Abstract

The invention discloses a preparation method of a self-supporting and self-repairing host-guest film. Beta-cyclodextrin modified silk fibroin and adamantane modified hyaluronic acid are assembled on the surface of a substrate with a layer-by-layer self-assembly technology, and the self-supporting and self-repairing host-guest film can be obtained through ethanol treatment. The provided preparationmethod of the self-supporting and self-repairing host-guest film is simple, effective and simple to operate and requires shorter time, the self-supporting film has transferable morphology features, limitation in the aspect of substrates is overcome, and more actual application of the films can be met.

Description

technical field [0001] The invention relates to the field of preparation of self-supporting and self-repairing host-guest films, in particular to a preparation method of self-supporting and self-repairing host-guest films. Background technique [0002] Because the traditional film material is a two-dimensional ductile material, it needs a substrate as a support, and the commonly used substrate materials include single crystal silicon chips, mica chips, glass chips, etc. Although these materials are relatively stable, they have poor vertical permeability. , and the surface is not easy to modify other groups, so the development of thin film materials is largely limited. [0003] During the use of materials, local damage and microcracks will inevitably occur, which will affect the normal use of materials and shorten the service life; self-repair is an important issue. The core of self-repair is energy supply and material supply, imitating biological The principle of damage hea...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08L89/00C08L5/08
Inventor 宣红云杨宇民凌钰
Owner NANTONG UNIVERSITY
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