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Method for optimizing coating process of sugar-coated tablets

A program optimization and sugar-coated tablet technology, which is applied in sugar-coated pills, pharmaceutical formulations, drug delivery, etc., can solve the problems of long time-consuming sugar-coated tablet coating technology and great influence on semi-finished products, and achieve stable properties, reduce dependence, Optimizing the effect of traits

Inactive Publication Date: 2019-07-02
青岛冠龙生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The coating technology of sugar-coated tablets is time-consuming, and the production process largely relies on the experience and skills of employees. In terms of operation details, it depends on the person and location. The change of personnel has a greater impact on the semi-finished product coated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preheating:

[0022] Turn on the external heating of the coating pan to make the tablet bed temperature 30°C~40°C.

[0023] (2), package isolation layer:

[0024] Add 3% gelatin syrup once according to 25ml / kg of the plain tablet, it is advisable to make the surface of the tablet core fully wet and evenly distributed. Immediately sprinkle a small amount of talcum powder to make the talcum powder evenly adhere to the surface of the tablet core, blow hot air to heat to evaporate the water, and dry one side, then add gelatin paste and talcum powder, and wrap 4 layers until the tablet core is completely covered without exposure.

[0025] (3), powder coating layer:

[0026] The tablet core covered with the isolation layer continues to rotate in the pot, stop the blowing, add 70% simple syrup according to 25ml / kg of the plain tablet, and stir with the help of hands to make the tablet surface evenly moist, and then sprinkle an appropriate amount of talcum powder to make ...

Embodiment 2

[0032] (1) Preheating:

[0033] Turn on the external heating of the coating pan to make the tablet bed temperature 30°C~40°C.

[0034] (2), package isolation layer:

[0035] Add 3% gelatin syrup once according to 25ml / kg of the plain tablet, it is advisable to make the surface of the tablet core fully wet and evenly distributed. Immediately sprinkle a small amount of talcum powder to make the talcum powder evenly adhere to the surface of the tablet core, blow hot air to heat to evaporate the water and dry one side, then add gelatin paste and talcum powder, wrap 3 layers until the tablet core is completely covered without exposure.

[0036] (3), powder coating layer:

[0037] The tablet core covered with the isolation layer continues to rotate in the pot, stop the blowing, add 70% simple syrup according to 25ml / kg of the plain tablet, and stir with hands to make the tablet surface evenly moist, and then sprinkle an appropriate amount of talcum powder to make it evenly adsorbe...

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Abstract

The invention discloses a method for optimizing coating process of sugar-coated tablets. A technical scheme of the method for optimizing the coating process of the sugar-coated tablets comprises the steps of choosing reasonable coating temperature, choosing reasonable syrup addition amount during the coating process, and choosing reasonable addition times so as to improve properties of coated semi-finished products; and thus, quality standards of the coated semi-finished products meet all targets stipulated in the National Drug Standard. Moreover, the coated semi-finished products prepared bythe method have the advantages of being stable in properties, beautiful in appearance and so on.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, a method for improving the properties of coated semi-finished products by selecting a reasonable coating temperature, the amount of syrup added during coating and the number of additions. Background technique [0002] Sugar-coating can make the tablet beautiful, and can also cover the bad smell of traditional Chinese medicine, so that patients are willing to take it. [0003] The coating technology of sugar-coated tablets is time-consuming, and the production process largely depends on the experience and skills of employees. In terms of operation details, it depends on the person and location, and the change of personnel has a greater impact on the coating semi-finished product. Contents of the invention [0004] The invention provides reasonable coating temperature, adding amount and adding times of syrup during coating to improve the property of coating semi-finished product. Under...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K47/26
CPCA61K9/2826A61K9/2893
Inventor 刘乃山黄晓燕
Owner 青岛冠龙生物制药有限公司
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