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A preparation method of cyclohexanedicarboxylic acid derivative modified electrode for electrochemical recognition of tryptophan enantiomer

A technology for enantiomers of cyclohexanedicarboxylic acid and tryptophan, which is applied in the fields of electroanalytical chemistry and biology, and achieves the effect of simple, easy, and efficient identification.

Active Publication Date: 2021-03-16
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the published literature so far, there are few reports on the use of such cyclohexanedicarboxylic acid derivatives to modify electrodes for electrochemical chiral recognition.

Method used

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  • A preparation method of cyclohexanedicarboxylic acid derivative modified electrode for electrochemical recognition of tryptophan enantiomer
  • A preparation method of cyclohexanedicarboxylic acid derivative modified electrode for electrochemical recognition of tryptophan enantiomer
  • A preparation method of cyclohexanedicarboxylic acid derivative modified electrode for electrochemical recognition of tryptophan enantiomer

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Embodiment 1

[0027] The preparation of cyclohexanedicarboxylic acid derivative modified electrode for electrochemical recognition of tryptophan enantiomers includes the following steps:

[0028] (1) Dissolve 0.20g of cyclohexanedicarboxylic acid and 0.43g of dodecylamine in 20mL of tetrahydrofuran, then add 0.50g of dicyclohexylcarbodiimide, stir and react for 12 hours, remove the solvent by rotary evaporation, and use 50mL of acetic acid After the product was washed with ethyl ester, it was vacuum-dried to obtain a cyclohexanedicarboxylic acid derivative.

[0029] (2) Ultrasonically dissolve cyclohexanedicarboxylic acid derivatives in absolute ethanol to prepare a 1 mg / mL solution of cyclohexanedicarboxylic acid derivatives, and take 5 μL of cyclohexanedicarboxylic acid derivative solution and drop-coat it on the glassy carbon electrode The surface was dried at room temperature to obtain a cyclohexanedicarboxylic acid derivative-modified electrode.

[0030] (3) A three-electrode system w...

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Abstract

The invention relates to a preparation method of a cyclohexanedicarboxylic acid derivative modified electrode used for electrochemically recognizing a tryptophan enantiomer. The method comprises the steps that a cyclohexanedicarboxylic acid derivative is prepared; the cyclohexanedicarboxylic acid derivative modified electrode is prepared; and the tryptophan enantiomer is electrochemically recognized. According to the invention, the preparation method of the cyclohexanedicarboxylic acid derivative modified electrode is simple and easy; the preparation process is environmentally friendly and non-polluting; and the modified electrode can efficiently recognize the tryptophan enantiomer.

Description

technical field [0001] The invention relates to a preparation method of a cyclohexanedicarboxylic acid derivative modified electrode for electrochemically recognizing tryptophan enantiomers, and belongs to the fields of electroanalytical chemistry and biotechnology. [0002] technical background [0003] Chirality is ubiquitous in nature, and most organisms only have a single chiral configuration. The molecular structures of enantiomers in different configurations are mirror images of each other but cannot be superimposed. They have the same physical properties but exhibit completely different pharmacological activities, metabolic processes and toxicological effects in vivo. Amino acids are the basic units of biologically functional macromolecular proteins, and proteins are the main bearers of life activities. The chiral separation and analysis of amino acid enantiomers play a very important role in life sciences, medicinal chemistry, and human health. Among the reported chi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327G01N27/30
CPCG01N27/308G01N27/3277
Inventor 孔泳杨嘉佩吴大同
Owner CHANGZHOU UNIV