Ordered nanostructure array-based LSPR sensing device

A nanostructure and sensing device technology, applied in the field of optical sensors, to achieve the effect of qualitative detection and simple structure
CN109975249AInactive Publication Date: 2019-07-05SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2019-07-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an ordered nanostructure array-based LSPR (localized surface plasma resonance) sensing device. The ordered nanostructure array-based LSPR (localized surface plasma resonance)sensing device includes a light source unit, a sensing unit, a detection unit and a display unit; the sensing unit is arranged between the light source unit and the detection unit; the detection unitis electrically connected with the display unit; the light source unit is used for providing light signals; the sensing unit is a semi-closed cell culture dish of which the inner surface integrates anordered nanostructure array; the light signals emitted by the light source unit can pass through the sensing unit to reach the detection unit; the detection unit is used for converting the light signals into electric signals; and the display unit is used for outputting a detection result. According to the ordered nanostructure array-based LSPR (localized surface plasma resonance) sensing device disclosed by the invention, cell-substrate contact area signals are converted into LSPR spectral intensity signals in real time, so that the in-situ real-time monitoring of a cell adhesion and spreading whole process is realized; and the cell-substrate contact area signals are linearly related to the LSPR spectral intensity signals, so that the semi-quantitative monitoring of the cell adhesion andspreading whole process is realized.
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Description

technical field

[0001] The invention relates to the field of optical sensors, in particular to an LSPR sensing device based on an ordered nanostructure array. Background technique

[0002] The process of cell adhesion and spreading is the premise and basis of cell differentiation, proliferation and migration, and is an important criterion for evaluating the activity of cells on specific substrate materials or in specific biochemical environments. In the field of regenerative medicine, the cytocompatibility of implanted scaffolds is a key factor in evaluating their performance. The effectiveness of scaffold materials is usually evaluated by observing the adhesion rate and speed of cells on the surface of the scaffold. In the field of tumor research, the observation and monitoring of tumor cell adhesion behavior can lay a foundation for the study of tumor growth, invasion, regeneration and migration. In addition, the monitoring of cell adhesion and spreading process is also ...

Claims

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