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Ordered nanostructure array-based LSPR sensing device

A nanostructure and sensing device technology, applied in the field of optical sensors, to achieve the effect of qualitative detection and simple structure

Inactive Publication Date: 2019-07-05
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The use of LSPR sensors to detect cell adhesion and spreading processes has considerable significance and potential. However, there is still a lack of LSPR sensing devices for real-time and semi-quantitative monitoring of cell adhesion and spreading processes.

Method used

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  • Ordered nanostructure array-based LSPR sensing device
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  • Ordered nanostructure array-based LSPR sensing device

Examples

Experimental program
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Embodiment 1

[0025] This embodiment provides an LSPR sensing device based on an ordered nanostructure array, including a light source unit 1 , a sensing unit 2 , a detection unit 3 and a display unit 6 . The sensing unit 2 is arranged between the light source unit 1 and the detection unit 3 , and the detection unit 3 is electrically connected to the display unit 6 . The light source unit 1 is used to provide light signals. The sensing unit 2 is a semi-closed cell culture tank with an ordered nanostructure array integrated on the inner surface, which facilitates the adhesion and spreading of cells on the surface of the ordered nanostructure array in the culture tank. The light signal emitted by the light source unit 1 can pass through the sensing unit 2 to reach the detection unit 3, and the detection unit 3 is used for converting the light signal into an electrical signal. The display unit 6 is used to output detection results, and is generally a terminal with data processing and display ...

Embodiment 2

[0029] Such as figure 1 , figure 2 and image 3 As shown, this embodiment is similar to Embodiment 1, and further, the LSPR sensing device also includes a topography observation unit 4 and a topography recording unit 5, and the topography observation unit 4 is used in the observation sensing unit 2 The shape of the cell, the shape recording unit 5 is used to record the shape of the cell and transmit the result to the display unit 6. In this embodiment, the morphology observation unit 4 is a microscope with an optical magnification function, which can enlarge the topography image of the cell surface to be visible to the naked eye; The inductive coupling element for converting images into electrical signals converts the optical microscopic images into electrical signals in real time and transmits them to the display unit 6 . In addition, the light source unit 1 in this embodiment is a monochromatic light source, that is, it can be used directly without being processed by a b...

Embodiment 3

[0035]This embodiment is similar to embodiment 1 or 2, the main difference is that the light source unit 1 is a light emitting diode with a center wavelength of 700 nm. In addition, the ordered nanostructure array integrated on the inner surface of the sensing unit 2 is a gold nanotriangular array, and the sensing unit 2 , shape observation unit 4 and shape recording unit 5 are arranged on the same side of the light source unit 1 .

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Abstract

The invention relates to an ordered nanostructure array-based LSPR (localized surface plasma resonance) sensing device. The ordered nanostructure array-based LSPR (localized surface plasma resonance)sensing device includes a light source unit, a sensing unit, a detection unit and a display unit; the sensing unit is arranged between the light source unit and the detection unit; the detection unitis electrically connected with the display unit; the light source unit is used for providing light signals; the sensing unit is a semi-closed cell culture dish of which the inner surface integrates anordered nanostructure array; the light signals emitted by the light source unit can pass through the sensing unit to reach the detection unit; the detection unit is used for converting the light signals into electric signals; and the display unit is used for outputting a detection result. According to the ordered nanostructure array-based LSPR (localized surface plasma resonance) sensing device disclosed by the invention, cell-substrate contact area signals are converted into LSPR spectral intensity signals in real time, so that the in-situ real-time monitoring of a cell adhesion and spreading whole process is realized; and the cell-substrate contact area signals are linearly related to the LSPR spectral intensity signals, so that the semi-quantitative monitoring of the cell adhesion andspreading whole process is realized.

Description

technical field [0001] The invention relates to the field of optical sensors, in particular to an LSPR sensing device based on an ordered nanostructure array. Background technique [0002] The process of cell adhesion and spreading is the premise and basis of cell differentiation, proliferation and migration, and is an important criterion for evaluating the activity of cells on specific substrate materials or in specific biochemical environments. In the field of regenerative medicine, the cytocompatibility of implanted scaffolds is a key factor in evaluating their performance. The effectiveness of scaffold materials is usually evaluated by observing the adhesion rate and speed of cells on the surface of the scaffold. In the field of tumor research, the observation and monitoring of tumor cell adhesion behavior can lay a foundation for the study of tumor growth, invasion, regeneration and migration. In addition, the monitoring of cell adhesion and spreading process is also ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/552
CPCG01N21/554
Inventor 周建华谭雅尹张力
Owner SUN YAT SEN UNIV
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