Magnetic control graphene field effect transistor sensor, and manufacturing, measuring and detecting method thereof

Abstract

The invention proposes a magnetic control graphene field effect transistor sensor, and a manufacturing method, a measuring method and a detecting method thereof. The manufacturing method comprises thesteps of: transferring graphene onto a glass plate provided with indium tin oxide electrodes as a channel between the two electrodes; using a reaction chamber which is made of a glass material and adhered on the surface of a graphene film as a sample cell for accommodating an electrolyte; injecting PBASE dissolved in dimethyl sulfoxide DMSO into the sample cell, keeping the liquid for a set timeat room temperature, so that the PBASE completely reacts with the graphene, and removing the unreacted PBASE; introducing a probe aptamer into MGFET, and incubating the probe aptamer with the PBASE for a set time at room temperature, so that the probe aptamer fully reacts with the PBASE, and removing the unreacted probe aptamer; and adding a conjugate of magnetic nanoparticles and complementary DNA into the MGFET for a set time, so that the complementary DNA and the probe aptamer are completely combined. The resistance of the magnetic control graphene field effect transistor sensor is modulated by means of a magnetic field serving as a back gate, the impedance thereof changes with the intensity of the magnetic field, and the magnetic control graphene field effect transistor sensor exhibitsgood sensitivity.

Description

technical field The disclosure relates to the technical field of analytical chemistry, in particular to a magnetron graphene field-effect tube sensor and its fabrication, measurement and detection methods. Background technique Currently, there are a variety of biosensors for the detection of biomolecules, including fluorescent biosensors, electrochemical biosensors, and field-effect transistor biosensors. Among them, field-effect transistor biosensors have attracted extensive attention due to their high sensitivity and specificity. Field-effect transistors based on nanomaterials have been widely used in biosensors, including one-dimensional silicon nanowires, carbon nanotubes, and two-dimensional graphene. Graphene is a two-dimensional material with a single-layer sheet structure composed of carbon atoms. Due to its high specific surface area, high electrical conductivity, and excellent electron mobility at room temperature, these unique properties of graphene can be used...

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Problems solved by technology

However, when the electric field is enhanced, it may damage biological samples, and the sensitivity of biomolecular detection needs to be further improved

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