Platinum-dysprosium hetero-metal compound with high anti-tumor selectivity and production method thereof
An anti-tumor and selective technology, applied in the field of anti-tumor drugs, to achieve the effect of strong anti-tumor activity
Active Publication Date: 2019-07-09
SHAOYANG UNIV
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Problems solved by technology
It has also been reported recently that some rare earth metal complexes have certain antitumor effects, but the combination of platinum complexes and dysprosium complexes into a compound for antitumor selectivity analysis has not been reported yet.
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Embodiment 1
[0018] Example 1: Weigh platinum dichloride (0.05 mmol, 13.3 mg), dysprosium nitrate pentahydrate (0.05 mmol, 21.6 mg) and tropolone (0.015 mmol, 18.3 mg) in a 10*200 mm In a self-made hard glass tube with a back cover, slowly add 50 μL of 25-28% ammonia solution, DMF (1.5 mL) and H 2 O (0.5 mL), shake well and seal. Put it in an oven at 80°C for three days. Slowly cool down to room temperature after taking it out. Washing with a solvent gave pale yellow flaky crystals. Vacuum drying gave 0.0332 g, the yield was 40%.
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The invention discloses a platinum-dysprosium hetero-metal compound with high anti-tumor selectivity and a production method thereof. A chemical formula of the platinum-dysprosium hetero-metal compound with the high anti-tumor selectivity is [NH4]2[Pt(NH3)3(H2O)][Dy(Tro)4]4.3H2O. (Tro is tropolone with a hydrogen ion removed). The production method of the platinum-dysprosium hetero-metal compoundwith the high anti-tumor selectivity comprises the steps of weighing platinum dichloride, dysprosium nitrate pentahydrate and tropolone, placing the platinum dichloride, the dysprosium nitrate pentahydrate and the tropolone in a hard glass tube with a sealed bottom, adding ammonium hydroxide and a DMF solvent, sealing the glass tube with the sealed bottom, carrying out reaction at 60-85 DEG C for2-3 days, and cooling a reaction product to obtain the compound. Study results show that the anti-tumor activity of the platinum-dysprosium hetero-metal compound has good selectivity of tumor cells, and an IC50 value of the platinum-dysprosium hetero-metal compound of normal liver cells HL-7702 is larger than 100 [mu]mol.mL<-1>, which shows that the platinum-dysprosium hetero-metal compound has low toxicity to normal human body cells.
Description
technical field [0001] The invention relates to antitumor drugs, in particular to a platinum-dysprosium heterometal compound with strong antitumor selectivity, and also to a preparation method of the metal compound. Background technique [0002] There are many types of anti-tumor drugs and they are developing rapidly. Researchers have been unremitting in the research of anti-tumor drugs and have made certain achievements. However, many drugs are not highly targeted, have large side effects, and have unsatisfactory antitumor activity. Therefore, it is the direction and research goal of researchers to explore new anti-tumor drugs with strong selectivity, which are only effective on tumor cells and have low toxicity to normal cells. [0003] At present, metal complexes have been widely used in the field of medicine, such as early-stage tumor detection test strips. In the field of new anti-tumor drug research, metal complexes have had a huge impact on the treatment of tumors. ...
Claims
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Login to View More IPC IPC(8): C07F5/00A61P35/00
CPCA61P35/00C07F5/003
Inventor 李小芳
Owner SHAOYANG UNIV