Composition with effect of improving acute gastric mucosal injury

A gastric mucosal injury and composition technology, which is applied in the field of compositions that can improve acute gastric mucosal injury, can solve the problems of inexplicable medicinal value of woody incense, complex components of woody extract, and unclear differences in drug effects, etc. problems, achieve the effect of preventing acute gastric mucosal injury, improving gastric mucosal injury, and good application prospects

Inactive Publication Date: 2019-07-23
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dong Shu. Content determination and pharmacokinetic study of the main components of Akiras sinica [D]. Beijing: Beijing University of Chemical Technology, 2012: 1-63. Through pharmacokinetic experiments in mice, comparison of Akiras argentina extract and single The absorption behavior (blood-drug concentration and bioavailability) in the body of the combination drug of the body shows the difference in the blood concentration and bioavailability of the monomer and the extract from one aspect, but the components in the extract of the woody fragrance are complex, only From the perspective of pharmacokinetics, the medicinal value of woody drugs cannot be explained, and the specific differences in drug effects are not clear

Method used

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  • Composition with effect of improving acute gastric mucosal injury
  • Composition with effect of improving acute gastric mucosal injury
  • Composition with effect of improving acute gastric mucosal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Composition of the present invention

[0026] Take 96mg of corylidene (CO) and 32mg of dehydrocorylidene (DE) and mix them uniformly to obtain a composition of CO:DE=3:1.

Embodiment 2

[0027] Embodiment 2 compositions of the present invention

[0028] Take 96 mg of corylidene (CO) and 24 mg of dehydrocorylidene (DE) and mix them uniformly to obtain a composition of CO:DE=3:0.75.

Embodiment 3

[0029] Embodiment 3 compositions of the present invention

[0030] Take 96mg of corylidene (CO) and 384mg of dehydrocorylidene (DE) and mix them uniformly to obtain a composition of CO:DE=3:12.

[0031] Prove the beneficial effect of the present invention below by concrete test example:

[0032] 1 Experimental materials

[0033] 1.1 Instrument

[0034] Air-cooled centrifuge (Select BioProducts, USA);

[0035] UPT-II-10T type ultrapure water device (Chengdu Ultrapure Technology Co., Ltd.);

[0036] Low temperature refrigerator (Haier);

[0037] FSH-2A adjustable high-speed homogenizer (Changzhou Guowang Instrument Manufacturing Co., Ltd.);

[0038] FA2004N electronic balance (Shanghai Precision Scientific Instrument Co., Ltd.).

[0039] 352 microplate reader (Labsystems Multiskan MS, Finland)

[0040] 1.2 Experimental animals

[0041] Kunming male mice, weighing 18-22g, did not use any drugs before the experiment, provided by Chengdu Dashuo Experimental Animal Co., Ltd....

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PUM

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Abstract

The invention provides a composition with the effect of improving acute gastric mucosal injury. The composition is composed of 3 parts by weight of costunolide and 0.7-12 parts of dehydrocostus lactone. The composition of the invention can improve gastric mucosal injury, prevent acute gastric mucosal injury, significantly reduce the level of TNF-alpha, NF-kappaB, NO, iNOS and MDA in gastric mucosal injury, significantly increase the level of SOD and PCNA, and promote the healing of mucosal ulcer. When the proportion of components of the compositions is 3:1, the levels of proinflammatory factors, NO, iNOS, oxidative stress factors and PCNA are significantly affected (p is less than 0.001). The composition has a good application prospect.

Description

technical field [0001] The invention specifically relates to a composition capable of improving acute gastric mucosal injury. Background technique [0002] Gastric mucosa damage is caused by chemical factors: smoking, drinking, strong tea, coffee, and drugs that irritate the gastric mucosa such as aspirin, indomethacin, etc. Physical factors: too cold, too hot, too rough food or overeating, etc. Gastric mucosal bleeding, congestion and erosion damage caused by bacteria or their toxin stimulation and other factors. No matter what kind of invasive factors, the gastric mucosal injury caused by it shows a programmed injury response: first, the superficial mucosal injury is caused by the shedding of the superficial epithelium; further development of the injury, the injury of microvascular endothelial cells will lead to mucosal ischemia, Oxygen, tissue necrosis, resulting in deep mucosal damage: erosion or ulceration. Acute gastric mucosal injury is most commonly caused by alcoh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P1/04
CPCA61K31/365A61P1/04A61K2300/00
Inventor 胡慧玲谢余李奇娟刘芳刘巧
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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