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A silk fibroin hydrogel for the treatment of intrauterine adhesions

A silk fibroin and hydrogel technology, which is applied in the field of hydrogel for intrauterine adhesion treatment, can solve the problems of lack of intrauterine administration preparations, etc.

Active Publication Date: 2021-06-08
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is still a lack of intrauterine drug preparations that can meet the above requirements at the same time

Method used

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  • A silk fibroin hydrogel for the treatment of intrauterine adhesions
  • A silk fibroin hydrogel for the treatment of intrauterine adhesions
  • A silk fibroin hydrogel for the treatment of intrauterine adhesions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of the silk fibroin hydrogel of embodiment 1 intrauterine adhesion treatment

[0028] Preparation method: Measure the components of the hydrogel according to the mass ratio in Table 1, and prepare the experimental group and the control group of the silk fibroin hydrogel according to the following scheme:

[0029] (1) Divide 100g of distilled water into two equal parts;

[0030] (2) Add silk fibroin to half the amount of distilled water, dissolve and mix well, then add indocyanine green, mix well;

[0031] (3) Add poloxamer to half the amount of distilled water, dissolve and mix well, add cyclic dipeptide, and mix well;

[0032] (4) Add the solution of (2) into the solution of (3), mix well, add liquid fluorocarbon, mix well, and form a uniform hydrogel.

[0033] Table 1 Composition of the silk fibroin hydrogel experimental group and control group for the treatment of intrauterine adhesions

[0034]

[0035]

[0036] Note: " / ": means that the com...

Embodiment 2

[0037] In vivo application evaluation of silk fibroin hydrogel for the treatment of intrauterine adhesions in Example 2

[0038] (1) Rabbit intrauterine adhesion animal model

[0039] Animal preparation: healthy adult female non-pregnant ordinary grade New Zealand white rabbits, 3000g-4000g, free intake of water, adaptive feeding for 1 week.

[0040] Modeling operation: fasting for 12 hours before operation, New Zealand white rabbit (5 mg / kg) was injected into the ear vein with 20% urethane for anesthesia, the female rabbit was fixed on the experimental animal operating table in the supine position, and the skin knife was shaved Rabbit hair in the lower abdomen, disinfect the skin of the lower abdomen with alcohol, the incision is located at the upper 2 fingers of the pubic symphysis, take a longitudinal incision, incise the skin and muscles into the abdomen layer by layer, the incision is about 2cm long, check the bilateral uterus, and in the lower 1 / 2 of the uterus 0.5cm lo...

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Abstract

The invention provides a silk fibroin hydrogel for treating intrauterine adhesions. The main components of the hydrogel include silk fibroin, poloxamer, cyclic dipeptide, liquid fluorocarbon, and indocyanine green, wherein indocyanine Indocyanine green has a photothermal effect, and liquid fluorocarbons can be quickly converted into gases under the action of heat energy. Therefore, after the silk fibroin hydrogel for the treatment of intrauterine adhesions is given by intrauterine in situ injection, combined with the application of 785nm near-infrared light for intrauterine irradiation, it can rapidly expand and form an elastic three-dimensional structure hydrogel full of pores. For the efficient treatment of intrauterine adhesions.

Description

technical field [0001] The invention relates to a hydrogel for the treatment of intrauterine adhesions, in particular to the composition, preparation and application of the silk fibroin hydrogel injected in situ in the intrauterine cavity. Background technique [0002] Intrauterine adhesions are a common disease worldwide and have become the second leading cause of secondary infertility in women. Intrauterine adhesion (IUA) refers to the destruction of the basal layer of the endometrium caused by infection or injury, resulting in the formation of adhesions or fibrous scars in the uterine cavity. It has been more than 120 years since intrauterine adhesions were first reported by Fritsch. In 1948, Asherman described 29 cases of IUA in miscarriage or curettage, and defined it as a case of "impaired amenorrhea", which attracted people's attention to the disease and called it Asherman's syndrome (Asherman's syndrome, AS syndrome, AS). Current studies have found that intrauteri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/04A61L31/16
CPCA61L31/047A61L31/14A61L31/145A61L31/16A61L2400/06C08L89/00
Inventor 赵应征鲁翠涛姚情徐荷林郑雅文兰清华
Owner WENZHOU MEDICAL UNIV