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Multifunctional surgical operation flushing solution and preparation method and application thereof

A technology of surgical operation and flushing solution, which is applied in the direction of surgical drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as inability to effectively protect other tissues and organs

Inactive Publication Date: 2019-08-02
波士顿生物服务实验室公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The flushing solution is only used for brain surgery, not only cannot effectively protect other tissues and organs, but also does not mention other effects

Method used

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  • Multifunctional surgical operation flushing solution and preparation method and application thereof
  • Multifunctional surgical operation flushing solution and preparation method and application thereof
  • Multifunctional surgical operation flushing solution and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, the multifunctional surgical operation flushing liquid containing high concentration magnesium

[0049] Step 1: Accurately weigh 7344mg of NaCl, add 100ml of sterile water for injection and stir to dissolve.

[0050] Step 2: Accurately weigh MgSO 4 ·7H 2 O 30810mg add sterile water for injection 100ml and stir to dissolve

[0051] The third step: the above NaCl solution and MgSO 4 After the solution is mixed, add sterile water for injection to 1000ml. Adjust the pH value to 6.5-7.5 with NaOH and HCl at 25°C. Use a 0.22 μm microporous membrane filter to remove pyrogens, light inspection, and set aside.

[0052] The composition of the surgical rinsing fluid of this embodiment is as follows:

[0053]

Embodiment 2

[0054] Embodiment two, the multifunctional surgical operation flushing fluid containing high concentration magnesium ion+gelatin protein

[0055] Step 1: Accurately weigh 7344mg of NaCl, add 100ml of sterile water for injection and stir to dissolve.

[0056] Step 2: Accurately weigh MgSO 4 ·7H 2 Add 100ml of sterile water for injection to 30810mg and stir to dissolve.

[0057] Step 3: Treatment of gelatin (the purpose is to remove endotoxin): take 100g of gelatin (molecular weight 1000-36000 Daltons), add sterile water for injection to 990ml, heat to 50-80°C and stir for 30 minutes to dissolve. Add 20wt% NaOH 20ml and stir for 120 minutes to destroy endotoxin (0.1-0.2M NaOH has the best effect of destroying endotoxin), then add 36% HCl 10ml and stir for 10 minutes to neutralize. Other methods can also be used to remove endotoxins, such as activated carbon, anion exchange resin, endotoxin removal membrane and other methods.

[0058] The fourth step: further processing of ge...

Embodiment 3

[0062] Embodiment three, the multifunctional surgical operation flushing fluid containing medium concentration magnesium ion

[0063] Step 1: Accurately weigh 7344mg of NaCl, 298mg of KCl, add 100ml of sterile water for injection and stir to dissolve.

[0064] Step 2: Accurately weigh CaCl 2 2H 2 Add 100ml of sterile water for injection to O 198mg and stir to dissolve; accurately weigh MgSO 4 ·7H 2 Add 100ml of sterile water for injection to O 1479mg and stir to dissolve; accurately weigh NaHCO 3 Add 1899mg of sterile water for injection 100ml and stir to dissolve; accurately weigh Na 2 HPO 4 ·7H 2 Add 100ml of sterile water for injection to 198mg and stir to dissolve; Accurately weigh 800mg of glucose and add 100ml of sterile water for injection to dissolve.

[0065] The third step: after mixing all the solutions obtained in the first step and the second step, add sterile water for injection to 1000ml. Adjust the pH value to 6.5-7.5 with NaOH and HCl at 25°C. Use a ...

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Abstract

The invention discloses a multifunctional surgical operation flushing solution and a preparation method and application thereof. The multifunctional surgical operation flushing solution comprises an anti-spasm functional component and NaCl (sodium chloride). The multifunctional surgical operation flushing solution has the advantages that the vision field of operation is cleaned, the higher concentration of magnesium ions and glutin or albumin is maintained at the local part of a wound, and the operation is convenient, timely and efficient; the tissue organs can be protected, the pain of the operation wound can be relieved, the spasm of muscles around the wound is relieved, and the spasm of tissue blood vessels around the wound is relieved; the magnesium ions and the glutin or albumin in the surgical operation flushing solution disclosed by the invention can generate the synergistic function, so as to realize the preventing and treatment function on the pain of incision, spasm of muscles, spasm of blood vessels, and injury of tissues.

Description

technical field [0001] The invention relates to the technical field of medical medicine, in particular to a multifunctional surgical flushing liquid and its preparation method and application. Background technique [0002] During surgery, it is necessary to remove tissue fragments (such as bone debris, necrotic tissue), exuded blood, etc. generated during the operation to keep the surgical field of view clear. Irrigation fluid is usually used to remove these tissue debris and blood etc. The commonly used flushing solution is mainly normal saline. [0003] Interstitial fluid is the external environment for the survival of tissue cells, which directly contacts tissue cells and provides them with nutrients. The composition of interstitial fluid is similar to that of blood plasma, in which sodium ions (Na + ), potassium ions (K + ), calcium ions (Ca 2+ ), magnesium ions (Mg 2+ ), chloride ion (Cl - ), bicarbonate (HCO 3 - ) and glucose concentration are basically the sa...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K33/14A61K45/06A61K38/38A61K38/39A61P41/00
CPCA61K33/06A61K33/14A61K45/06A61K38/38A61K38/39A61K2300/00
Inventor 王砚明
Owner 波士顿生物服务实验室公司
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