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Antidepressant drug formula and preparation method thereof

A drug and formulation technology, which is applied in the field of antidepressant drug formulation and its preparation, can solve problems such as low affinity, influence on popularization and use, and easy recurrence, and achieve good synergy, good social benefits and economic benefits

Inactive Publication Date: 2019-08-09
栾云鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

① Drugs, because of many side effects and high toxicity, have been eliminated
In order to reduce side effects and reduce toxicity, some non-tricyclic antidepressants appeared in the 1970s, such as maprotiline, etc., but the side effects have not been completely overcome
③ Drugs, whose pharmacological feature is to specifically block the reuptake of serotonin, have a very low affinity for other neurotransmitter receptors in the brain, and have less toxic side effects than tricyclic drugs, but still have certain side effects
In a word, existing medicines all have some disadvantages: large side effects, high incidence rate, single mechanism of action, high price, easy recurrence, etc., which have seriously affected their popularization and use.
Since the existing products cannot meet the clinical needs, the development of new, high-efficiency, broad-spectrum, and low-toxic antidepressants has become one of the research and development directions of pharmaceutical companies in various countries.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] This embodiment provides an injection of a pharmaceutical composition for treating depression. The operation is as follows: Weigh 500 mg of industrial hemp mosaic leaf extract, 500 mg of artemisinin and its series derivatives, artesunate, add 200 mL of water for injection, and take 8 % NaOH solution to adjust the pH value to dissolve it; add 3g sodium chloride, add 0.2% activated carbon, boil for 15 minutes, filter, add water for injection to the filtrate to 1000mL; filter the medicinal solution with a 0.22μm microporous membrane, fill 5 bottles, capped, and autoclaved at 110°C for 40 minutes.

Embodiment 2

[0021] The present embodiment provides a dripping pill of a pharmaceutical composition for the treatment of depression, the operation is as follows: weigh 50 g of industrial hemp mosaic leaf extract, 10 g of artemether, and take appropriate amounts of polyethylene glycol 4000 and polyethylene glycol 6000, After being heated and melted in a water bath of 80-85°C, add the two kinds of raw materials weighed, mix well, keep the temperature at 75°C, drop into liquid paraffin (0-5°C), and make 1000 pellets to obtain the present invention. drop pill dosage form.

[0022] The pharmaceutical composition for treating depression provided by the present invention fully utilizes the advantages of the two active ingredients, helps to promote the further development of the industrial hemp industry, and has good social and economic benefits.

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PUM

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Abstract

The invention discloses an antidepressant drug formula and a preparation method thereof. The antidepressant drug is a preparation prepared from an effective dose of industrial cannabis sativa flower-leaf extract, artemisinin and its serial derivatives, as well as excipients pharmaceutically acceptable by the cannabis sativa flower-leaf extract and the artemisinin. The combination of the cannabis sativa flower-leaf extract and the artemisinin in use has a profound synergistic effect, the safe dosage range of the drug composition is large, the treatment effect is good, depression can be effectively prevented and / or treated, and a new choice is provided for clinical treatment of the depression.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an antidepressant medicine formulation and a preparation method thereof. Background technique [0002] Depression has become a common and frequently-occurring disease in modern society, and its incidence is still increasing. Symptoms are characterized by depressed mood, decreased interest, slowed thinking, and reduced speech and movement. Severe depression is characterized by world-weariness or suicidal thoughts. The suffering caused by these diseases to patients and their families, as well as the loss to society, is unmatched by many other diseases. According to a report published by the World Health Organization (WHO), affective disorders have now become the fourth largest disease in the world, and the number of depression patients worldwide has reached 340 million. The current incidence of depression in China is about 4%. At least 26 million people in China suffer from d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K31/366A61K31/05A61K31/357A61P25/24
CPCA61K31/05A61K31/357A61K31/366A61K36/60A61P25/24A61K2300/00
Inventor 栾云鹏郑双庆李志朋李襄
Owner 栾云鹏