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Local acute bleeding-stopping absorbable material and preparation method thereof

An absorbent material and acute technology, applied in the field of biomedical composite materials, can solve the problems of weak antibacterial properties of oxidized regenerated cellulose, slow hemostasis, low tissue compatibility, etc., and achieve good market application prospects, easy absorption, and high degree of polymerization low effect

Active Publication Date: 2019-08-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a local acute hemostasis absorbable material and its preparation method, which solves the problems of weak antibacterial properties of oxidized regenerated cellulose, low tissue compatibility and slow hemostasis speed

Method used

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  • Local acute bleeding-stopping absorbable material and preparation method thereof
  • Local acute bleeding-stopping absorbable material and preparation method thereof
  • Local acute bleeding-stopping absorbable material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] (1) With Acetobacter xylinum as the strain, after static culture in liquid medium at constant temperature for 10 days, the bacterial cellulose membrane was taken out and placed in sodium hydroxide solution, treated at 80°C for 2 hours, taken out, rinsed with deionized water until Obtain bacterial cellulose film after neutralization; soak in hyaluronic acid solution for 6 hours to obtain bacterial cellulose film soaked in hyaluronic acid;

[0032] (2) Weigh 4 g of the purified bacterial cellulose membrane, shred it and disperse it in a high-speed homogenizer to become a bacterial cellulose suspension.

[0033] (3) The bacterial cellulose suspension obtained in step (2) (solid content is 1-10g / L) is oxidized at room temperature through TEMPO / NaBr / NaClO mixed oxidation system, TEMPO consumption is 0.1mmol / g, NaBr It is 1 mmol / g. A certain amount of 10% NaClO solution was added to start the reaction, and 0.5M NaOH solution was added dropwise to maintain the pH of the react...

Embodiment 2

[0036] (1) With Acetobacter xylinum as the strain, after static culture in liquid medium at constant temperature for 10 days, the bacterial cellulose membrane was taken out and placed in sodium hydroxide solution, treated at 80°C for 2 hours, taken out, rinsed with deionized water until Obtain bacterial cellulose film after neutralization; soak in hyaluronic acid solution for 6 hours to obtain bacterial cellulose film soaked in hyaluronic acid;

[0037] (2) Weigh 4 g of the purified bacterial cellulose membrane, shred it and disperse it in a high-speed homogenizer to become a bacterial cellulose suspension.

[0038] (3) The bacterial cellulose suspension obtained in step (2) (solid content is 1-10g / L) is oxidized at room temperature through TEMPO / NaBr / NaClO mixed oxidation system, TEMPO consumption is 0.1mmol / g, NaBr It is 1 mmol / g. A certain amount of 10% NaClO solution was added to start the reaction, and 0.5M NaOH solution was added dropwise to maintain the pH of the react...

Embodiment 3

[0042] (1) With Acetobacter xylinum as the strain, after static culture in liquid medium at constant temperature for 10 days, the bacterial cellulose membrane was taken out and placed in sodium hydroxide solution, treated at 80°C for 2 hours, taken out, rinsed with deionized water until Obtain bacterial cellulose film after neutralization; soak in hyaluronic acid solution for 6 hours to obtain bacterial cellulose film soaked in hyaluronic acid;

[0043] (2) Weigh 4 g of the purified bacterial cellulose membrane, shred it and disperse it in a high-speed homogenizer to become a bacterial cellulose suspension.

[0044] (3) The bacterial cellulose suspension obtained in step (2) (solid content is 1-10g / L) is oxidized at room temperature through TEMPO / NaBr / NaClO mixed oxidation system, TEMPO consumption is 0.1mmol / g, NaBr It is 1 mmol / g. A certain amount of 10% NaClO solution was added to start the reaction, and 0.5M NaOH solution was added dropwise to maintain the pH of the react...

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Abstract

The present invention relates to a local acute bleeding-stopping absorbable material and a preparation method thereof. Bacterial cellulose is used as a substrate for preparing oxidized regenerated cellulose, and then the oxidized regenerated cellulose is subjected to electrostatic adsorption self-assembly with chitosan or chitosan and collagen. At the same time, the local acute bleeding-stopping absorbable material has characteristics of acute bleeding-stopping, broad-spectrum micro-organism-preventing, healing and body absorption promoting. The preparation method is green and environmentallyfriendly, and uniform and highly efficiently in compounding, and the obtained compound material is high in safety and has good market application prospects.

Description

technical field [0001] The invention belongs to the technical field of biomedical composite materials, in particular to a local acute hemostasis absorbable material and a preparation method thereof. Background technique [0002] Absorbable hemostatic material is a kind of biomedical material that can stop bleeding quickly and can be absorbed by the human body within a certain period of time. Its biggest feature is that it is applied to local wounds in humans or animals that are difficult to suture to stop bleeding. While achieving rapid hemostasis, it can be degraded in the body without taking it out, so as to avoid secondary damage caused by removing the dressing after hemostasis is completed. At present, commonly used absorbable hemostatic materials include fibrin glue-based hemostatic materials, gelatin sponge-based hemostatic materials, oxidized cellulose-based hemostatic materials, and chitosan-based hemostatic materials. The hemostatic mechanisms and usage methods of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/04
CPCA61L24/043A61L24/0042A61L2400/04C08L1/04C08L5/08C08L89/00
Inventor 洪枫袁海彬陈琳
Owner DONGHUA UNIV
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