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Absorbable hemostasis composite material based on polyanionic cellulose, and preparation method of absorbable hemostasis composite material

A technology of polyanionic and composite materials, which is applied in the field of absorbable hemostatic composite materials and its preparation, can solve the problems of weak antibacterial performance, low biocompatibility, and single hemostatic mechanism

Inactive Publication Date: 2021-05-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide an absorbable hemostatic composite material based on polyanionic cellulose and its preparation method, so as to overcome the small specific surface area and single hemostatic mechanism of oxidized regenerated cellulose modified materials in the prior art , low hemostatic efficiency, weak antibacterial performance, and low biocompatibility

Method used

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  • Absorbable hemostasis composite material based on polyanionic cellulose, and preparation method of absorbable hemostasis composite material
  • Absorbable hemostasis composite material based on polyanionic cellulose, and preparation method of absorbable hemostasis composite material
  • Absorbable hemostasis composite material based on polyanionic cellulose, and preparation method of absorbable hemostasis composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) The plant-derived oxidized cellulose nanofiber suspension (model NFC1904H) purchased from the market (Zhongshan Nanofiber New Material Co., Ltd.), the oxidation system is TEMPO / NaClO / NaBr co-oxidation system, English is TEMPO-oxidizedCellulose Nano-fiber , referred to as TCNF) was diluted with deionized water to a solid content of 1% (w / v), and fully stirred to obtain a uniform suspension with a pH value of 6.

[0061] (2) Divide the suspension obtained in step (1) into molds, and pre-freeze in a refrigerator at -80 degrees Celsius for 12 hours, and put it into a freeze dryer for 48 hours after pre-freezing to obtain a plant-derived oxidized cellulose nanofiber hemostatic material (TCNF ).

Embodiment 2

[0063] (1) Dilute the plant source oxidized cellulose nanofiber suspension (model NFC1904H, oxidation system is TEMPO / NaClO / NaBr co-oxidation system) purchased by the market (Zhongshan Nafibril New Material Co., Ltd.) to solid content 1% (w / v), and fully stirred to obtain a uniform suspension with a pH value of 6.

[0064] (2) 1 g of chitosan (Chitosan, CS) with a molecular weight of 50,000 was weighed and fully dissolved in 100 mL of 0.1 M glacial acetic acid aqueous solution to form a chitosan dilute acid solution with a final concentration of 1%.

[0065] (3) get the suspension liquid that makes in 10mL step (1) and put into small beaker, take the step of 10mL again ( 2) The prepared dilute chitosan acid solution was slowly dropped dropwise into a beaker, stirred while adding dropwise, and reacted for 30 minutes.

[0066] (4) Adjust the pH value of the gel suspension obtained in step (3) to 6 and repeatedly centrifuge and rinse, and finally collect the gel precipitate acco...

Embodiment 3

[0069] (1) Dilute the plant source oxidized cellulose nanofiber suspension (model NFC1904H, oxidation system is TEMPO / NaClO / NaBr co-oxidation system) purchased by the market (Zhongshan Nafibril New Material Co., Ltd.) to solid content 1% (w / v), and fully stirred to obtain a uniform suspension with a pH value of 6.

[0070] (2) Put 10 mL of the suspension obtained in step (1) into a small beaker, and add 0.09 g of collagen according to the mass ratio of plant-derived oxidized cellulose nanofibers / collagen (Collagen, COL)=1 / 0.9 Put the powder into a small beaker, stir and absorb for 30 minutes to obtain a suspension of plant-derived oxidized cellulose nanofibers adsorbed with collagen. Collagen can come from aquatic animals, such as fish, or terrestrial animals, such as cows and pigs.

[0071] (3) Take 1 g of chitosan with a molecular weight of 50,000 and fully dissolve it in 100 mL of 0.1 M glacial acetic acid aqueous solution to form a final concentration of 1% chitosan dilut...

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Abstract

The invention relates to an absorbable hemostasis composite material based on polyanionic cellulose, and a preparation method of the absorbable hemostasis composite material. The absorbable hemostasis composite material is obtained in a way that a network structure is established by taking the polyanionic cellulose as a base material, and then, the network structure carries out electrostatic adsorption self-assembling with chitosan or chitosan derivatives or carries out electrostatic self-assembling with the chitosan or the chitosan derivatives to load protein polypeptide, or the absorbable hemostasis composite material is obtained in a way that the network structure is established by taking the polyanionic cellulose as the base material, chitosan microspheres or chitosan microspheres and the protein polypeptide are subjected to in situ pelletizing, and then, loading is carried out on the surface and the network of the cellulose. The absorbable hemostasis composite material has the characteristics of acute hemostasis, broad-spectrum bacteria resistance, healing acceleration and in vivo absorption.

Description

technical field [0001] The invention belongs to the field of biomedical composite materials and their preparation, in particular to an absorbable hemostatic composite material based on polyanionic cellulose and a preparation method thereof. Background technique [0002] Uncontrollable massive blood loss and bleeding are often encountered problems in surgical operations. In war, 50% of deaths are caused by massive bleeding from wounds, 80% of which are due to wounds located in places that cannot be pressed to stop bleeding. Therefore, realizing rapid hemostasis of bleeding wounds has become an urgent problem to be solved. Hemostatic materials mainly prevent blood flow by forming a barrier, and accelerating blood coagulation depends on the production of fibrin. Absorbable hemostatic materials refer to medical products that can be absorbed by the body. Generally, during surgery, traditional hemostatic techniques are ineffective. Such products can be used to achieve hemostatic...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/00A61L24/08
CPCA61L24/08A61L24/102A61L24/104A61L24/108A61L24/0015A61L2300/232A61L2300/404A61L2300/252A61L2300/418A61L2400/04A61L2400/12C08L5/08C08L1/04C08L1/286C08L89/00
Inventor 洪枫刘亮韦昭刘露陈琳
Owner DONGHUA UNIV
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