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Absorbable material for local acute hemostasis and preparation method thereof

An absorbent material and acute technology, applied in the field of biomedical composite materials, can solve the problems of low tissue compatibility, weak antibacterial performance of oxidized regenerated cellulose, slow hemostasis, etc., achieve low degree of polymerization, good biodegradable performance, Easy to absorb effect

Active Publication Date: 2022-07-08
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a local acute hemostasis absorbable material and its preparation method, which solves the problems of weak antibacterial properties of oxidized regenerated cellulose, low tissue compatibility and slow hemostasis speed

Method used

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  • Absorbable material for local acute hemostasis and preparation method thereof
  • Absorbable material for local acute hemostasis and preparation method thereof
  • Absorbable material for local acute hemostasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Using Acetobacter xylinum as the strain, after culturing at a constant temperature in the liquid medium for 10 days, take out the bacterial cellulose membrane and place it in sodium hydroxide solution, treat it at 80 °C for 2 hours, take it out, and rinse it with deionized water until After neutralization, bacterial cellulose membrane was obtained; soaked in hyaluronic acid solution for 6 hours to obtain bacterial cellulose membrane soaked in hyaluronic acid;

[0032] (2) Weigh 4 g of the purified bacterial cellulose membrane, cut it into pieces, and then disperse it in a high-speed homogenizer to obtain a bacterial cellulose suspension.

[0033] (3) the bacterial cellulose suspension (solid content is 1-10g / L) obtained in step (2) is oxidized at room temperature by TEMPO / NaBr / NaClO mixed oxidation system, the amount of TEMPO is 0.1mmol / g, NaBr is 1 mmol / g. A certain amount of 10% NaClO solution was added to start the reaction, and the pH of the reaction system was...

Embodiment 2

[0036] (1) Using Acetobacter xylinum as the strain, after culturing at a constant temperature in the liquid medium for 10 days, take out the bacterial cellulose membrane and place it in sodium hydroxide solution, treat it at 80 °C for 2 hours, take it out, and rinse it with deionized water until After neutralization, bacterial cellulose membrane was obtained; soaked in hyaluronic acid solution for 6 hours to obtain bacterial cellulose membrane soaked in hyaluronic acid;

[0037] (2) Weigh 4 g of the purified bacterial cellulose membrane, cut it into pieces, and then disperse it in a high-speed homogenizer to obtain a bacterial cellulose suspension.

[0038] (3) the bacterial cellulose suspension (solid content is 1-10g / L) obtained in step (2) is oxidized at room temperature by TEMPO / NaBr / NaClO mixed oxidation system, the amount of TEMPO is 0.1mmol / g, NaBr is 1 mmol / g. A certain amount of 10% NaClO solution was added to start the reaction, and the pH of the reaction system was...

Embodiment 3

[0042] (1) Using Acetobacter xylinum as the strain, after 10 days of static culture in liquid medium at constant temperature, take out the bacterial cellulose membrane and place it in sodium hydroxide solution, treat it at 80°C for 2 hours, take it out, and rinse with deionized water until After neutralization, bacterial cellulose membrane was obtained; soaked in hyaluronic acid solution for 6 hours to obtain bacterial cellulose membrane soaked in hyaluronic acid;

[0043] (2) Weigh 4 g of the purified bacterial cellulose membrane, cut it into pieces, and then disperse it in a high-speed homogenizer to obtain a bacterial cellulose suspension.

[0044] (3) the bacterial cellulose suspension (solid content is 1-10g / L) obtained in step (2) is oxidized at room temperature by TEMPO / NaBr / NaClO mixed oxidation system, the amount of TEMPO is 0.1mmol / g, NaBr is 1 mmol / g. A certain amount of 10% NaClO solution was added to start the reaction, and the pH of the reaction system was maint...

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Abstract

The invention relates to an absorbable material for local acute hemostasis and a preparation method thereof. The oxidized regenerated cellulose is prepared by using bacterial cellulose as a substrate, and then electrostatically adsorbed and self-assembled with chitosan or chitosan and collagen. The invention also has the characteristics of acute hemostasis, broad-spectrum antibacterial, healing promotion and in vivo absorption; the preparation method is green and environmentally friendly, the compounding is uniform and efficient, and the obtained composite material has high safety and good market application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical composite materials, in particular to an absorbable material for local acute hemostasis and a preparation method thereof. Background technique [0002] Absorbable hemostatic material is a biomedical material that can be used in the bleeding site of a wound, can quickly stop bleeding, and can be absorbed by the human body within a certain period of time. Its biggest feature is that it can be applied to local difficult-to-suture wounds in humans or animals to stop bleeding. While achieving rapid hemostasis, it can be degraded in the body without removing it, thereby avoiding the secondary injury of removing the dressing after the hemostasis is completed. Currently commonly used absorbable hemostatic materials include fibrin glue hemostatic materials, gelatin sponge hemostatic materials, oxidized cellulose hemostatic materials and chitosan hemostatic materials. The hemostatic mechanisms and usage...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/04
CPCA61L24/043A61L24/0042A61L2400/04C08L1/04C08L5/08C08L89/00
Inventor 洪枫袁海彬陈琳
Owner DONGHUA UNIV
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