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Nasal composition and application thereof

A composition and a technique for nasal use, which are applied in the directions of drug combinations, plant raw materials, and medical preparations containing active ingredients, etc., can solve the problems that drugs for rhinitis are difficult to reach above the nasal cavity, difficult to treat, and inaccurate in curative effect, etc. The method is simple and easy to implement, and the effect of improving nasal discomfort and improving medication compliance

Inactive Publication Date: 2019-08-23
嘉兴市爵拓科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many drugs for the treatment of rhinitis at present, the curative effect is not exact
At the same time, because the medicine for general treatment of rhinitis is difficult to reach the top of the nasal cavity, it brings many difficulties to the treatment.

Method used

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  • Nasal composition and application thereof
  • Nasal composition and application thereof
  • Nasal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4

[0095] The nasal cavity drops were prepared according to the composition and content shown in Table 2 by conventional methods, and the content in Table 2 represented wt%.

[0096] Ingredient composition and content of the nasal cavity drops in table 2, embodiment 1~4

[0097]

[0098]

experiment example 2

[0105] Evaluation of nasal drip:

[0106] The evaluation index of nasal drip is divided into four items: "bitterness", "sweetness", "stimulation" and "stimulation duration", and the evaluation indicators of each item are from weak to strong (stimulation duration is stimulation time From short to long) are divided into 0, 1, 2, 3, 4 and 5 points, subdivided into "no feeling to weak" is 0 to 1 point, "moderate to strong" is 2 to 3 points, "strong to strong" Violent" is 4 to 5 points.

[0107] Each nasal cavity drop in Examples 1 to 4 and Comparative Examples V5 to V8 is filled in the drop container, and after spraying into the noses of 20 volunteers for 10 seconds, the nasal drop sensation evaluation test for the above items is carried out. The test results are shown in Table 4 below, and the results in Table 4 represent the average value of each evaluation score.

[0108] Table 4. Statistics of nasal dripping evaluation

[0109] Example Bitterness Sweetness e...

Embodiment 9

[0112] This embodiment provides a kind of curcumin monophosphate monosodium salt, dissolve 1.0g curcumin monophosphate in 300mL methanol, add 0.13g sodium methoxide, stir and react at room temperature for 1h, then evaporate the solvent under reduced pressure, and the residue is Dissolve in water: acetonitrile (1:8), place to crystallize, and filter to obtain the crystalline curcumin monophosphate monosodium salt.

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Abstract

The invention discloses a nasal composition and application thereof, and belongs to the technical field of rhinitis treatment preparations. The nasal composition comprises active components and further comprises medicinal auxiliary materials. The active components include exosome-like vesicles and curcumin monophosphate derivative from achyranthes aspera and pharmaceutically-accepted salt thereof.The medicinal auxiliary materials include quick-release medicinal auxiliary materials and / or slow-release medicinal auxiliary materials and / or other medicinal auxiliary materials. By using the two active components in the nasal composition in cooperation, immune globulin IgE can be effectively restrained, and the nasal composition has a positive effect on nasal cavity discomfort, especially rhinitis and more especially nasal cavity allergic inflammation caused by Th2 type immune overreaction; by using the active components in cooperation, the irritation and drop-in discomfort of the composition can be reduced, and the medication compliance of a patient is improved.

Description

technical field [0001] The invention belongs to the technical field of rhinitis treatment preparations, and in particular relates to a nasal composition and its application. Background technique [0002] With the change of environmental pollution, the weather is often erratic, and the frequent occurrence of heavy fog, smog, or dry weather in the north will affect the normal function of the human respiratory tract. The nasal cavity is the portal of human breathing, and it is responsible for breathing and immune defense. Sexual Physiological Function. Various nasal inflammations can be caused by genetic variation, environmental pathogenic factors, abnormal clearance function or immune defense function, etc. Epidemiological surveys show that the incidence of rhinitis in my country is as high as 37%, of which allergic rhinitis is about 11.3%, and the number of patients is close to 150 million. It has become one of the persistent diseases affecting people's quality of life. Rhi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/21A61P11/02A61P37/08A61K31/661
CPCA61K31/661A61K36/21A61P11/02A61P37/08A61K2300/00
Inventor 邹德双孟祥龙刘慧芬
Owner 嘉兴市爵拓科技有限公司
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