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Preparation method of novel diterpene sugar ester compound and use thereof

A technology of ester compounds and diterpene sugars, which is applied in the field of preparation of banana fusarium wilt inhibitors, can solve the problem of not screening high-efficiency chemical drugs

Inactive Publication Date: 2019-09-03
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 2015, Yang Miao found in "Main Banana Diseases and Prevention Methods in Guangxi" that during the screening process of antibacterial agents, no highly effective chemical drugs were screened

Method used

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  • Preparation method of novel diterpene sugar ester compound and use thereof
  • Preparation method of novel diterpene sugar ester compound and use thereof
  • Preparation method of novel diterpene sugar ester compound and use thereof

Examples

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preparation example Construction

[0027] A kind of preparation method of new diterpene sugar ester compound, the steps are as follows:

[0028] S1. Fermenting and culturing Penicillium sp.H1 (Penicillium sp.H1), and obtaining the fermentation product of Penicillium sp.H1, which contains the compound of formula I;

[0029] S2. Separating and purifying diterpene sugar esters from the fermented product containing formula I.

[0030] The separation and purification process of step S2 is as follows:

[0031] (1) Concentrate the fermented product obtained in step S1 to obtain extract, and pass through silica gel column chromatography under reduced pressure, eluting with petroleum ether-ethyl acetate gradient, collect and concentrate the eluate, detect and combine by TLC to obtain 6 Fractions, and recorded as Fr.1, Fr.2, Fr.3, Fr.4, Fr.5, Fr.6;

[0032] The elution gradient of petroleum ether-ethyl acetate in step (1) is as follows, the volume fraction ratio is 10:1, 8:1, 6:1, 4:1, 2:1, 1:1, 1:2.

[0033] (2) Afte...

Embodiment 1

[0038] A new diterpene sugar ester compound, its general chemical formula is the compound shown below:

[0039]

[0040] A kind of preparation method of new diterpene sugar ester compound, the steps are as follows:

[0041] S1. Fermenting and culturing Penicillium sp.H1 (Penicillium sp.H1), and obtaining the fermentation product of Penicillium sp.H1, which contains the compound of formula I;

[0042] The strain Penicillium sp.H1 was inoculated in PDA medium, cultured in a 28°C incubator for 3 days, and the cultured strain was inoculated into a cone of sterilized 200mL rice culture solution (rice 80g, NaCl 6.6g, tap water 120mL). In the bottle (1000mL), the culture was static at 28°C for 30d, and the fermentation scale was 10L.

[0043] S2. Separating and purifying diterpene sugar esters from the fermented product containing formula I.

[0044] After the fermentation product of step S1 was concentrated, the extracted extract was subjected to vacuum silica gel column chroma...

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Abstract

The invention discloses a novel diterpene sugar ester compound having a chemical formula as a formula (I) in the specification. The invention adopts the preparation method of the above novel diterpenesugar ester compound and the use thereof, and the diterpene sugar ester compound has an inhibitory effect on the fusarium wilt of banana.

Description

technical field [0001] The invention relates to the technical field of preparation of inhibitors of Fusarium wilt of banana, in particular to a preparation method and application of a novel diterpene sugar ester compound. Background technique [0002] Banana is a tropical fruit that people generally like to eat, and it is also an important economic crop and food crop. Guangxi is the main producing area of ​​bananas in my country, and its planting area and output both rank second in the country. Banana Fusarium wilt, a devastating fungal soil-borne disease that destroys vascular bundles and causes plant death caused by infestation by Fusarium oxysporum f.sp.cubense, which has 4 physiological races , of which race 4 is the most harmful, infecting almost all types of banana varieties. The prevention and control of banana fusarium wilt has become an important issue that urgently needs to be solved in the banana industry in Guangxi. [0003] Among the methods of preventing and...

Claims

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Application Information

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IPC IPC(8): C07H13/04C07H1/00A01N45/02A01P3/00C12P19/02C12R1/80
CPCC07H13/04C07H1/00A01N45/02C12P19/02
Inventor 王聪高谕康雷福厚谭学才申利群杜方凯李小燕
Owner GUANGXI UNIV FOR NATITIES
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