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A method of forming a temporary obstruction of the urethra

A blocking and temporary technology, applied in the fields of medical science, surgery, ligation, etc., can solve the problem of time-consuming and laborious, and achieve the effect of convenient removal

Active Publication Date: 2020-09-01
长睿生物技术(成都)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After one operation, it is often necessary to locate and ultrasound the stones many times, which is time-consuming and laborious

Method used

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  • A method of forming a temporary obstruction of the urethra
  • A method of forming a temporary obstruction of the urethra
  • A method of forming a temporary obstruction of the urethra

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] This embodiment provides a temporary urethral obstruction precursor, the preparation method of which is as follows:

[0048] S1. Stir and mix the isinglass and hydrochloric acid solution evenly at 8° C. to prepare a isinglass solution with a isinglass content of 1 wt%.

[0049] S2. Maintain stirring at -1°C, slowly add NaOH solution dropwise to the isinglass solution, and adjust the pH value of the isinglass solution to 5.1.

[0050] S3. Continue stirring at 1° C., and slowly add a pH value stabilizer to the isinglass solution at a rate of 6 wt% per minute, and complete the addition in 20 minutes to obtain a temporary urethral obstruction precursor.

[0051] The specific ion / molecule pair contained in this pH stabilizer is Tris-H + , after the addition, Tris-H in the solution + The concentration is 5M. In order to precisely control the pH value of the solution, NaOH solution was further added dropwise to ensure that the pH range of the solution was 5.5±1.

Embodiment 2

[0053] This embodiment provides a temporary urethral obstruction precursor, the preparation method of which is as follows:

[0054] S1. Stir and mix chitosan, sodium alginate and ammonia solution evenly to form a solution with a chitosan content of 10 wt% and a sodium alginate content of 0.1 wt%.

[0055] S2. Maintain stirring at 4° C., slowly add citric acid solution dropwise to the above solution, and adjust the pH value of the solution to 8.0.

[0056] S3. Continue to stir at -2°C, and slowly add a pH value stabilizer to the above solution at a rate of 10 wt% per minute, and complete the addition in 5 minutes to obtain a temporary urethral obstruction precursor.

[0057] The specific ion / molecule pair contained in this pH stabilizer is NH 4 + -NH 3 and HPO 4 2- -H + - Triethylamine, after addition, NH in solution 4 + -NH 3 The concentration is 5M, HPO in solution 4 2- -H + - The concentration of triethylamine is 0.01M. The pH range of the solution was 6.8±1.

Embodiment 3

[0059] This embodiment provides a temporary urethral obstruction precursor, the preparation method of which is as follows:

[0060] S1. Stir and mix the hyaluronic acid, collagen, oxalic acid, and acetic acid solutions evenly, and prepare a solution with a hyaluronic acid content of 88wt% and a collagen content of 0.25wt%.

[0061] S2. Maintain stirring at 2° C., slowly add KOH solution dropwise to the above solution, and adjust the pH value of the solution to 6.8.

[0062] S3. Continue to stir at -2°C, and slowly add a pH value stabilizer to the above solution, the addition method is 8 wt% per minute, and the addition is completed in 30 minutes to obtain a temporary urethral obstruction precursor.

[0063] The specific ion / molecule pair contained in this pH stabilizer is Borax-Ac - and CO 3 2- - citric acid, after addition, borax-Ac in solution - The concentration is 0.02M, CO in the solution 3 2- - The concentration of citric acid is 0.02M and the pH range of the solut...

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Abstract

A method for forming a temporary urethral obstruction relates to the field of medical materials. Through dissolving under non-electric neutral conditions, biological materials can be dissolved more fully, and a stable and uniform biological material solution can be obtained. Then in a low temperature environment, the biological material solution is adjusted so that the molecules are electrically neutral. The low-temperature environment ensures that the biological material solution remains in a solution state during the process of returning to electrical neutrality, avoiding the precipitation of biological materials and destroying the stability of the solution. Finally, a pH value stabilizer is added to precisely control the pH range of the temporary obstruction precursor of the urethra to obtain the temporary obstruction precursor. The temporary obstruction precursor is in a free fluid state under low temperature conditions, and can be injected or introduced into the urethra in situ, and rapidly phase-transforms into a gel-state temporary obstruction in the urethra to achieve the purpose of blocking the urethra. At the same time, the temporary obstruction of the urethra can be quickly phase-transformed into a free fluid state through low-temperature treatment, and is easy to remove.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a method for forming a temporary obstruction of the urethra. Background technique [0002] Tubular structures, such as blood vessels or the urethra, may need to be temporarily blocked during practical applications. For example, in ultrasonic lithotripsy for urinary stones, the purpose is to ultrasound the site where the stones are located, so that the stones can be fragmented and smaller, and discharged along the urinary tract. However, in actual operation, the stone cannot be completely pulverized through one ultrasound. After the stone is only slightly reduced in size and loosened, it can leave the ultrasound site and move down or up. However, this partially fragmented stone is not enough to pass through the urethra, and will re-form blockage in other places in the urethra during the excretion process, and even go up to the kidney. This requires the operator to reposition and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B17/12A61B17/22
CPCA61B17/1204A61B17/12099A61B17/12181A61B17/22004
Inventor 王峰杜明春邓飞沈健
Owner 长睿生物技术(成都)有限公司
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