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Liquid cymene and preparation method and application thereof

A cymene, liquid technology, applied in the fields of skin care products and daily chemical products, can solve problems such as low solubility, skin irritation, and inability to exert efficacy

Active Publication Date: 2019-09-10
广州汇朗生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] O-cymene-5-ol currently on the market is mainly supplied in the form of colorless or white crystalline powder, however, O-cymene-5-ol has a rather low solubility in water and has a characteristic tendency to precipitate and crystallize , it is easy to precipitate when used in water-based products, and cannot exert its effect
The existing method of dissolving O-cymene-5-ol is usually to use a solubilizer with ethanol to solubilize O-cymene-5-ol, but if ethanol is used in skin care products, it will somewhat irritate the skin

Method used

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  • Liquid cymene and preparation method and application thereof
  • Liquid cymene and preparation method and application thereof
  • Liquid cymene and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The present embodiment provides a kind of liquid cymene, and the weight percent of each component is as follows:

[0037]

[0038] The preparation method of above-mentioned liquid cymene is as follows:

[0039] Add O-cymene-5-ol to the 1,2-pentanediol, heat to 78°C, stir, cool down to 45°C, then add PPG-26-butanol-26 and PEG-40 Hydrogenated castor oil, ie.

Embodiment 2

[0041] The present embodiment provides a kind of liquid cymene, and the weight percent of each component is as follows:

[0042]

[0043] The preparation method of above-mentioned liquid cymene is as follows:

[0044] Add O-cymene-5-ol to the 1,2-pentanediol, heat to 78°C, stir, cool down to 45°C, then add PPG-26-butanol-26 and PEG-40 Hydrogenated castor oil, ie.

Embodiment 3

[0056] Stability study

[0057] The stability of the liquid cymene prepared in Example 1-2 and Comparative Example 1-2 was investigated.

[0058] Since liquid cymene usually needs to be diluted when used, it is diluted to examine its stability. The method is: mix the liquid cymene prepared in Example 1 with water at a ratio of 1:9, divide the mixture into 3 equal parts, then place the first part at 48°C, and place the second part at Place it at -18°C, and place the third portion at 25°C. Similarly, dilute the liquid cymene prepared in Example 2, Comparative Example 1 and Comparative Example 2 according to the same method and ratio, and divide them into three grades points, respectively at 48 ℃, -18 ℃ and 25 ℃. Observe whether there is solid precipitation of liquid cymene after 24h, 72h, 7d, 14d, 30d, 45d, 60d, and 90d. The results are shown in Table 1-2.

[0059] Table 1

[0060]

[0061]

[0062] Table 2

[0063]

[0064]As can be seen from Table 1 and Table 2, ...

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Abstract

The invention relates to liquid cymene and a preparation method and application thereof. The liquid cymene is prepared by mixing 10-15% of O-cymene-5-alcohol, 10-50% of 1,2-pentanediol, 10-40% of PPG-26-butanol polyether-26, 15-40% of PEG-40 hydrogenated castor oil and 1-10% of water by weight percentage. In the liquid cymene, the content of the O-cymene-5-alcohol can reach 10-15%, and meanwhile,the liquid cymene has the advantages of being high in stability, low in irritation and excellent in antibacterial and acne-removing efficacy.

Description

technical field [0001] The invention relates to the fields of skin care products and daily chemical products, in particular to liquid cymene and its preparation method and application. Background technique [0002] O-cymene-5-ol, molecular formula C 10 h 14 O, has been proven to have excellent efficacy in various skin care products. It has high stability, extremely low odor, and strong antioxidant capacity. This kind of safety has been confirmed and obtained the safety evaluation of CIR in the United States. O-cymene-5-ol can be used as a bactericidal preservative in cosmetic formulations, against Propionibacterium acnes, low irritation, no allergic reaction to the skin, and can also be used as a deodorant, in cosmetics, medical pharmaceuticals and It is widely used in antibacterial and anti-mite products in the industrial field. [0003] O-cymene-5-ol currently on the market is mainly supplied in the form of colorless or white crystalline powder, however, O-cymene-5-ol ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/34A61K8/86A61K8/92A61K8/96A61K8/368A61Q17/00A61Q19/00A61P17/10A61P31/04A61P31/02A61P31/10
CPCA61K8/0204A61K8/347A61K8/345A61K8/86A61K8/922A61K8/965A61K8/368A61Q17/005A61Q19/00A61P17/10A61P31/04A61P31/02A61P31/10A61K2800/782A61K2800/5922Y02A50/30
Inventor 梁念山阮婷婷回毅廖慧舒刘亚娟林芸
Owner 广州汇朗生物科技有限公司
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