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Liquid cymene and its preparation method and application

A cymene, liquid technology, applied in the fields of daily chemical products and skin care products, can solve problems such as low solubility, inability to exert efficacy, and skin irritation.

Active Publication Date: 2022-07-05
广州汇朗生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] O-cymene-5-ol currently on the market is mainly supplied in the form of colorless or white crystalline powder, however, O-cymene-5-ol has a rather low solubility in water and has a characteristic tendency to precipitate and crystallize , it is easy to precipitate when used in water-based products, and cannot exert its effect
The existing method of dissolving O-cymene-5-ol is usually to use a solubilizer with ethanol to solubilize O-cymene-5-ol, but if ethanol is used in skin care products, it will somewhat irritate the skin

Method used

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  • Liquid cymene and its preparation method and application
  • Liquid cymene and its preparation method and application
  • Liquid cymene and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The present embodiment provides a kind of liquid cymene, and the weight percent of each component is as follows:

[0045] O-cymene-5-ol 10%;

[0046] 1,2-Pentanediol 40%;

[0047] PPG-26-butanol polyether-26 27%;

[0048] PEG-40 Hydrogenated Castor Oil 18%;

[0049] Water 5%.

[0050] The preparation method of above-mentioned liquid cymene is as follows:

[0051] Add O-cymene-5-ol to the 1,2-pentanediol, heat to 78°C, stir, cool down to 45°C, then add PPG-26-butanol polyether-26 and PEG-40 Hydrogenated castor oil, that is.

Embodiment 2

[0053] The present embodiment provides a kind of liquid cymene, and the weight percent of each component is as follows:

[0054] O-cymene-5-ol 15%;

[0055] 1,2-Pentanediol 20%;

[0056] PPG-26-butanol polyether-26 35%;

[0057] PEG-40 Hydrogenated Castor Oil 23%;

[0058] Water 7%.

[0059] The preparation method of above-mentioned liquid cymene is as follows:

[0060] Add O-cymene-5-ol to the 1,2-pentanediol, heat to 78°C, stir, cool down to 45°C, then add PPG-26-butanol polyether-26 and PEG-40 Hydrogenated castor oil, that is.

Embodiment 3

[0080] Stability investigation

[0081] The stability of the liquid cymene prepared in Example 1-2 and Comparative Example 1-2 was investigated.

[0082] Since liquid cymene usually needs to be diluted, it is diluted to investigate its stability. The method is as follows: the liquid cymene prepared in Example 1 is mixed with water in a ratio of 1:9, the mixture is divided into 3 equal parts, and then the first part is placed at 48° C. Placed at -18°C, and the third part was placed at 25°C. Similarly, the liquid cymene prepared in Example 2, Comparative Example 1 and Comparative Example 2 were diluted according to the same method and ratio, and divided into three classes. were separated and placed at 48°C, -18°C and 25°C, respectively. Observe whether the liquid cymene has solid precipitation after 24h, 72h, 7d, 14d, 30d, 45d, 60d, and 90d. The results are shown in Table 1-2.

[0083] Table 1

[0084]

[0085] Table 2

[0086]

[0087] It can be seen from Table 1 and...

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Abstract

The present invention relates to a liquid cymene and its preparation method and application. The liquid cymene is formed by mixing the components comprising the following percentages by weight: O-cymene-5-alcohol 10%-15%; 1,2-pentanediol 10%-50%; PPG-26- Buteth-26 10%-40%; PEG-40 Hydrogenated Castor Oil 15%-40%; Water 1%-10%. In the liquid cymene, the content of O-cymene-5-alcohol can be as high as 10%-15%, and meanwhile the stability is good, the irritation is low, and the antibacterial and acne-removing effect is excellent.

Description

technical field [0001] The invention relates to the fields of skin care products and daily chemical products, in particular to liquid cymene and a preparation method and application thereof. Background technique [0002] O-Cymen-5-ol, molecular formula C 10 H 14 O, has been proven to have excellent efficacy in various skin care products, with high stability, extremely low odor, and strong antioxidant capacity. This safety has been confirmed and obtained the safety evaluation of the US CIR. O-cymene-5-ol can be used as a bactericidal preservative in cosmetic formulations, against Propionibacterium acnes, with low irritation and no allergic reaction to the skin, and can also be used as a deodorant. It is widely used in antibacterial and anti-mite products in the industrial field. [0003] O-Cymen-5-ol currently on the market is mainly supplied in the form of colorless or white crystalline powder, however, the solubility of O-Cymen-5-ol in water is rather low, and it has a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/02A61K8/34A61K8/86A61K8/92A61K8/96A61K8/368A61Q17/00A61Q19/00A61P17/10A61P31/04A61P31/02A61P31/10
CPCA61K8/0204A61K8/347A61K8/345A61K8/86A61K8/922A61K8/965A61K8/368A61Q17/005A61Q19/00A61P17/10A61P31/04A61P31/02A61P31/10A61K2800/782A61K2800/5922Y02A50/30
Inventor 梁念山阮婷婷回毅廖慧舒刘亚娟林芸
Owner 广州汇朗生物科技有限公司
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