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Use of bile acid combined markers in the preparation of detection reagents or detection materials for predicting or diagnosing diabetes

A marker, bile acid technology, applied in the field of biomedicine, can solve problems such as elevated serum bile acid levels

Active Publication Date: 2021-09-28
SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES +1
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Problems solved by technology

[0004] In recent years, metabolomics technology has developed rapidly in the field of diabetes. Chromatography-mass spectrometry technology is the main research method of metabolomics. Bile acidomics technology is to use metabolomics technology to explore the role and influence of bile acids on the results. Marlene Wewalka The research of et al. showed that compared with the normal control population, the serum bile acid level of diabetic patients was significantly increased. However, there is no research report on the application of bile acid combined markers in the detection of new-onset diabetes

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  • Use of bile acid combined markers in the preparation of detection reagents or detection materials for predicting or diagnosing diabetes
  • Use of bile acid combined markers in the preparation of detection reagents or detection materials for predicting or diagnosing diabetes

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Embodiment Construction

[0018] Below in conjunction with embodiment, the present invention will be further described:

[0019] Definition of diabetes: fasting blood glucose (FBG) ≥ 126 mg / dL or 2-hour postprandial blood glucose (2-h BG) ≥ 200 mg / dL, or research subjects self-reported that they had been diagnosed with diabetes by a professional physician and were taking hypoglycemic drugs.

[0020] In this example, we start from the discovery population (n=122). We use Shimadzu nexera x2 ultra-high performance liquid chromatography, the mass spectrometer is Shimadzu triple quadrupole 8050, and the negative ion mode of electrospray ionization (ESI) source is used to analyze serum Different bile acids were tested, and after adjusting related confounding factors (including age, BMI, fasting blood sugar, smoking and drinking status, family history of diabetes, education level, physical activity, etc.), it was found that the 5 kinds of bile acids had a statistically significant relationship with the occurre...

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Abstract

The invention discloses the use of a bile acid combined marker in the preparation of a detection reagent or a detection object for predicting or diagnosing diabetes. The bile acid combined marker consists of glycocholic acid, sodium glycochenodeoxycholate, taurocholic acid, Composed of sodium taurochenodeoxycholate and sodium tauroursodeoxycholate, by detecting the concentration level of the above bile acid joint markers, the data calculated based on the above ROC curve is used to predict the risk of diabetes, with high detection sensitivity and low detection cost Low, good repeatability.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to the use of bile acid joint markers in the preparation of detection reagents or detection objects for predicting or diagnosing diabetes. Background technique [0002] Diabetes mellitus (DM) is one of the most common chronic diseases, with long-term chronic hyperglycemia as its main clinical feature. public health issues. According to the report of the World Health Organization (WHO), in 2014, there were 422 million adults suffering from diabetes in the world, and the global prevalence rate of diabetes was 8.5%. A national survey conducted by Ruijin Hospital affiliated to the hospital in 2010 showed that the prevalence of adult diabetes in my country was 11.6%, and as many as 110 million adults suffered from diabetes. important reason for the high mortality rate of patients. [0003] At present, the diagnosis of diabetes is mainly based on the level of plasma glucose. However,...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/045
Inventor 宁光王卫庆毕宇芳许国旺陆洁莉李勉赵欣捷王霜原徐瑜徐敏杜瑞王晓琳李琦
Owner SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES
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