Preparation method of D/L-dibenzoyl tartaric acid

Abstract

The invention discloses a preparation method of D / L-dibenzoyl tartaric acid. The preparation method comprises following steps: step one, adding 100 parts of D / L-tartaric acid and a proper amount of a solvent into a reactor, then adding 2 to 10 parts of a catalyst and 80 to 110 parts of benzoyl chloride under stirring, carrying out reactions for 20 to 40 minutes under stirring, then adding 50 to 90 parts of benzenyl trichloride into the reactor, after addition, carrying out reactions for 45 to 60 minutes; then adding 100 to 200 parts of deionized water into the reactor, heating the materials in the reactor to a temperature of 90 to 100 DEG C, and carrying out reactions for 30 to 45 minutes to obtain a mixture (product); and step two, cooling the mixture to the room temperature, and transferring the mixture to a centrifuge to carry out centrifugal separation to obtain a solid namely D / L-dibenzoyl tartaric acid. The preparation method can largely improve the yield and reduces the production cost, generation of byproducts, and environmental pollution.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a preparation method of D / L-dibenzoyltartaric acid. Background technique [0002] D / L-dibenzoyl tartaric acid is a white crystalline powder with low price, stable properties and easy recycling. It is widely used as an intermediate of levamisole and chiral resolution amine compounds. It has good properties Industrial application value. [0003] In the prior art, a large amount of benzoic acid by-products can be produced in the synthetic process of D / L-dibenzoyltartaric acid, resulting in the purity of the finished product being usually less than 98.5%, the product yield can only reach 76%, and the production cost per ton of product is relatively high. High; and the generated benzoic acid by-products also need further recovery treatment, and in the current prior art, saline waste water will be produced in the process of benzoic acid by-products, which will pollute the e...

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Problems solved by technology

[0003] In the prior art, a large amount of benzoic acid by-products can be produced in the synthetic process of D / L-dibenzoyltartaric acid, resulting in the purity of the finished product being usually less than 98.5%, the product yield can only reach 76%, and the production cost per ton of product is relatively high. High; and the generated benzoic acid by-products also need further recovery treatment, and in the current prior art, saline waste water will be produced in the process of benzoic acid by-products, which will pollute the environment, thereby failing to meet people's requirements

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