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Preparation method and application of high quantum yield carbon quantum dot for NO detection

A carbon quantum dot, high-quantum technology, applied in the field of high quantum yield carbon quantum dot preparation, can solve the problems of high cytotoxicity and affecting cell survival rate, and achieve the effect of simple preparation process, short preparation time and easy repeatability

Active Publication Date: 2019-09-24
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some traditional fluorescent quantum dots contain heavy metal elements, which are highly toxic to cells and inevitably affect the survival rate of cells

Method used

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  • Preparation method and application of high quantum yield carbon quantum dot for NO detection
  • Preparation method and application of high quantum yield carbon quantum dot for NO detection
  • Preparation method and application of high quantum yield carbon quantum dot for NO detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Heat and dissolve 1.0g of o-phenylenediamine and 0.7g of citric acid in 10mL of deionized water to obtain a clear solution; move the obtained clear solution to a microwave oven with a microwave power of 700W, take it out after reacting for 3 minutes, and cool naturally to room temperature. Add 10 mL of deionized water to dissolve to obtain a cloudy liquid; centrifuge the cloudy liquid in a centrifuge for 10 min, and set the speed of the centrifuge to 9000 rpm. After centrifugation, filter with a pinhole filter with a pore size of 0.22 μm to obtain a clear carbon quantum dot solution. Then further dialysis with a 3500DA dialysis bag for 48 hours to remove soluble impurities to obtain a relatively pure carbon quantum dot solution.

[0036] Performance test of carbon quantum dots: transmission electron microscope pictures of carbon quantum dots such as figure 1 As shown, the distribution of carbon quantum dots prepared by this method is uniform, and the particle size is a...

Embodiment 2

[0039] Except changing the amount of citric acid in embodiment 1 into 1.2g, other implementation methods are the same as embodiment 1.

Embodiment 3

[0041] Except changing the microwave reaction time into 2min in Example 1, other implementation methods are the same as Example 1.

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Abstract

The invention relates to a preparation method and application of a high quantum yield carbon quantum dot for NO detection. The preparation method comprises the following steps: using a composition of two organic substances as a carbon source, and heating and dissolving the composition in water to obtain a mixed solution, wherein the organic substances are selected from o-phenylenediamine and citric acid, and a mass ratio of o-phenylenediamine to citric acid is 0.7-1.2:0.5-1.0; placing the mixed solution in a microwave oven, carrying out a reaction for 2-5 min with a microwave power of 600-800 W, and performing natural cooling to obtain a black block solid; adding water to the black block solid and performing stirring and dissolving to obtain a suspension, and preforming centrifugal separation and purification on the suspension; and taking the centrifuged solution, performing filtering to obtain a carbon quantum dot solution, and performing dialysis to remove impurities to obtain a relatively pure carbon quantum dot solution. The carbon quantum dot rapidly prepared by the provided method can be used as a fluorescent probe for detecting NO concentration in a solution and imaging of tumor cells.

Description

technical field [0001] The invention belongs to the field of carbon quantum dot preparation, and in particular relates to a method for preparing carbon quantum dots with high quantum yield for NO detection and an application thereof. Background technique [0002] Carbon quantum dots (carbon quantum dots, CQDs) is a new type of carbon nanomaterials with a size below 10nm and good photoluminescent properties. Since the discovery of carbon quantum dots, due to their unique properties, they have aroused great interest of researchers. Carbon quantum dots have excellent properties different from traditional quantum dots, such as good water solubility, chemical inertness, low toxicity, easy functionalization, photobleaching resistance and photostability, etc., and have broad applications in optoelectronic devices, biological detection, medicine and other fields application prospects. [0003] The existing synthesis methods of carbon quantum dots can be divided into two categories...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y40/00G01N21/64
CPCC09K11/65B82Y20/00B82Y40/00G01N21/6428G01N21/6486
Inventor 丁莉芸吴伟林海涛余莎徐冰黄俊
Owner WUHAN UNIV OF TECH