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Preparation method and application of fluorescent probe based on self-assembled micelle

A micellar and fluorescent technology, applied in the field of nanomaterials, can solve the problems of complex preparation process, limited expansion of its application, complicated purification steps, etc., and achieve the effect of simple preparation process, excellent luminescence characteristics, and high carbon content

Active Publication Date: 2019-10-11
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in some cases, block copolymers can be luminescent or fluorescent and / or biodegradable, making them useful for various biological applications, but this method requires the use of block copolymers, and the preparation process is complicated. The purification steps are complicated, which limits the expansion of its application
[0005] At present, there are still some defects in the preparation of fluorescent micelles. How to develop a new and simple preparation method of fluorescent micelles is of great significance for its application.

Method used

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  • Preparation method and application of fluorescent probe based on self-assembled micelle
  • Preparation method and application of fluorescent probe based on self-assembled micelle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] This example prepares fluorescent micelles by the following method

[0050] Mix nonanoic acid with water, the stirring speed is 100rpm, and the stirring time is 5min, to obtain a nonanoic acid aqueous solution with a concentration of 60mM, and then carry out rotary steaming, the rotary steaming temperature is 50°C, and the rotary steaming time is 2h. After the reaction is completed, without any Fluorescent micelles were obtained directly after separation, and the binding efficiency between FCNs and micelles was (100%).

[0051] The fluorescent micelles prepared in Example 1 were characterized by transmission electron microscopy, and the specific results were as follows figure 2 shown. pass figure 2 It can be seen that the shape of the prepared fluorescent micelles is worm-like and regular, the length distribution is in the range of 100nm-280nm, and the width distribution is in the range of 18nm-70nm.

Embodiment 2

[0053] This example prepares fluorescent micelles by the following method

[0054] Mix polyether ketone with water, the stirring speed is 600rpm, and the stirring time is 15min to obtain a polyether ketone aqueous solution with a concentration of 5mM, and then carry out vacuum distillation, the vacuum distillation is 30°C, and the vacuum distillation time is 48h. , the fluorescent micelles were directly obtained without any separation, and the binding efficiency of FCNs and micelles was (80%).

Embodiment 3

[0056] This example prepares fluorescent micelles by the following method

[0057] Mix polyacrylamide with water, the stirring speed is 10rpm, and the stirring time is 60min, to obtain a polyacrylamide aqueous solution with a concentration of 1000mM, and then perform rotary steaming, the rotary steaming temperature is 120°C, and the rotary steaming time is 0.1h. After the reaction is completed, Fluorescent micelles were obtained directly without any separation, and the binding efficiency between FCNs and micelles was (90%).

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Abstract

The invention provides a preparation method and application of a fluorescent probe based on a self-assembled micelle. The preparation method includes subjecting an aqueous solution of amphiphilic molecules to heat treatment to obtain a fluorescent micelle. The invention also provides the fluorescent micelle prepared by the preparation method and application of the fluorescent micelle. The preparation method of the fluorescent micelle has the advantages that the amphiphilic molecules directly form fluorescent carbon nanoparticles (FCNs) and the micelle through simple heat treatment, and the in-situ synthesis rate of the two can reach 100%; by a conventional self-assembly method for coating with coloring agents and modifying the amphiphilic molecules by fluorescent molecules, the modification rate for the amphiphilic molecules by the coloring agents and the fluorescent molecules is far lower than 100%. The fluorescent micelle can be used as a photoelectric material, a biological imagingagent, a diagnostic sensor, a drug transport material, a catalytic material, or an adsorptive degradation material for water treatment, thereby having a broad application prospect.

Description

technical field [0001] The invention belongs to the field of nanomaterials and relates to a preparation method and application of a self-assembled micelle-based fluorescent probe, in particular to a fluorescent micelle and its preparation method and application. Background technique [0002] Micelles are surfactants that are dissolved in water, and when the concentration is low, they are monomolecularly dispersed or adsorbed on the surface of the solution to reduce the surface tension. When the concentration of the surfactant increases to the point where the surface of the solution is saturated and cannot be re-adsorbed, the molecules of the surfactant begin to transfer into the solution, because the hydrophobic part of the surfactant molecule has a small affinity with water, while the hydrophilic part The attraction between them is relatively large. When a certain concentration is reached, the hydrophobic parts of many surfactant molecules will attract each other and associ...

Claims

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Application Information

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IPC IPC(8): C09K11/65C09K11/02G01N21/64
CPCC09K11/025C09K11/65G01N21/6486
Inventor 赵赫代琴曹宏斌
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI