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Aerobic fermentation systems and methods

A technology of aerobic fermentation and aeration system, which is applied in the fields of biochemical equipment and methods, sterilization methods, bioreactor/fermenter combinations, etc.

Pending Publication Date: 2019-10-11
DOW GLOBAL TECH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Embodiments of the present disclosure relate to aerobic fermentation systems and methods using large volume vessels for aerobic fermentation with greater production capacity

Method used

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  • Aerobic fermentation systems and methods
  • Aerobic fermentation systems and methods
  • Aerobic fermentation systems and methods

Examples

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example

[0092] The following examples are provided to illustrate the performance of various aspects of the systems 100, 200 described in this disclosure.

example 1

[0094] aeration oxygen mass transfer

[0095] Experiments were performed to determine the volumetric mass transfer coefficient k for delivery throughout the vessel of an aerobic fermentation system L a is 0.1 / s(s -1 ) is an appropriate magnification standard. Experiments were conducted in an 1800 gallon vessel with an aeration system fluidly coupled to the vessel. The inner diameter D of the container is 66 inches and the height H of the straight side V is 120". Change the height H of the liquid in the container by adding more liquid to the container or draining a portion of the existing contents. Between 3 feet and 8 feet of liquid corresponding to an aspect ratio (H / D) of 0.55 to 1.5 Experiments were carried out at a range of heights H. In each experiment, the liquid used was water at a nominal temperature of 18°C ​​to 20°C. Air was introduced into the vessel through an air sparger with a nominal outside diameter of approximately 50 inches, and used Pneumatically control...

example 2

[0109] Oxygen mass transfer in a recirculation loop with a static mixer

[0110] Increasing the oxygen mass transfer rate by circulating the fermentation composition through the recirculation loop 108 can provide improved performance during certain stages of the aerobic fermentation process. For example, this occurs during the growth phase of a microbial population (microorganisms), when compared to conventional operation of an aerobic fermentation process, a much greater oxygen mass transfer rate is required to maintain an oxygen mass transfer rate equal to or greater than that achieved by microorganisms When metabolism consumes the level of dissolved oxygen. As previously discussed herein, limiting the length of the recirculation can reduce fouling of recirculation loop surfaces. This means that the residence time of the fermented composition in the recirculation loop is shorter. Thus, recirculation can be designed to provide greater oxygen transfer rates than aeration sys...

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Abstract

A system for aerobic fermentation includes a vessel, an aeration system including a gas sparger fluidly coupled to the vessel to introduce a compressed gas to an internal volume of the vessel, and a recirculation loop fluidly coupled to an outlet of the vessel. The recirculation loop includes an eductor fluidly coupled to an oxygen-containing gas source, a static mixer downstream of the eductor, aheat exchanger downstream of the eductor, and a distributor downstream of the heat exchanger. The distributor is fluidly coupled to the vessel. The aeration system provides mixing and oxygen mass transfer to the fermentation composition in the vessel. The fermentation composition passes through the eductor, static mixer, heat exchanger, and distributor of the recirculation loop, and back into thevessel. Oxygen is transferred from an oxygen containing gas to the fermentation composition and heat is removed from the fermentation composition in the recirculation loop.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 469,796, filed March 10, 2017, the entire contents of which are incorporated herein by reference. technical field [0003] Embodiments of the present disclosure relate generally to aerobic fermentation systems and methods, and in particular to aerobic fermentation systems for performing aerobic fermentation at greater production rates in large volume vessels. Background technique [0004] Fermentation can be used to convert organic matter into one or more compounds through the microbial metabolism of microorganisms. These compounds are recovered from the fermentation broth as commercial products or as raw materials or intermediates for further processing. Conducting the fermentation process in the presence of oxygen to create aerobic conditions can be referred to as aerobic fermentation. The success of an aerobic fermentation process depe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/02
CPCC12M27/00C12M29/06C12M29/18C12M29/26C12M41/18C12M29/24C12M37/00C12M1/00
Inventor K·K·卡尔S·S·德什潘德J·J·普雷斯勒B·F·马丁斯I·R·M·托皮卡D·C·罗森菲尔德J·R·比格斯
Owner DOW GLOBAL TECH LLC
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