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High-purity extraction method of traditional Chinese medicine effective components

A technology of active ingredients and extraction method, applied in the field of high-purity extraction of active ingredients of traditional Chinese medicine, can solve the problems of allergic reactions, side reactions, and many impurities in wolfberry extracts.

Pending Publication Date: 2019-10-15
BEIJING BENCAO FANGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] The present inventor, on the basis of systematic research, through cooperative development, aimed at the problem that there are many impurities in the wolfberry extract obtained by the conventional wolfberry extraction method at present, especially the introduction of many unknown impurities (such as degradation in the extraction process) in the extract preparation process. product) and sensitizing impurities, some impurities can lead to the risk of side effects, especially for some allergic people, allergic reactions may occur, the inventors have proposed the following technical solutions through in-depth research and cooperative development, so that Solve the above technical problems

Method used

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  • High-purity extraction method of traditional Chinese medicine effective components
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  • High-purity extraction method of traditional Chinese medicine effective components

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Experimental program
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Embodiment 1

[0069] Take fresh wolfberry (origin Ningxia Zhongwei), crush it, add 0.1wt% papain to the dispersed wolfberry pulp, enzymolyze it at pH = 6.5 and 55°C for 0.5-1h, and then take n-butyl Alcohol and chloroform 4:1:0.5 (volume ratio) mixed solution, this mixed solution is added in the Lycium barbarum pulverized by pressing, violently shakes 320-60min, then centrifuges, discards the water layer, then removes the solvent under reduced pressure, then Reflux with chloroform: methanol 5:1 v / v mixture solution for 30min, filter, add ethanol to the filtered residue to reflux, heat to reflux for 10min, reflux with petroleum ether for 10min in a Soxhlet extractor, filter, and dry the residue. Then use 80° C. hot water to extract the water-soluble polysaccharide mixture from the residue to obtain a wolfberry extract solution. Ginseng extract extract (self-made) is carried out column chromatographic separation, and the chromatographic column used is the reversed-phase stationary phase mater...

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Abstract

The invention provides a high-purity extraction method of traditional Chinese medicine effective components. Extraction is mainly in accordance with a Chinese wolfberry fruit extract. Through the adoption of the method, impurities and sensitization components can be effectively removed, and compound recipe granules prepared through the extract have the advantage of being small in side effects.

Description

technical field [0001] The invention belongs to the technical field of granule preparation, and more specifically relates to a high-purity extraction method for effective components of traditional Chinese medicines. Background technique [0002] Lycium barbarum is the dry and mature fruit of Lycium barbarum Ningxia, a plant in the Solanaceae family. Lycium barbarum extract polysaccharide (LBP) is one of the main active ingredients in Lycium barbarum. It is a water-soluble proteoglycan, which has been proved to have anti-aging, improving immunity, lowering blood fat, anti-fatty liver and other effects. Over the past few decades, glycoconjugates from Lycium barbarum fruit (Lycium barbarum) have attracted much attention for their potential health-promoting effects. In addition, according to the in vitro, in vivo and clinical studies of the hypoglycemic and hypolipidemic effects of the isolated LBP fractions, these purified components of Lycium barbarum may be used as adjuvants...

Claims

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Application Information

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IPC IPC(8): A23L33/105
CPCA23L33/105A23V2002/00A23V2250/21
Inventor 周景春吴金昱
Owner BEIJING BENCAO FANGYUAN PHARMA CO LTD