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A kind of long-chain soluble chitosan and preparation method thereof

A technology of chitosan and chitosan solution, applied in the field of medicine, can solve the problems of inability to directly dissolve in water, limited application and the like

Active Publication Date: 2021-12-24
NMS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan is only soluble in acidic aqueous solution and cannot be directly dissolved in water, which limits its application.

Method used

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  • A kind of long-chain soluble chitosan and preparation method thereof
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  • A kind of long-chain soluble chitosan and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1: the invention provides a kind of preparation method of long-chain easily soluble chitosan, comprises the following steps:

[0024] 1) Put 50 mmol of dibromoethane and 10 mmol of N,N-dimethylethylamine into 30 mL of acetonitrile, purify with nitrogen, stir at 50°C for 16 hours, and then reflux for 1 hour. The solvent was evaporated to dryness and washed with ether. A white paste was obtained, which was dried at 35°C for 48 hours to obtain the terminal bromide quaternary ammonium salt a.

[0025] 2) Disperse 1 g of chitosan in 30 mL of DMSO, and stir for 1 hour at 85 ° C with nitrogen gas to obtain a chitosan solution; add 5 mmol of the synthesized terminal brominated quaternary ammonium salt a to dissolve in 10 mL of DMSO, and slowly drop into the above Chitosan solution was maintained at 85°C and stirred for 8 hours to obtain a crude product. The crude product was filtered in acetone at 25°C, precipitated and washed with acetone at 40°C. Dry at 40°C for...

Embodiment 2

[0026] Embodiment 2: the present invention provides a kind of preparation method of long-chain easily soluble chitosan, comprises the following steps:

[0027] 1) Put 50 mmol of dibromopropane and 10 mmol of N,N-dimethyloctylamine into 30 mL of acetonitrile, purify with nitrogen, stir at 50°C for 16 hours, and then reflux for 1 hour. The solvent was evaporated to dryness and washed with ether. Obtain a white paste, dry, and dry at 35°C for 48 hours to obtain terminal bromide quaternary ammonium salt b.

[0028] 2) Disperse 1 g of chitosan in 40 mL of DMSO, and stir at 85° C. for 1 hour by blowing nitrogen gas. Add 5 mmol of the synthesized terminal bromide quaternary ammonium salt b to be dissolved in 10 mL of DMSO, slowly drop into the above-mentioned chitosan solution, maintain 85° C. and stir for 8 hours to obtain a crude product. The crude product was filtered in acetone at 25°C, precipitated and washed with acetone at 40°C. Dry at 40°C for 24 hours. Finally, Soxhlet e...

Embodiment 3

[0029] Embodiment 3: the present invention provides a kind of preparation method of long-chain easily soluble chitosan, comprises the following steps:

[0030] 1) Put 50 mmol of dibromobutane and 10 mmol of N,N-dimethyldodecylamine into 30 mL of acetonitrile, purify with nitrogen, stir at 50°C for 16 hours, and then reflux for 1 hour. The solvent was evaporated to dryness and washed with ether. Obtain white paste, dry, and dry at 35 ℃ for 48 hours to obtain terminal bromide quaternary ammonium salt c.

[0031] 2) Disperse 1 g of chitosan in 50 mL of DMSO, and stir at 85° C. for 1 hour by blowing nitrogen gas. Add 5 mmol of the synthesized terminal bromide quaternary ammonium salt c to be dissolved in 10 mL of DMSO, slowly drop into the above chitosan solution, keep stirring at 85° C. for 8 hours to obtain a crude product. The crude product was filtered in acetone at 25°C, precipitated and washed with acetone at 40°C. Dry at 40°C for 24 hours. Finally, Soxhlet extraction wa...

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Abstract

The invention provides a long-chain easily soluble chitosan and a preparation method thereof. In the method, dibromoalkane and N,N-dimethylalkylamine are mixed, dissolved in acetonitrile, purified by passing nitrogen gas, and reacted , to obtain quaternary brominated ammonium salt; then chitosan was dissolved in DMSO, and stirred with nitrogen to obtain a chitosan solution; the quaternary brominated ammonium salt was slowly added to the chitosan solution and stirred to obtain a crude product; the The crude product is filtered, precipitated, washed, dried, and finally used for Soxhlet extraction, and dried to obtain the target product. The long-chain easily soluble chitosan prepared by the invention can kill Staphylococcus aureus, Escherichia coli and Candida albicans, and the sterilization rate can reach more than 99%.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a long-chain soluble chitosan and a preparation method thereof. Background technique [0002] The antibacterial function modification of the material surface can prevent the growth of harmful microorganisms, which is of great significance to control the spread of germs and protect the material body from microbial corrosion. Therefore, the research on antibacterial agents and antibacterial functional materials has been widely concerned by researchers. Quaternary ammonium compounds are favored because of their excellent properties such as low toxicity, low price, and broad antibacterial spectrum. At present, quaternary ammonium salt antibacterial agents have been developed to the sixth generation - quaternary ammonium salt polymer antibacterial agents, because of their higher charge density, they have stronger antibacterial ability than small molecule compounds. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A01N43/16A01N33/12A01P1/00A01P3/00
CPCC08B37/003A01N43/16A01N33/12
Inventor 蔡友良黄龙强浩
Owner NMS TECH
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