Antibacterial hydrogel for women and preparation method of antibacterial hydrogel for women

A technology of antibacterial water and temperature-sensitive hydrogel, which is applied in the field of medicine, can solve the problems of serious drug resistance of fungi, adverse reactions, and insufficient antibacterial spectrum, and achieve long duration, short antibacterial time and long bactericidal effect Effect

Inactive Publication Date: 2019-03-29
NMS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

) In addition, there are some suppositories and lotions, etc., but most of the drugs will be damaged to a certain extent on the female vaginal environment and the secretion of the mucous membrane itself
Moreover, although the antifungal drugs used play a huge role in effectively controlling fungal infections, their antibacterial spectrum is not wide enough and most of them have adverse reactions. In addition, fungal drug resistance is becoming more and more serious, resulting in continuous recurrence of inflammation.
This leads to great challenges in antifungal drug therapy

Method used

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  • Antibacterial hydrogel for women and preparation method of antibacterial hydrogel for women
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  • Antibacterial hydrogel for women and preparation method of antibacterial hydrogel for women

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Effect test

Embodiment 1

[0028] Embodiment 1: the present invention provides a kind of preparation method of women's antibacterial hydrogel, comprising the following steps:

[0029] 1) After mixing the gel base and the moisturizer at a mass volume ratio of 1g: 1.2mL, solution A is obtained;

[0030] 2) Mix the organic silicon quaternary ammonium salt and deionized water according to the mass volume ratio of 1g:45mL, and obtain solution B after emulsification;

[0031] 3) Mix solution A and solution B according to the mass volume ratio of 1g:2.5ml, and obtain solution C after swelling;

[0032] 4) Adjust the pH of solution C to 4 with acetic acid to obtain a drug-loaded thermosensitive hydrogel.

Embodiment 2

[0033] Embodiment 2: the present invention provides a kind of preparation method of women's antibacterial hydrogel, comprising the following steps:

[0034] 1) After mixing the gel matrix and the moisturizing agent at a mass volume ratio of 1g: 3.5mL, solution A is obtained;

[0035] 2) Mix organic silicon quaternary ammonium salt and deionized water according to the mass volume ratio of 1g: 55.5mL, and obtain solution B after emulsification;

[0036] 3) Mix solution A and solution B according to the mass volume ratio of 1g: 3.8mL, and obtain solution C after swelling;

[0037] 4) Adjust the pH of solution C to 5.5 with lactic acid to obtain a drug-loaded thermosensitive hydrogel.

Embodiment 3

[0038] Embodiment 3: the present invention provides a kind of preparation method of antibacterial hydrogel for women, comprising the following steps:

[0039] 1) After mixing the gel base and the moisturizing agent in a mass volume ratio of 1g: 4.8mL, solution A is obtained;

[0040] 2) Mix organic silicon quaternary ammonium salt and deionized water according to the mass volume ratio of 1g: 60.9mL, and obtain solution B after emulsification;

[0041] 3) Mix solution A and solution B according to the mass volume ratio of 1g:4.3mL, and obtain solution C after swelling;

[0042] 4) Adjust the pH value of solution C to 6.5 with hydrochloric acid to obtain a drug-loaded thermosensitive hydrogel.

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Abstract

The invention provides antibacterial hydrogel for women and a preparation method of the antibacterial hydrogel for women. The method comprises the following steps of firstly, mixing a gel substrate with a hydrating agent for dissolving to obtain a solution A; secondly, enabling organosilicon quaternary ammonium salt to dissolve in deionized water, and performing emulsifying to obtain a solution B;slowly adding the solution A to the solution B, and performing swelling to obtain a solution C; and regulating the pH of the solution C with an acidulant until the solution C is in the weak acid range being 4-6.5, so as to obtain medicine-carried thermo-sensitive hydrogel. The antibacterial hydrogel for women has long-acting physical bacterium resistance, and has effects of moisturizing and moistening skin, improving microcirculation, promoting cell metabolism, and adjusting the pH value of vagina. Experiment proves that the prepared antibacterial hydrogel for women can kill staphylococcus aureus, bacillus coli and blastomyces albicans, and the sterilization rate achieves 99% or above. In addition, when the gel is used, the skin is free from allergy, and the gel has light irritating on skin and vaginal mucosa.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antibacterial hydrogel for women and a preparation method thereof. Background technique [0002] Human skin and mucous membranes are a natural physiological defense line to resist the invasion of pathogenic microorganisms. The female vagina is extremely prone to breed microorganisms, destroying its stable colony environment, and even causing lesions. Thereby leading to the generation of various vaginal diseases. Such as vaginitis, cervicitis and so on. [0003] There are many therapeutic drugs currently used clinically, including oral agents (absorbed through the stomach, blood circulation reaches the vagina to kill bacteria, but the general cycle is relatively long, and the drug effect is also very low.) There are also some suppositories and lotions, etc. in addition, but Most of the drugs will damage the female vaginal environment and the secretion of the muc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/695A61P15/00A61P15/02A61P31/10A61P31/02A61P31/04
CPCA61K9/0034A61K9/06A61K31/695A61P15/00A61P15/02A61P31/02A61P31/04A61P31/10
Inventor 蔡友良贺云
Owner NMS TECH
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