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Application of MSN/miRNA hydrogel in preparing medicine for treating myocardial infarction

A myocardial infarction, hydrogel technology, applied in the preparation of drugs for the treatment of myocardial infarction, in the field of MSN/miRNA hydrogel, can solve the problem of no help for myocardial cells, achieve stable therapeutic effect, promote vascularization, and reduce the range of Effect

Active Publication Date: 2019-10-22
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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Problems solved by technology

However, suppressing the immune response in the acute phase only reduces ongoing damage and does not help "at-risk" cardiomyocytes in the ischemic region of the heart

Method used

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  • Application of MSN/miRNA hydrogel in preparing medicine for treating myocardial infarction

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Embodiment Construction

[0020] The present invention will be further described below in conjunction with specific embodiments, but the embodiments are only exemplary and do not constitute any limitation on the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solution of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements fall within the protection scope of the present invention.

[0021] 1. The preparation method of MSN / miRNA hydrogel includes the following steps:

[0022] (1) Configuration of injectable hydrogel A / B solution:

[0023] The configuration of A solution: Weigh 0.1g CHO-PEG5k-CHO in the sample tube, add 500μL ultrapure water, dissolve by ultrasonic, and set aside.

[0024] Configuration of B solution: Weigh 0.05g alpha-CD in the sample tube, add 500μL ultrapure water, dissolve by ultrasonic, and set aside.

[0025] (2) P...

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Abstract

The invention discloses application of MSN / miRNA hydrogel in preparing medicine for treating myocardial infarction. The MSN is porous mesoporous silicon nanospheres, and the miRNA is miR-21. The hydrogel has the following advantages that 1, through modification of amine functional groups on the surfaces of the MSN nanospheres, a Schiff base reaction with aldehyde groups in hydrocolloid is conducted, thereby achieving precise treatment by using a weakly acidic environment of the myocardial infarction; 2, the aldehyde groups in the hydrocolloid can tightly adhere to cardiac muscle tissue in a treatment area, thereby achieving a stable therapeutic effect; 3, the MSN nanospheres regulate the immune response, thereby improving the reconstruction function of the cardiac muscle tissue; 4, miR-21micromolecules are delivered, thereby promoting local vascularization in a myocardial infarction area, thereby reducing the myocardial infarction size. Therefore, the hydrogel has important application value in treating the myocardial infarction.

Description

Technical field [0001] The invention belongs to the technical field of medical applications, and specifically relates to the application of MSN / miRNA hydrogel in preparing medicines for treating myocardial infarction. Background technique [0002] Myocardial infarction is currently the highest mortality disease in the world. Early intervention can improve the survival rate of inpatients. However, most patients often die from chronic heart failure after discharge. The main reason is the scar formation in the area of ​​myocardial infarction. To a large extent affect the function of the heart. Scarring is mainly due to the acute phase inflammatory reaction of the heart after ischemia and hypoxia, which leads to further connective tissue hyperplasia. Therefore, many scholars currently try to reduce the inflammatory response in the acute phase after myocardial infarction by inhibiting the activity of immune cells. However, these technologies have only achieved certain results in anim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/61A61K47/60A61K47/52A61K31/7088A61P9/10
CPCA61K47/6903A61K47/60A61K47/61A61K47/52A61K31/7088A61P9/10
Inventor 李岩陈鑫邹多宏杨驰张志愿
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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