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Application of msn/mirna hydrogel in preparation of medicine for treating myocardial infarction

A myocardial infarction, hydrogel technology, applied in the preparation of drugs for the treatment of myocardial infarction, in the field of MSN/miRNA hydrogel, can solve the problem of no help for myocardial cells, achieve stable therapeutic effect, reduce the range, and promote vascularization Effect

Active Publication Date: 2022-06-14
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Claims
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Problems solved by technology

However, suppressing the immune response in the acute phase only reduces ongoing damage and does not help "at-risk" cardiomyocytes in the ischemic region of the heart

Method used

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  • Application of msn/mirna hydrogel in preparation of medicine for treating myocardial infarction

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Embodiment Construction

[0020] The present invention will be further described below in conjunction with specific embodiments, but the embodiments are only exemplary and do not constitute any limitation to the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0021] 1. The preparation method of MSN / miRNA hydrogel includes the following steps:

[0022] (1) Configuration of injectable hydrogel A / B solution:

[0023] Configuration of solution A: Weigh 0.1 g of CHO-PEG5k-CHO in a sample tube, add 500 μL of ultrapure water, dissolve by ultrasonic, and set aside for use.

[0024] Configuration of solution B: Weigh 0.05g of alpha-CD in a sample tube, add 500 μL of ultrapure water, dissolve by ul...

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Abstract

The invention discloses the application of MSN / miRNA hydrogel in the preparation of medicine for treating myocardial infarction, wherein MSN is porous mesoporous silicon nanometer microsphere, and miRNA is miR-21. The hydrogel has the following advantages: 1. Through the modification of the amine functional group on the surface of MSN nano-microspheres, it can react with the Schiff base of the aldehyde group in the hydrocolloid, thereby using the weak acidic environment of myocardial infarction to achieve precise treatment; 2. It can be tightly attached to the myocardial tissue in the treatment area through the aldehyde group in the hydrocolloid, so as to achieve a stable therapeutic effect; 3. It can regulate the immune response through MSN nanospheres to improve the reconstruction function of myocardial tissue; 4. It can deliver miR‑ 21 small molecules, promote local vascularization of myocardial infarction area, thereby reducing the extent of myocardial infarction. Therefore, the hydrogel of the present invention has important application value in the treatment of myocardial infarction.

Description

technical field [0001] The invention belongs to the technical field of medical applications, and particularly relates to the application of MSN / miRNA hydrogel in the preparation of a drug for treating myocardial infarction. Background technique [0002] Myocardial infarction is currently the disease with the highest mortality rate in the world. Early intervention can improve the survival rate of inpatients. However, most patients often die of chronic heart failure after discharge. The main reason is that the scarring in the myocardial infarction area is very difficult. greatly affects the function of the heart. Scar formation is mainly due to the hyperplasia of further connective tissue caused by the inflammatory response of the heart in the acute phase after ischemia and hypoxia. Therefore, many scholars have tried to reduce the inflammatory response in the acute phase after myocardial infarction by inhibiting the activity of immune cells. However, these techniques have on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/61A61K47/60A61K47/52A61K31/7088A61P9/10
CPCA61K47/6903A61K47/60A61K47/61A61K47/52A61K31/7088A61P9/10
Inventor 李岩陈鑫邹多宏杨驰张志愿
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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