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Chuanxiong rhizome oil microcapsule and preparation method thereof, and chuanxiong rhizome oil microcapsule gel patch and preparation method thereof

A technology of microcapsule gel patch and Ligusticum chuanxiong oil, which is applied in the field of medicine, can solve the problems of thermal instability, easy volatilization, and easy oxidation, and achieve the effects of improving stability, no skin irritation, and high encapsulation efficiency

Inactive Publication Date: 2019-11-12
SOUTHWEST UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Modern studies have shown that the volatile oil of traditional Chinese medicine has a variety of clear pharmacological activities, and has a certain degree of penetration-promoting effect. It is fat-soluble and not easily miscible with water-soluble gel patch matrix, resulting in "oily" phenomenon

Method used

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  • Chuanxiong rhizome oil microcapsule and preparation method thereof, and chuanxiong rhizome oil microcapsule gel patch and preparation method thereof
  • Chuanxiong rhizome oil microcapsule and preparation method thereof, and chuanxiong rhizome oil microcapsule gel patch and preparation method thereof
  • Chuanxiong rhizome oil microcapsule and preparation method thereof, and chuanxiong rhizome oil microcapsule gel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] In this example, the effects of different concentrations of gelatin aqueous solution on the properties of Chuanxiong oil microcapsules were investigated. The preparation method of the Chuanxiong oil microcapsules of this embodiment is specifically:

[0060] Step 1. Accurately weigh gelatin and gum arabic respectively, pipette 100ml of pure water, ultrasonicate for 30 minutes, and then bathe in water at 50°C for 30 minutes to completely dissolve gelatin and gum arabic to obtain gelatin aqueous solution and gum arabic aqueous solution;

[0061] Step 2. Add 1.0g Chuanxiong oil to the aqueous gelatin solution, and emulsify at 18000rpm for 5min to obtain a gelatin-Chuanxiong oil emulsion;

[0062] Step 3. Slowly add an aqueous solution of gum arabic to the gelatin-Chuanxiong oil emulsion, wait for the temperature of the solution to rise to 50°C, and stir it magnetically for 1 hour; then add twice the volume of the mixed solution of pure water at 50°C to reduce the viscosity ...

Embodiment 2

[0082] This embodiment investigates the impact of different concentrations of gum arabic aqueous solution on the properties of microcapsules, specifically:

[0083] Accurately weigh 1, 2, 2.5, 3, 4, 5g gum arabic gum respectively, add 100ml pure water, obtain 1%, 2%, 2.5%, 3%, 4%, 5% gum arabic solution, gelatin solution 3.0%. The microcapsules were prepared according to the method of Example 1, and other parameters were kept constant, and the influence of different gum arabic solution concentrations on the properties of the microcapsules was investigated. The results are shown in Table 2:

[0084] Table 2 Effects of Gum Arabic Solution with Different Concentrations on the Properties of Microcapsules

[0085] concentration 1％ 2％ 2.5％ 3％ 4％ 5％ Encapsulation rate (%) 41.06 42.11 75.23 80.11 - - Drug loading(%) 15.22 12.56 13.75 27.47 - - Sedimentation rate (%) 56.49 76.74 78.01 83.56 - -

[0086] It can be seen from the abo...

Embodiment 3

[0088] In this example, the influence of different emulsification rotational speeds on the properties of microcapsules is investigated, specifically:

[0089] Prepare microcapsules according to the method of Example 1, wherein in step 1, the mass concentration of the gelatin aqueous solution and the gum arabic aqueous solution are both set to 3%, and the emulsification speed is set to 12000, 15000, 18000 rpm respectively, and other parameters remain unchanged. Observe the emulsification speed Effect on Microcapsule Morphology. The results are shown in Table 3:

[0090] Table 3 Effect of emulsification rotation speed on properties of microcapsules

[0091]

[0092]

[0093] It can be seen from the experimental results that the rotational speed has little effect on the microencapsulation efficiency, and the particle size does not decrease with the increase of the emulsification rotational speed, which may be related to the electrostatic interaction between the gelatin-chu...

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Abstract

The invention discloses a chuanxiong rhizome oil microcapsule and a preparation method thereof, and a chuanxiong rhizome oil microcapsule gel patch and a preparation method thereof. The problems thattraditional Chinese medicine volatile oil is encapsulated into microcapsules, the encapsulation efficiency is low, stability is poor after encapsulation, and a gel patch is prone to 'extensive diffusion of oil' in the prior art are solved. The preparation method of the chuanxiong rhizome oil microcapsule includes the following steps that chuanxiong rhizome oil is added into a gelatin water solution for emulsification, then an Acacia gum water solution is added, heating up is conducted, and water is added after stirring; then an acid solution is added to make gelatin and Acacia gum agglomerateinto a capsule; and cooling, microcapsule sedimentation, washing, and freeze drying are conducted to obtain the chuanxiong rhizome oil microcapsule. The chuanxiong rhizome oil microcapsule gel patch is prepared from the following raw materials in parts by weight: the chuanxiong rhizome oil microcapsule, NP 700, glycerinum, dihydroxyaluminium aminoacetate, tartaric acid, a filling agent, PVPK 30, azone, and 0.5% of carbomer. The chuanxiong rhizome oil microcapsule has good stability and high encapsulation efficiency, and the chuanxiong rhizome oil microcapsule gel patch does not suffer from 'extensive diffusion of oil'.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to chuanxiong oil microcapsules and a preparation method, and chuanxiong oil microcapsule gel patch and a preparation method. Background technique [0002] Ligusticum chuanxiong is the dry rhizome of Ligusticum chuanxiong Hort. in the family Umbelliferae. It is mainly produced in Sichuan, Guizhou, and Yunnan, and Sichuan produces high-quality products. It is pungent in taste and warm in nature, and belongs to the Liver, Gallbladder, and Pericardium Meridians. It has the effects of promoting blood circulation and promoting qi, expelling wind and relieving pain, and is commonly used clinically for blood stasis and stagnant pain syndrome, headache, and rheumatic arthralgia. For the Qi medicine in the blood. "Materia Medica Huiyan": "Xiong Mei, ascending leader, down-regulating menstrual water, opening depression....", it is an important medicine for headache and gynecol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/42A61K47/36A61K9/70A61K47/32A61K36/236A61P29/00
CPCA61K9/5036A61K9/5057A61K9/7023A61K36/236A61K47/32A61P29/00
Inventor 杨荣平周欣周文杰赵崧钧
Owner SOUTHWEST UNIVERSITY
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