Device and method for separating circulating tumor cells and their microemboli by dual-frequency standing wave acoustic field
A technology of tumor cells and microemboli, applied in stress-stimulated microbial growth methods, enzymology/microbiology devices, biochemical cleaning devices, etc., can solve the problem of low separation efficiency of density gradient centrifugation, limited separation ability of bulk acoustic wave method, It is difficult to effectively guarantee cell viability and other issues, so as to avoid complicated operating procedures, improve precision and accuracy, and avoid cell blockage
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[0031] The specific embodiments and examples of the present invention will be described in detail below in conjunction with the accompanying drawings. The described specific embodiments are only used to explain the present invention, and are not intended to limit the specific embodiments of the present invention.
[0032] like figure 1 shown, figure 1 It is a working principle diagram of the core part of the embodiment of the device for separating circulating tumor cells and their microemboli using a dual-frequency standing wave sound field. The core part of the separation device consists of a flow channel base (not shown in the figure), a first piezoelectric A ceramic 310 and a second piezoelectric ceramic 320;
[0033] The flow channel base is provided with a first flow channel 100 for cooperating with the first piezoelectric ceramic 310 to separate circulating tumor cell CTCs and microembolus CTCs, and a second piezoelectric ceramic 320 for separating circulating tumor cel...
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