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Xuefuzhuyu capsule quality control marker discovery method based on content-stability-activity multidimensional network mode

A kind of technology of removing blood stasis and network mode, applied in measurement devices, instruments, scientific instruments, etc., can solve the problem of relatively few researches on quality control.

Active Publication Date: 2019-11-12
TIANJIN HONGRENTANG PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Xuefu Zhuyu Capsules are composed of 11 traditional Chinese medicines including safflower, peach kernel, red peony root, Chuanxiong, Achyranthes bidentata, angelica, shengdi, citrus aurantii, Bupleurum chinensis, platycodon grandiflorum, and licorice. less

Method used

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  • Xuefuzhuyu capsule quality control marker discovery method based on content-stability-activity multidimensional network mode
  • Xuefuzhuyu capsule quality control marker discovery method based on content-stability-activity multidimensional network mode
  • Xuefuzhuyu capsule quality control marker discovery method based on content-stability-activity multidimensional network mode

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1 Study on Determination of Multiple Components in Xuefu Zhuyu Capsules

[0083] 1.1 Materials and methods

[0084] 1.1.1 Instruments

[0085]

[0086] 1.1.2 Reagent

[0087] Protocatechuic acid (B21614), rutin (B20771), chlorogenic acid (B20782), ferulic acid (B20007), neohesperidin (B21390), hydroxysafflower yellow A (B20968), hesperidin ( B20182), p-hydroxybenzoic acid (B20328), paeoniflorin (B21148), naringin (B21594), naringenin (B21634), naringenin (B21596), rhodorin (B21484), liquiritin (B20414 ), Liquiritigenin (B20416), Glycyrrhizinic Acid (B20417), Neoisoliquiritin (B24043), and Ecdysone (B21268) were purchased from Shanghai Yuanye Biotechnology Co., Ltd. Paeonifloride (S-011-161028), Chuan Nobietin (C-015-150729) was purchased from Chengdu Ruifensi Biotechnology Co., Ltd., with a purity of ≥98%. The chemical structure is shown in Figure 1-1.

[0088] Safflower, red peony, citrus aurantium, angelica, peach kernel, chuanxiong, achyranthes bidenta...

Embodiment 2

[0113] Example 2 Study on Stability of Xuefu Zhuyu Capsule under Strong Light, High Temperature and High Humidity

[0114] 2.1 Materials and methods

[0115] 2.1.1 Instruments

[0116]

[0117]

[0118] 2.1.2 Drug testing

[0119] Protocatechuic acid (B21614), rutin (B20771), chlorogenic acid (B20782), ferulic acid (B20007), neohesperidin (B21390), hydroxysafflower yellow A (B20968), hesperidin ( B20182), p-hydroxybenzoic acid (B20328), paeoniflorin (B21148), naringin (B21594), naringenin (B21634), naringenin (B21596), rhodorin (B21484), liquiritin (B20414 ), glycyrrhizin (B20416), glycyrrhizic acid (B20417), neoisoliquiritin (B24043), ecdysone (B21268) (purity ≥ 98%) were purchased from Shanghai Yuanye Biotechnology Co., Ltd., paeonifloride (S- 011-161028), Nobiletin (C-015-150729) were purchased from Chengdu Ruifensi Biotechnology Co., Ltd., with a purity of ≥98%.

[0120] Xuefu Zhuyu Capsule (batch number: F03124) was provided by Tianjin Hongrentang Pharmaceutical...

Embodiment 3

[0158] Example 3 Study on Antioxidative and Anti-inflammatory Activities of Candidate Components of Xuefu Zhuyu Capsules

[0159] 3.1 Antioxidant activity research

[0160] 3.1.1 Materials and methods

[0161] 3.1.1.1 Instruments

[0162]

[0163] 3.1.1.2 Reagent

[0164] Protocatechuic acid (B21614), rutin (B20771), chlorogenic acid (B20782), ferulic acid (B20007), neohesperidin (B21390), hydroxysafflower yellow A (B20968), hesperidin ( B20182), p-hydroxybenzoic acid (B20328), paeoniflorin (B21148), naringin (B21594), naringenin (B21634), naringenin (B21596), rhodorin (B21484), liquiritin (B20414 ), Liquiritigenin (B20416), Glycyrrhizic Acid (B20417), Neoisoliquiritin (B24043), Ecdysone (B21268) (purity ≥ 98%) were purchased from Shanghai Yuanye Biotechnology Co., Ltd. Paeonifloride (S- 011-161028), Nobiletin (C-015-150729) were purchased from Chengdu Ruifensi Biotechnology Co., Ltd., with a purity of ≥98%.

[0165] Xuefu Zhuyu Capsules (batch number: F03103) were pro...

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Abstract

The invention relates to a Xuefuzhuyu capsule quality control marker discovery method based on a content-stability-activity multidimensional network mode. The method includes the following steps: stepone, obtaining a content dimension value of a Xuefuzhuyu capsule; step two, obtaining a stability value of the Xuefuzhuyu capsule; step three, obtaining an activity value of the Xuefuzhuyu capsule; and step four, constructing a content-stability-activity three-dimensional network for analysis, analyzing chemical components of the Xuefuzhuyu capsule by using regression areas of the three-dimensional network, and sorting the candidate components according to the regression areas to determine quality control markers of the Xuefuzhuyu capsule. The method selects the content, the stability and theactivity three dimensions of 20 candidate components of the Xuefuzhuyu capsule, constructs quality control marker analysis technology based on the content-stability-activity multidimensional networkmode, and evaluates comprehensive contribution of the candidate components in the compound by calculating the regression areas of the components, which provides a basis for optimizing quality controlindexes.

Description

technical field [0001] The invention belongs to the technical field of selection of quality markers of traditional Chinese medicines, and in particular relates to a method for discovering quality control markers of Xuefu Zhuyu Capsules based on a quantitative, stable, active and multi-dimensional network model. Background technique [0002] The quality control and evaluation of traditional Chinese medicine is a key scientific issue in the modernization of traditional Chinese medicine, and it is also an indispensable part of the development process of traditional Chinese medicine. Traditional Chinese medicine has the characteristics of complex and diverse chemical components, large content differences, wide range of pharmacological effects, and unclear mechanism. It is difficult to select the quality control indicators of Chinese medicine, and the current evaluation mode of quality control of Chinese medicine mainly refers to the quality control mode of chemical drugs, and the...

Claims

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Application Information

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IPC IPC(8): G01N30/86
CPCG01N30/8679
Inventor 宋纹王帆张慧
Owner TIANJIN HONGRENTANG PHARM CO LTD
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