Compositions and systems for renal function determination

Abstract

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computingdevice, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, andthe rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

Description

Background technique

[0001] The field disclosed herein relates generally to methods and pharmaceutical compositions comprising pyrazine derivatives for assessing renal function in a patient in need thereof.

[0002] Acute renal failure (ARF) is a common condition among patients admitted to general surgery hospitals. About half of patients who develop ARF die directly from ARF or from complications related to the underlying medical condition, while survivors experience significantly increased morbidity and prolonged hospital stay. Early diagnosis is generally considered important because kidney failure is often asymptomatic and often requires careful follow-up of markers of kidney function in the blood. Active monitoring of renal function in patients is required in order to minimize the risk of acute renal failure caused by various clinical, physiological and pathological conditions. Such dynamic monitoring is often particularly important in the case of critically ill or inju...

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