High-speed filtration preparation process of polypeptide donkey-skin gelatin plasma substitutes

A preparation process, the technology of donkey skin glue, applied in the field of medicine, can solve the problems of slow filtration speed, affecting production efficiency, high viscosity, etc., and achieve the effect of increased filtration speed and fast filtration speed

Inactive Publication Date: 2011-10-19
JIANGSU JIANZHONG INVESTMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Polypeptide donkey skin glue contains a large amount of macromolecular gelatin polypeptide, which has a high viscosity after being dissolved in water, and the filtration speed is very slow, which seriously affects the production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Select healthy and disease-free donkeys for cleaning, slaughtering, skinning, dehairing, and degreasing, soak in 2% sodium carbonate solution for 5 minutes, clean, decoct, concentrate, filter and separate, remove a small amount of fat on the surface and sediment at the bottom, and further Concentrate and dry into raw gum, dilute the raw gum with water, centrifuge, take the supernatant and refine it with cation exchange resin, filter to remove impurities, vacuum dry, and pack to obtain the polypeptide donkey skin glue.

[0021] Dissolve 250g of polypeptide donkey skin glue, 70g of sodium chloride in 20L of water for injection, adjust the pH value to 6.5, add 30g of activated carbon powder and boil for 30 minutes, then filter through a 0.45 micron microporous membrane with a diameter of 150mm under 0.2Mpa pressure at room temperature, The filtration time was examined, and it turned out that the filtration took 157 minutes.

[0022] Dissolve 250g of polypeptide donkey skin...

Embodiment 2

[0025] Select healthy and disease-free donkeys for cleaning, slaughtering, skinning, dehairing, and degreasing, soak in 2% sodium carbonate solution for 5 minutes, clean, decoct, concentrate, filter and separate, remove a small amount of fat on the surface and sediment at the bottom, and further Concentrate and dry into raw gum, dilute the raw gum with water, centrifuge, take the supernatant and refine it with cation exchange resin, filter to remove impurities, vacuum dry, and pack separately to obtain polypeptide donkey skin glue. The average molecular weight of polypeptide donkey skin glue is 15800.

[0026] Dissolve 250g of polypeptide donkey skin glue, 70g of sodium chloride, and 0.25g of leucine in 20L of water for injection, adjust the pH value to 6.5, add 30g of activated carbon powder and boil for 30 minutes, and make porous titanium with a diameter of 150 mm and a diameter of 0.45 microns under 0.2 Mpa pressure Rod filtration, the temperature of the polypeptide donkey ...

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PUM

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Abstract

The invention combines the polypeptide donkey-skin gelatins with different weight-average molecular weights and then adds tryptophan into the combined polypeptide donkey-skin gelatins to prepare the plasma substitutes containing gelatin molecules with different molecular weights. The process has the advantages that: smaller molecules can easily pass through renal glomerulus, which contributes to diuretics at the early stage of introduction; bigger molecules are left in the blood vessels, and the dilatation effect is prolonged; and the increase of the tryptophan can stimulate the synthesis of albumins so as to replenish the plasma proteins in huge loss.

Description

technical field [0001] The invention relates to a high-speed filtration preparation process of polypeptide donkey skin glue instead of plasma, which belongs to the technical field of medicine. Background technique [0002] As we all know, plasma is the liquid part of circulating blood, which is an aqueous solution containing serum proteins, inorganic salts, electrolytes, glucose and fibrinogen. In peacetime, especially during wartime, when the human body loses too much blood due to various reasons, plasma needs to be supplemented. The use of human blood plasma and blood products has become unsafe due to some blood-borne diseases such as hepatitis and AIDS. In addition, human blood sources are limited and expensive, so human blood sources alone cannot meet the needs of a large amount of blood. The development and development of plasma substitutes for non-human blood has become a matter of great concern and attention in the scientific and medical circles. [0003] Currently ...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61P7/08
Inventor 黄雄伟花亚光龚箭邹亚轩黄雄信
Owner JIANGSU JIANZHONG INVESTMENT
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