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Flos carthami Xiaoyao preparation for treating breast cancer as well as preparation method and application of flos carthami Xiaoyao preparation

A breast cancer and safflower technology, applied in the field of safflower xiaoyao preparation for treating breast cancer and its preparation, can solve the problems of effective treatment of unfavorable breast cancer, large side effects, numerous components, etc., so as to improve the comprehensive treatment effect and prevent recurrence. and metastatic, good therapeutic and inhibitory effects

Active Publication Date: 2019-11-26
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its raw materials include more than 40 components including woody incense, Cyperus cyperi, turmeric, and tangerine peel. Although they have the effect of inhibiting breast cancer, due to the large number of components, on the one hand, the cost is increased, and on the other hand, there are too many impurities. , its side effects are relatively large, and it is not conducive to giving full play to the efficacy of active ingredients
[0006] In addition, the Chinese patent application CN 103751702 A discloses a traditional Chinese medicine for treating breast cancer. Its components include more than 20 species including Trichosanthes chinensis, Astragalus membranaceus, Prunella vulgaris, oysters, Bupleuri, etc. There are also problems such as cost and side effects. , is not conducive to the effective treatment of breast cancer

Method used

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  • Flos carthami Xiaoyao preparation for treating breast cancer as well as preparation method and application of flos carthami Xiaoyao preparation
  • Flos carthami Xiaoyao preparation for treating breast cancer as well as preparation method and application of flos carthami Xiaoyao preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The safflower Xiaoyao preparation for the treatment of breast cancer described in this example includes the following raw materials in parts by weight: 165 parts of Angelica sinensis, 70 parts of Radix Paeoniae Alba, 147 parts of Atractylodes Rhizoma Atractylodes Rhizome, 45 parts of Poria cocos, 95 parts of safflower, saponin thorn 57 parts, 35 parts of bamboo leaf Bupleurum, 135 parts of mint, 70 parts of licorice.

[0038] The preparation method of the safflower Xiaoyao preparation for treating breast cancer comprises the following steps:

[0039] (1) After crushing safflower, licorice, and Bupleurum chinensis, add water to mix and extract, raise the temperature to 85°C for extraction for 1.5 hours, and then boil for 25 minutes; obtain water extract A and medicinal residue 1;

[0040] Take macroporous adsorption resin chromatography column: the upper layer is AB-8, the middle layer is NKA and the lower layer is NKA-9, wherein the thickness ratio of AB-8, NKA, NKA-9 i...

Embodiment 2

[0048] The safflower Xiaoyao preparation for treating breast cancer described in this example includes the following raw materials in parts by weight: 150 parts of Angelica sinensis, 50 parts of Radix Paeoniae Alba, 140 parts of Atractylodes Rhizoma Atractylodes Rhizome, 35 parts of Poria cocos, 120 parts of safflower, saponin thorn 75 parts, 50 parts of bamboo leaf Bupleurum, 145 parts of mint, 80 parts of licorice;

[0049] The preparation method of the safflower Xiaoyao preparation for treating breast cancer comprises the following steps:

[0050] (1) After crushing safflower, licorice, and Bupleurum chinensis, add water to mix and extract, raise the temperature to 75°C for extraction for 1 hour, and then boil for 20 minutes to obtain water extract A and medicinal residue 1;

[0051] Take macroporous adsorption resin chromatography column: the upper layer is AB-8, the middle layer is NKA and the lower layer is NKA-9, wherein the thickness ratio of AB-8, NKA, NKA-9 is 1:1:1 ...

Embodiment 3

[0059] The safflower Xiaoyao preparation for the treatment of breast cancer described in this example includes the following raw materials in parts by weight: 185 parts of Angelica sinensis, 100 parts of Radix Paeoniae Alba, 165 parts of Atractylodes macrocephala, 55 parts of Poria cocos, 60 parts of safflower, and 60 parts of saponins. 40 parts, 20 parts of bamboo leaf Bupleurum, 115 parts of mint, 50 parts of licorice;

[0060] The preparation method of the safflower Xiaoyao preparation for treating breast cancer comprises the following steps:

[0061] (1) After crushing safflower, licorice, and Bupleurum bupleurum, add water to mix and extract, raise the temperature to 90°C for extraction for 2 hours, and then boil for 30 minutes to obtain water extract A and medicinal residue 1;

[0062] Take macroporous adsorption resin chromatography column: the upper layer is AB-8, the middle layer is NKA and the lower layer is NKA-9, wherein the thickness ratio of AB-8, NKA, NKA-9 is 1...

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Abstract

The invention belongs to the field of preparation and application of flos carthami Xiaoyao tablets, and particularly relates to a flos carthami Xiaoyao preparation for treating breast cancer as well as a preparation method and an application of the flos carthami Xiaoyao preparation. The flos carthami Xiaoyao preparation is prepared from raw materials in parts by weight as follows: 18-67 parts of radix angelicae sinensis, 100-150 parts of radix paeoniae alba, 30-55 parts of rhizoma atractylodis macrocephalae, 105-135 parts of poria cocos, 110-160 parts of flos carthami, 20-35 parts of spina gleditsiae, 80-140 parts of herba bupleuri, 45-85 parts of herba menthae and 20-75 parts of radix glycyrrhizae. The drug has a better breast cancer treatment effect, the flos carthami Xiaoyao preparationprepared with the specific method can bring the useful effect of the drug into full play, and besides, the flos carthami Xiaoyao preparation has a good regulating effect on female internal secretion.

Description

technical field [0001] The invention belongs to the field of preparation and application of safflower xiaoyao tablets, and in particular relates to a safflower xiaoyao preparation for treating breast cancer and its preparation method and application. Background technique [0002] The female mammary gland is composed of skin, fibrous tissue, mammary glands and fat. Breast cancer is a malignant tumor that occurs in the mammary gland epithelial tissue. 99% of breast cancers occur in women and only 1% in men. The mammary gland is not an important organ to maintain human life activities, and breast cancer in situ is not fatal; but because breast cancer cells lose the characteristics of normal cells, the connections between cells are loose and easy to fall off. Once the cancer cells fall off, the free cancer cells can spread throughout the body with the blood or lymph fluid, forming metastasis, which is life-threatening. At present, breast cancer has become a common tumor that t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61P35/00A61P35/04
CPCA61K36/076A61K36/232A61K36/233A61K36/284A61K36/286A61K36/483A61K36/484A61K36/534A61K36/65A61K36/71A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P35/00A61P35/04A61K2300/00
Inventor 李小锋刘厚权夏淑英胡吉忠张金良周朝忠毛金娣陈梁
Owner JIANGXI POZIN PHARMA
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