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Medicine composition for treating recurrent respiratory tract infection, and preparation method and application thereof

A composition and technology of the respiratory tract, which are applied to the pharmaceutical composition for treating recurrent respiratory tract infection and the fields of its preparation and use, can solve the problems of unsatisfactory curative effect, large side effects, limited treatment means and the like

Inactive Publication Date: 2019-12-03
四川省中医药科学院中医研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the treatment methods for children with recurrent respiratory tract infection are limited, mainly including etiological treatment, immunomodulator treatment, and traditional Chinese medicine treatment. However, the current treatment methods are expensive, with large side effects and unsatisfactory curative effect.

Method used

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  • Medicine composition for treating recurrent respiratory tract infection, and preparation method and application thereof
  • Medicine composition for treating recurrent respiratory tract infection, and preparation method and application thereof
  • Medicine composition for treating recurrent respiratory tract infection, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1. Preparation of the drug of the present invention

[0025] Formula: 10 grams of Radix Ginseng, 10 grams of Astragalus, 10 grams of Fangfeng, 10 grams of Polygonatum, 10 grams of Atractylodes macrocephala, 15 grams of Polygonum cuspidatum, 15 grams of Radix Isatidis, 10 grams of dried tangerine peel, and 10 grams of Gallus gallus domesticus.

[0026] Preparation:

[0027] Weigh the raw materials according to the formula, add 10 times the amount (w / w, g / g) of water after mixing, decoc 2 times, 1.5h each time, combine the decocting liquid to obtain the medicinal solution, the medicinal solution is at 80℃, pressure -Dry under reduced pressure at 0.080MPa for 6h, then pulverize to a powder with a particle size of less than 80 mesh, add 0.6 times the amount (w / w, g / g) dextrin and 0.2 times the amount (w / w, g / g) stevia mixture Make a soft material with 70% ethanol as a wetting agent to make wet granules, dry for 4 hours at 65°C, and sizing to obtain granules.

Embodiment 2

[0028] Example 2. Preparation of the drug of the present invention

[0029] Formula: 5 grams of Radix Ginseng, 5 grams of Astragalus, 5 grams of Fangfeng, 5 grams of Polygonatum, 5 grams of Atractylodes macrocephala, 7.5 grams of Polygonum cuspidatum, 7.5 grams of Radix Isatidis, 5 grams of dried tangerine peel, 5 grams of Gallus gallus domesticus

[0030] Preparation method: weigh the bulk drug according to the formula, add 5 times the amount (w / w, g / g) of 60% ethanol solution after mixing, reflux 3 times, 1h each time, combine the reflux solution to obtain the drug solution, the drug solution is at a temperature of 85 Under the conditions of ℃ and pressure -0.060MPa, it is concentrated under reduced pressure to a clear paste with a relative density of 1.08~1.12, then spray-dried at a temperature of 160~180℃ and an air outlet temperature of 80~100℃, dry granulated, and filled into capsules. Capsules.

Embodiment 3

[0031] Example 3. Preparation of the drug of the present invention

[0032] Formula: 30 grams of Radix Ginseng, 30 grams of Astragalus, 30 grams of Fangfeng, 30 grams of Polygonatum, 30 grams of Atractylodes macrocephala, 45 grams of Polygonum cuspidatum, 45 grams of Radix Isatidis, 30 grams of dried tangerine peel, 30 grams of Gallus gallus domesticus.

[0033] Preparation method: weigh the bulk drug according to the formula, add 8 times the amount (w / w, g / g) 70% ethanol solution after mixing, reflux for 2 times, 1.5h each time, combine the reflux liquid to obtain the medicinal solution. Dry under reduced pressure at 75°C and pressure -0.080MPa for 8 hours, then pulverize to a powder with a particle size of less than 80 mesh, add 0.4 times the amount (w / w, g / g) of dextrin, and use 70% ethanol as a wetting agent. Prepare soft materials, prepare wet granules, dry at 80°C for 4 hours, sizing, compressing, and coating to obtain tablets.

[0034] The following test examples illustrate t...

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Abstract

The invention discloses a medicine composition for treating recurrent respiratory tract infection. The medicine composition is prepared from the following raw materials in parts by weight: 5-30 partsof pseudostellariae radix, 5-30 parts of radix astragali, 5-30 parts of radix saposhnikoviae, 5-30 parts of polygonati rhizome, 5-30 parts of atrctylodis macrocephalae rhizome, 5-45 parts of rhizoma polygoni cuspidate, 5-45 parts of isatidis radix, 5-30 parts of pericarpium citri reticulatae and 5-30 parts of endothelium corneum gigeriae galli. The medicine composition is an oral preparation, hasefficacies on tonifying the lung, tonifying the spleen and benefiting qi, has an obvious regulation function for the immunologic functions of child patients who suffer from the recurrent respiratory tract infection, and is suitable for clinic promotion and use.

Description

Technical field [0001] The invention specifically relates to a pharmaceutical composition for treating repeated respiratory infections, and a preparation method and application thereof. Background technique [0002] Recurrent respiratory infection is a common disease in pediatrics, with an incidence rate of about 20%. It specifically refers to the respiratory tract infections with frequent upper respiratory tract infections or lower respiratory tract infections that exceed a certain range within one year. Different age diagnostic criteria are different, repeated upper respiratory tract infections are more than 7 times per year for infants and children under 2 years old, more than 6 times per year for children aged 3 to 5 years old, and more than 5 times per year for children over 6 years old; repeated lower respiratory tract infections are under 2 years old Infants and young children more than 3 times / year, 3 to 5 years old children more than 2 times / year, and children over 6 ye...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P11/00A61P31/00A61P37/02A61K35/57
CPCA61K35/57A61K36/195A61K36/238A61K36/284A61K36/315A61K36/36A61K36/481A61K36/704A61K36/752A61K36/8969A61K2236/331A61K2236/39A61K2236/51A61P11/00A61P31/00A61P37/02A61K2300/00
Inventor 李玲冯建安勾宗惠陈东辉
Owner 四川省中医药科学院中医研究所
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