Application of atractylenolide II for preparing medicine capable of improving insulin resistance and glucose-lipid metabolism disorder caused by obesity

A technique of atractylide and its use, applied in the field of medicine, can solve the problems that have not yet been seen.

Inactive Publication Date: 2019-12-10
CHINA PHARM UNIV
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  • Abstract
  • Description
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Problems solved by technology

[0004] At present, there is no application of Atractylolide II to improve insulin resistance and glucose and lipid metabolism disorders caused by obesity

Method used

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  • Application of atractylenolide II for preparing medicine capable of improving insulin resistance and glucose-lipid metabolism disorder caused by obesity
  • Application of atractylenolide II for preparing medicine capable of improving insulin resistance and glucose-lipid metabolism disorder caused by obesity
  • Application of atractylenolide II for preparing medicine capable of improving insulin resistance and glucose-lipid metabolism disorder caused by obesity

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Embodiment Construction

[0024] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0025] 1. Reagents and materials

[0026] C57BL / 6J mice, 6-7 weeks old, male, SPF grade. Purchased from SPEF (Beijing) Biotechnology Co., Ltd. (licence: SCXK (Beijing) 2016-0002), quality inspection unit: Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. testing room, animal experiment unit: China Pharmaceutical University , NO.1103241911003587, experimental unit license number: SYXK (Su) 2016-0011.

[0027] Atractylenolide II (2-Atractylenolide) was purchased from Chengdu Master Biotechnology Co., Ltd., product number: A0373-3g, batch number: MUST-19030202, CAS NO: 73069-14-4, MF: C15H20O2, MW: 232.32Purity : 99.99% (HPLC).

[0028] Metformin (Metformin Hydrochloride) was purchased from MedChemExpress, product number: HY-17471A / CS-1851, CAS NO: 1115-70-4, ...

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Abstract

The invention discloses application of atractylenolide II for preparing a medicine capable of improving insulin resistance and glucose-lipid metabolism disorder caused by obesity. After mice are fed in a high fat mode, the weights of the mice are increased, and respiratory quotient and energy consumption are obviously reduced, and thus, fat mice mainly take lipid metabolism as a main part insteadof glucose metabolism as the main part, fat tissues are pathologically changed and lipid droplets are increased, and meanwhile, some index detection of blood plasma and liver also proves diseases of liver damage and insulin resistance of the mice. Based on the application of the atractylenolide II disclosed by the invention, after the atractylenolide II is provided for treatment, the weights and the glucose-lipid metabolism of the fat mice are improved, the lipid droplets of the livers are reduced, and the insulin resistance is recovered. Therefore, because of the atractylenolide II, the insulin resistance and the glucose-lipid metabolism disorder caused by the obesity can be effectively improved.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the new application of known compounds, in particular to the application of atractyloid II for the preparation of medicines for improving insulin resistance and glucose and lipid metabolism disorders caused by obesity. Background technique [0002] Obesity is caused by excessive energy intake, which significantly exceeds energy consumption, resulting in lipid metabolism disorder. Lipid disorder can reduce insulin sensitivity and cause insulin resistance. In the pathological process of obesity-induced insulin resistance, high expression of lipase (LPL) was found in the liver of liver-specific insulin-resistant lipid accumulation mice. In recent years, studies have shown that diacylglycerols (DAGs) or ceramides ( Ceramides) are the material basis of insulin resistance. In an obese type II prediabetic model, mainly liver tissue DAGs mediate the insulin resistance induced by lipid accumulation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P5/50A61P3/00A61P1/16
CPCA61K31/365A61P5/50A61P3/00A61P1/16
Inventor 李萍杨华郑祖国徐殷越张晓雨
Owner CHINA PHARM UNIV
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