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Traditional Chinese medicine composition and application thereof in preparing drugs for treating rhinitis

A technology of composition and traditional Chinese medicine, applied in the direction of drug combination, pharmaceutical formula, plant raw material, etc.

Active Publication Date: 2019-12-10
北京博奥晶方生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Rhinitis is an inflammatory disease of the nasal cavity. It is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. Common classifications include acute rhinitis, chronic rhinitis, and allergic rhinitis. Rhinitis belongs to A frequently-occurring disease for which there is currently no better treatment

Method used

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  • Traditional Chinese medicine composition and application thereof in preparing drugs for treating rhinitis
  • Traditional Chinese medicine composition and application thereof in preparing drugs for treating rhinitis
  • Traditional Chinese medicine composition and application thereof in preparing drugs for treating rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take magnolia 10g, ligusticum 10g, mulberry leaves 10g, licorice 10g, and purslane 15g.

[0035] Grind magnolia, ligusticum, mulberry leaves, licorice, and purslane into 80-100 mesh powders according to the formula, weigh them according to the proportion and mix them, weigh 10g of the mixed powder, add 15 times the volume of 90% ethanol aqueous solution 150mL, standard Soxhlet heating and reflux extraction for 3 hours, the extract was heated and concentrated for 20 minutes to a volume of 2 mL, transferred to a lyophilizer at a temperature of -60 ° C, and lyophilized under reduced pressure for 24 hours under a vacuum of 0.08 kpa to make an extract lyophilized powder, and weighed a certain amount Freeze-dried powder, dissolved in dimethyl sulfoxide (DMSO) to prepare the extract mother solution with a concentration of 100mg / mL, and stored at 4°C.

[0036] Efficacy verification

[0037] 1. Using qPCR technology, it was discovered that the extracts of traditional Chinese me...

Embodiment 2

[0072] The present embodiment is basically the same as Example 1, except that the proportioning of each Chinese medicine component is different, which is as follows: 5 parts by mass of Magnolia magnolia, 5 parts by mass of Ligusticum edulis, 5 parts by mass of mulberry leaves, 5 parts by mass of licorice and 5 parts by purslane. parts by mass.

[0073] Efficacy verification as described in Example 1 was also carried out, and the result was similar to that of Example 1.

Embodiment 3

[0075] The present embodiment is basically the same as Example 1, except that the proportioning of each Chinese medicine component is different, as follows: 30 mass parts of magnolia magnolia, 30 mass parts of Ligusticum edulis, 20 mass parts of mulberry leaves, 20 mass parts of licorice and 30 parts of purslane. parts by mass.

[0076] Efficacy verification as described in Example 1 was also carried out, and the result was similar to that of Example 1.

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Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and application thereof in preparing drugs for treating rhinitis. The traditional Chinese medicine composition provided by the present invention comprises flower buds of lily magnolia, ligusticum, mulberry leaves, liquorice roots and purslane, each medicine material is compounded according to a certain proportion, and the composition can significantly inhibit the expression of key inflammatory factors IL-6 and IL-1 beta, and inhibit the content of vascular endothelial relaxing factor nitric oxide. Therefore, the composition has the function of treating rhinitis or assisting in treating rhinitis. According to the present invention, the main functions of the traditional Chinese medicine composition are: dispersing, dissipating cold, and clearing noses, and the composition is suitable for rhinitis and allergic rhinitis, of which the clinical manifestations are continuous sneezing, nasal itching, nasal obstruction, runny nose, etc. caused by encountering pollen or dust mite, cold air, etc.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and its application in preparing medicines for treating rhinitis. Background technique [0002] Rhinitis is an inflammatory disease of the nasal cavity. It is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. Common classifications include acute rhinitis, chronic rhinitis, and allergic rhinitis. Rhinitis belongs to It is a frequently-occurring disease for which there is currently no better treatment. [0003] When rhinitis occurs, the levels of various inflammatory cytokines in the serum of patients increase. Inflammatory cytokines refer to various cytokines involved in inflammatory reactions. Common inflammatory cytokines include interleukin 1 (IL-1), interleukin 6 (IL-6), etc. They are cytokines that mainly affect the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61P11/02
CPCA61K36/575A61K36/236A61K36/605A61K36/484A61K36/185A61P11/02A61K2300/00
Inventor 谢兰党红蕾黄文婷张晓玲郭弘妍邢婉丽程京
Owner 北京博奥晶方生物科技有限公司
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