Traditional Chinese medicine composition and application thereof in preparing drugs for treating rhinitis
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of composition and traditional Chinese medicine, applied in the direction of drug combination, pharmaceutical formula, plant raw material, etc.
Active Publication Date: 2019-12-10
北京博奥晶方生物科技有限公司
View PDF2 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0002] Rhinitis is an inflammatory disease of the nasal cavity. It is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. Common classifications include acute rhinitis, chronic rhinitis, and allergic rhinitis. Rhinitis belongs to A frequently-occurring disease for which there is currently no better treatment
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0034] Take magnolia 10g, ligusticum 10g, mulberry leaves 10g, licorice 10g, and purslane 15g.
[0035] Grind magnolia, ligusticum, mulberry leaves, licorice, and purslane into 80-100 mesh powders according to the formula, weigh them according to the proportion and mix them, weigh 10g of the mixed powder, add 15 times the volume of 90% ethanol aqueous solution 150mL, standard Soxhlet heating and reflux extraction for 3 hours, the extract was heated and concentrated for 20 minutes to a volume of 2 mL, transferred to a lyophilizer at a temperature of -60 ° C, and lyophilized under reduced pressure for 24 hours under a vacuum of 0.08 kpa to make an extract lyophilized powder, and weighed a certain amount Freeze-dried powder, dissolved in dimethyl sulfoxide (DMSO) to prepare the extract mother solution with a concentration of 100mg / mL, and stored at 4°C.
[0036] Efficacy verification
[0037] 1. Using qPCR technology, it was discovered that the extracts of traditional Chinese me...
Embodiment 2
[0072] The present embodiment is basically the same as Example 1, except that the proportioning of each Chinese medicine component is different, which is as follows: 5 parts by mass of Magnolia magnolia, 5 parts by mass of Ligusticum edulis, 5 parts by mass of mulberry leaves, 5 parts by mass of licorice and 5 parts by purslane. parts by mass.
[0073] Efficacy verification as described in Example 1 was also carried out, and the result was similar to that of Example 1.
Embodiment 3
[0075] The present embodiment is basically the same as Example 1, except that the proportioning of each Chinese medicine component is different, as follows: 30 mass parts of magnolia magnolia, 30 mass parts of Ligusticum edulis, 20 mass parts of mulberry leaves, 20 mass parts of licorice and 30 parts of purslane. parts by mass.
[0076] Efficacy verification as described in Example 1 was also carried out, and the result was similar to that of Example 1.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and application thereof in preparing drugs for treating rhinitis. The traditional Chinese medicine composition provided by the present invention comprises flower buds of lily magnolia, ligusticum, mulberry leaves, liquorice roots and purslane, each medicine material is compounded according to a certain proportion, and the composition can significantly inhibit the expression of key inflammatory factors IL-6 and IL-1 beta, and inhibit the content of vascular endothelial relaxing factor nitric oxide. Therefore, the composition has the function of treating rhinitis or assisting in treating rhinitis. According to the present invention, the main functions of the traditional Chinese medicine composition are: dispersing, dissipating cold, and clearing noses, and the composition is suitable for rhinitis and allergic rhinitis, of which the clinical manifestations are continuous sneezing, nasal itching, nasal obstruction, runny nose, etc. caused by encountering pollen or dust mite, cold air, etc.
Description
technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and its application in preparing medicines for treating rhinitis. Background technique [0002] Rhinitis is an inflammatory disease of the nasal cavity. It is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. Common classifications include acute rhinitis, chronic rhinitis, and allergic rhinitis. Rhinitis belongs to It is a frequently-occurring disease for which there is currently no better treatment. [0003] When rhinitis occurs, the levels of various inflammatory cytokines in the serum of patients increase. Inflammatory cytokines refer to various cytokines involved in inflammatory reactions. Common inflammatory cytokines include interleukin 1 (IL-1), interleukin 6 (IL-6), etc. They are cytokines that mainly affect the...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more