Medical adhesive
A technology of adhesives and water-based solvents, used in surgical adhesives, applications, medical science, etc.
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[0027] In addition, such as figure 1 As shown, the present invention discloses a preparation method of the aforementioned medical adhesive, which includes the following steps: step 1 obtains mucus from the skin of living giant salamander, and freeze-drys the mucus; step 2 crushes the freeze-dried mucus by cryoball milling to form giant salamander skin Mucus freeze-dried powder; step 3 uses ethylene oxide to sterilize the giant salamander skin mucus freeze-dried powder; and step 4, the sterilized giant salamander skin mucus freeze-dried powder and the aqueous solvent are based on the weight of 1:1 to 1:6 The mixing ratio (hereinafter referred to as the powder-water ratio) is mixed to form a hydrogel.
[0028] The method of collecting mucus in the step 1 should be carried out strictly in accordance with China's animal protection law, without killing the giant salamander nor causing permanent disability of the giant salamander.
[0029] Step 3 is about the sterilization and disinfecti...
Embodiment 1
[0032] [Example 1] Structural analysis of the hydrogel of the present invention
[0033] A scanning electron microscope (Hitachi, S-3400N II, Japan) was used to analyze the porous structure of the hydrogel according to the present invention, such as Figure 2A Shown. The lyophilized powder of the giant salamander skin mucus formed by freeze-drying the giant salamander skin mucus is a white powder, which is shown as uneven lumps by scanning electron microscope analysis. However, when the lyophilized powder of giant salamander skin mucus is mixed with an aqueous solvent, the polypeptide chains in the agglomerate will swell and penetrate each other to form a high-water gel with a three-dimensional honeycomb structure. As the gelation time increases, the porous structure becomes more obvious and the pore size becomes more uniform; in addition, from Figure 2A It can be further learned that in the pore structure after 12 hours of gelation, the density of the sidewall of the holes incr...
Embodiment 2
[0034] [Example 2] Analysis of hydrogel swelling rate
[0035] Because surgical wounds and wounds are usually located at the interface between the body surface and the outside, and at the same time face the external temperature change and the constant temperature of human tissue at about 37°C, good performance is required in terms of swelling rate.
[0036] According to the present invention, a hydrogel is proposed. When the lyophilized skin mucus powder of giant salamander is mixed with an aqueous solvent, the polypeptide cross-linking network swells rather than dissolves. After mixing, the entangled protein network driven by hydrogen bonds of the lyophilized skin mucus powder of giant salamander will be changed to form Gel, this process is called swelling. During the swelling process, the amino acid residues of the polypeptide chain undergo a conformational transformation to form a gel-like adhesive. The phenolic hydroxyl and amino groups are used as hydrogen bond donors to trans...
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Abstract
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