Sulfydryl-containing modified blood purification membrane and preparation method thereof

A technology of blood purification and thiolization, which is applied in the field of medicine, can solve the problems of blood vessel wall damage, aggravated risk of dialysis membrane incompatibility, prone to complicated lipid metabolism disorders and cardiovascular diseases, etc., and achieves a simple procedure suitable for popularization and application Effect
CN110652891AActive Publication Date: 2020-01-07XIANGYA HOSPITAL CENT SOUTH UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XIANGYA HOSPITAL CENT SOUTH UNIV
Publication Date
2020-01-07

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Abstract

The invention belongs to the technical field of medicines, and relates to a preparation method of a sulfydryl-containing modified blood purification membrane. The preparation method comprises the following steps: 1) preparation of aminated polyether sulfone, 2) preparation of sulfydryl polyether sulfone, and 3) preparation of a sulfydryl polyether sulfone membrane. The invention also discloses thesulfydryl-containing modified blood purification membrane prepared by the preparation method. The sulfydryl-containing modified blood purification membrane has the advantages of improvement of the oxidation resistance of a dialysis membrane, protection of leucocytes, reduction of the vascular permeability, simple preparation method, and realization of industrial batch production.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a modified blood purification membrane containing mercapto groups and a preparation method thereof. Background technique

[0002] Blood purification therapy (hemodialysis and hemofiltration, etc.) is widely used in acute and chronic renal insufficiency, severe pancreatitis, multiple organ failure and other critically ill patients, especially patients with chronic kidney disease need long-term blood purification therapy . Although the above-mentioned treatments can replace part of the function of the kidneys and promote the excretion of toxic substances in the body, patients are prone to lipid metabolism disorders and cardiovascular diseases. The most important reason for this is the damage to the vessel wall by oxidative stress and micro-inflammatory state. The risk is further aggravated by the patient's own oxidative stress due to the disease state, and the incompa...

Claims

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