Astragalus membranaceus-paecilomyces cicadae fermented fungal substance, preparation method and application

A technology of Paecilomyces cicadae and fermentation bacteria, which is applied in the field of preparation and fermentation of traditional Chinese medicine Astragalus-Paecilomyces cicadae, which can solve the problems that it is difficult to ensure the safety, effectiveness, stability and controllability of fermented Chinese medicine products, and achieve the impact of drug efficacy Significant, yield-enhancing, effect-enhancing effects

Active Publication Date: 2020-01-07
BINZHOU MEDICAL COLLEGE
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  • Abstract
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Problems solved by technology

Since the types and quantities of bacteria involved in the fermentation of traditional Chinese medicine are affected by geographical environment and seasonal changes, and the fermentation process i

Method used

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  • Astragalus membranaceus-paecilomyces cicadae fermented fungal substance, preparation method and application
  • Astragalus membranaceus-paecilomyces cicadae fermented fungal substance, preparation method and application
  • Astragalus membranaceus-paecilomyces cicadae fermented fungal substance, preparation method and application

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preparation example Construction

[0032] A preparation method for astragalus-Paecilomyces cicadae fermentation bacterial mass, comprising the steps of:

[0033] (1) The preparation steps of Astragalus enzymatic hydrolyzate: mix Astragalus medicinal material with water, add cellulase and pectinase to carry out enzymolysis, sterilize, cool, and obtain Astragalus enzymolyzate;

[0034] (2) Fermentation step: inoculate Paecilomyces cicadae into the astragalus enzymatic hydrolyzate, and culture in liquid to obtain Paecilomyces cicadae-Astragalus fermented bacterial mass.

[0035] In step (1), the Astragalus medicinal material is preferably used in the form of Astragalus medicinal material powder. According to a preferred embodiment of the present invention, the particle size of the Astragalus medicinal material powder is 60-120 mesh sieve, preferably 80-120 mesh sieve, more preferably 100 mesh sieve. Adopting the particle size of the astragalus medicinal material powder is beneficial to the enzymatic hydrolysis of...

Embodiment 1

[0056] The Radix Astragali medicinal material is pulverized and passed through a 100-mesh sieve to obtain the medicinal material Radix Astragali powder. Mix the astragalus medicinal material powder with 5 times the amount (weight) of distilled water of the medicinal material powder, add successively the cellulase of 1.5wt% of the weight of the astragalus medicinal material powder and the pectinase of 1.5wt% of the weight of the astragalus medicinal material powder, and enzyme at 50°C Decompose for 90 minutes, place it in a steam sterilizer at 121° C. for sterilizing for 30 minutes, and cool to room temperature to obtain an enzymatic solution of Astragalus; inoculate Paecilomyces cicadae into the enzymatic solution of Astragalus, and the inoculum amount is 10wt% of the weight of Astragalus medicinal material. 28℃, 120r·min -1 Cultivate for 7 days under shaking table conditions to obtain Paecilomyces cicadae-Astragalus fermentation bacterial mass A (hereinafter referred to as "b...

Embodiment 2

[0058] The Radix Astragali medicinal material is pulverized and passed through a 100-mesh sieve to obtain the medicinal material Radix Astragali powder. Mix the astragalus medicinal material powder with 5 times the amount (weight) of distilled water of the medicinal material powder, add successively the cellulase of 1.5wt% of the weight of the astragalus medicinal material powder and the pectinase of 1.5wt% of the weight of the astragalus medicinal material powder, and enzyme at 50°C Decompose for 90 minutes, sterilize in a steam sterilizer at 121°C for 30 minutes, cool to room temperature, and obtain astragalus enzymolysis liquid; 10wt% of medicinal material weight, seed solution inoculation amount is 4vol%, at 28 ℃, 120r min -1 Cultivate for 7 days under shaking table conditions to obtain Paecilomyces cicadae-Astragalus fermentation bacterial mass B (hereinafter referred to as "bacterial mass B").

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Abstract

The invention discloses astragalus membranaceus-paecilomyces cicadae fermented fungal substance and a preparation method and application thereof. The fermented fungal substance is prepared by liquid fermentation by taking an enzymatic hydrolysate of astragalus membranaceus as a fermentation substrate and paecilomyces cicadae as a fermentation strain; wherein the enzymatic hydrolysate of astragalusmembranaceus is obtained by enzymatic hydrolysis of astragalus membranaceus through cellulase and pectinase. The astragalus membranaceus-paecilomyces cicadae fermented fungal substance has significantly increased astragalus polysaccharide content, and has significant effects in treating hyperuricemia and / or hypertriglyceridemia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine fermentation fungus, a preparation method and an application, in particular to a traditional Chinese medicine astragalus-Paecilomyces cicada fermentation fungus, a preparation method and an application. Background technique [0002] Fermentation of traditional Chinese medicine is to use the action of enzymes and microorganisms, under certain environmental conditions (such as temperature, humidity, air, moisture, etc.), to make the medicine change its original performance, enhance or produce new efficacy through the fermentation process, and expand the variety of medicines. , to meet the needs of clinical medication. [0003] Traditional Chinese medicine fermentation is a microbial fermentation technology, which refers to the method that after the medicine is purified or treated, under certain temperature and humidity conditions, the medicine is catalyzed and decomposed by microorganisms and enzyme...

Claims

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Application Information

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IPC IPC(8): C12P1/02A61K36/481A61P19/06A61P3/06C12R1/645
CPCA61K36/068A61K36/481A61P3/06A61P19/06C12P1/02C12N1/145C12R2001/645A61K2300/00
Inventor 张加余代龙王少平耿子凯王喻淇刘子菡
Owner BINZHOU MEDICAL COLLEGE
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