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Bacterium resisting anticoagulant ventriculoperitoneal branch pipe silicone pipe body and preparation method and application thereof

A technology of shunt tubes and silicone tubes, applied in catheters and other directions, can solve the problem of anticoagulant coating easy to fall off, etc.

Inactive Publication Date: 2020-01-17
JIANGSU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the technical problems in the prior art that the antibacterial and anticoagulant coatings are easy to fall off and have poor effects, an antibacterial and anticoagulant ventricular-peritoneal shunt tube silicone tube body and its preparation method and application are provided

Method used

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  • Bacterium resisting anticoagulant ventriculoperitoneal branch pipe silicone pipe body and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1), an antibacterial and anticoagulant ventriculoperitoneal shunt tube silicone tube body, which is prepared from component A and component B according to the weight ratio of 1:0.9, wherein,

[0029] Component A includes the following components in parts by weight: 100 parts of vinyl-containing dimethylsiloxane, 3 parts of barium sulfate, 0.4 part of antibacterial agent, 0.5 part of anticoagulant, and 0.6 part of dispersant;

[0030] Component B includes the following components in parts by weight: 90 parts of dimethylsiloxane containing active hydrogen and platinum catalyst.

[0031] The vinyl content in the vinyl-containing dimethylsiloxane is 0.4 wt%.

[0032] The content of active hydrogen in the dimethylsiloxane containing active hydrogen and platinum catalyst is 0.08wt%, and the content of platinum catalyst is 0.7wt%.

[0033] The antibacterial agent is thiopeptidemycin.

[0034] The anticoagulant is hirudin.

[0035] The dispersant is polyethylene glycol.

...

Embodiment 2

[0045] (1), an antibacterial and anticoagulant ventriculoperitoneal shunt tube silicone tube body, which is prepared from component A and component B according to the weight ratio of 1:1, wherein,

[0046] Component A includes the following components in parts by weight: 100 parts of vinyl-containing dimethylsiloxane, 7 parts of barium sulfate, 3.5 parts of antibacterial agent, 3 parts of anticoagulant, and 2.2 parts of dispersant;

[0047] Component B includes the following components in parts by weight: 100 parts of dimethylsiloxane containing active hydrogen and platinum catalyst.

[0048] The vinyl content in the vinyl-containing dimethylsiloxane is 0.55 wt%.

[0049] The content of active hydrogen in the dimethylsiloxane containing active hydrogen and platinum catalyst is 0.24wt%, and the content of platinum catalyst is 0.6wt%.

[0050] The antibacterial agent is spiramycin.

[0051] The anticoagulant is acetylsalicylic acid and chitosan, and the mass ratio of the two i...

Embodiment 3

[0060] (1), an antibacterial and anticoagulant ventriculoperitoneal shunt tube silicone tube body, which is prepared from component A and component B according to the weight ratio of 1:1, wherein,

[0061] Component A includes the following components in parts by weight: 110 parts of vinyl-containing dimethylsiloxane, 2.5 parts of barium sulfate, 5.0 parts of antibacterial agent, 2 parts of anticoagulant, and 1.8 parts of dispersant;

[0062] Component B includes the following components in parts by weight: 120 parts of dimethylsiloxane containing active hydrogen and platinum catalyst.

[0063] The vinyl content in the vinyl-containing dimethylsiloxane is 0.47wt%.

[0064] The content of active hydrogen in the dimethylsiloxane containing active hydrogen and platinum catalyst is 0.24wt%, and the content of platinum catalyst is 0.17wt%.

[0065] The antibacterial agent is a mixture of lasalonomycin and olaquindox, and the mass ratio of the two is 3:7.

[0066] The anticoagulan...

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Abstract

The invention relates to a bacterium resisting anticoagulant ventriculoperitoneal branch pipe silicone pipe body and a preparation method and application thereof. The branch pipe silicone pipe body isprepared from an A component and a B component in the weight ratio of 1:(0.7-1.3), wherein the A component comprises the following components in parts by weight of 100-120 parts of vinyl-containing dimethyl silicone, 0.05-10 parts of barium sulfate, 0.05-15 parts of an antibacterial agent, 0.05-15 parts of an anticoagulant and 0.5-15 parts of a dispersing agent, and the B component comprises thefollowing components in parts by weight of 70-130 parts of active hydrogen and platinum gold catalyst containing dimethyl silicone. Through extruding, curing and shaping, the bacterium resisting anticoagulant ventriculoperitoneal branch pipe silicone pipe body is obtained. The material has permanent bacterium resistance, has good bacterium resistance and long recalcification time, time for activating part of blood coagulation live enzymes, and prothrombin time.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to an antibacterial and anticoagulant ventriculoperitoneal shunt tube silicone tube body and a preparation method and application thereof. Background technique [0002] Since Pudenz used a shunt system made of silicone resin to treat hydrocephalus in 1955, the shunt tube made of silicone has been used up to now because of its softness, elasticity, and not easy to break. One end of the silicone tube body of the shunt tube is placed into the ventricle, and the other end extends downward through the subcutaneous tunnel to the abdominal cavity or other parts to drain the cerebrospinal fluid in the ventricle to restore the balance between secretion and absorption of cerebrospinal fluid, so as to achieve the treatment of hydrocephalus the goal of. However, with its widespread use, the shortcomings of this type of shunt tube silicone tube body are gradually exposed, such as not ...

Claims

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Application Information

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IPC IPC(8): A61L29/06A61L29/16A61L29/14A61L29/02A61L29/18
CPCA61L29/02A61L29/06A61L29/14A61L29/16A61L29/18C08L83/04
Inventor 向萌董爽向勇钟奇钟阳谦杨琼梅杨洲陈建香
Owner JIANGSU UNIV OF TECH
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