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Epstein-Barr (EB) virus related antigen short peptide and application thereof

A technology of Epstein-Barr virus and short peptides, which is applied in the direction of virus antigen components, virus peptides, viruses, etc., can solve the problems of weak immunity and long-lasting immunity, and achieve the effects of preventing re-infection, reducing application costs, and increasing the activity of DC cells

Pending Publication Date: 2020-01-17
维塔恩(广州)医药有限公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

But its immunity is often not long-lasting and not strong

Method used

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  • Epstein-Barr (EB) virus related antigen short peptide and application thereof
  • Epstein-Barr (EB) virus related antigen short peptide and application thereof
  • Epstein-Barr (EB) virus related antigen short peptide and application thereof

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Embodiment 1

[0043]Dendritic Cell therapy technology (Dendritic Cell, DC) is to collect autologous peripheral blood mononuclear cells, add specific cytokines in a strict aseptic environment, and at the same time supplement with stem cell factor / vitrogen factor to obtain more active transformed cells. Dendritic cell (DC) with antigen presenting function. Epstein-Barr virus antigen peptides were added the day before reinfusion, and DCs recognized and captured a variety of single-epitope antigen peptides to obtain mature dendritic cells sensitized by specific antigen peptides of high-risk pathogenic viruses, using the ability of dendritic cells to target migration and immune activity, which can induce the body to produce a large number of antibodies against specific antigens, and then rebuild the immune balance of the body, so that by preventing and controlling pathogenic virus infection, the prevention of pathogenic microorganisms is more directional and active, and fundamentally prevents EB ...

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Abstract

The invention discloses an Epstein-Barr (EB) virus related antigen short peptide and application thereof. The sequence of the EB virus related antigen short peptide is shown as any of SEQ ID NO:1-16;the short peptide has high affinity with MHC I-type and MHC II-type molecules on dendritic cells (DC), can effectively achieve the antigen presentation effect and has the good potential of a polypeptide vaccine and a DC vaccine; the DC vaccine prepared from the one or more in-vitro sensitized DCs in the short peptide can prevent EB virus related diseases, and thus the good clinical transformationprospects are achieved; and the antigen short peptide is small in length and small in chemical synthesis difficulty and can be directly synthesized to obtain a high-purity product, the application cost is lowered greatly, meanwhile the effect is clear, and the antigen short peptide has great application prospects.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to Epstein-Barr virus-related antigen short peptides and applications thereof. Background technique [0002] Epstein-Barr virus (EBV) is a member of the herpesviridae lymphotropic virus genus and is a pathogen of infectious mononucleosis, which specifically infects humans and some primates in vitro and in vivo. B-cell-like biological characteristics, mainly spread through saliva. EBV is similar to other herpes viruses under the electron microscope, but the antigenicity is different. The EBV genome is about 172KB and can encode at least more than 100 proteins. B cells are the main target cells for infection. After entering the human body, they can directly enter the latent state. It is characterized by , viral persistence, limited viral protein expression, and the potential to be primed into the replication cycle. [0003] Epstein-Barr virus is closely related ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/05A61K39/245A61P31/22
CPCA61K39/12A61K2039/5154A61P31/22C07K14/005C12N2710/16222C12N2710/16234
Inventor 黄燕花赵乙木罗夫·辛克纳吉孙晨
Owner 维塔恩(广州)医药有限公司
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