Use of a compound in medicine

A compound and compound structure technology, applied in the field of natural product chemistry, can solve the problem of less anticoagulant active ingredients, and achieve the effects of good biological activity, high purity and good stability

Active Publication Date: 2022-07-19
FUJIAN SANAN SINO SCI PHOTOBIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to reports, the research on this medicinal material mainly focuses on the procoagulant or hemostatic effect of this medicinal material, and there are few studies on the anticoagulant active ingredients in this medicinal material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A preparation method of a compound, comprising the steps:

[0056] Source of materials: Feng Lun Cai was purchased from Luyuan Biotechnology Co., Ltd., and the specimens of this medicinal material were kept in the Pharmacy Office of the Drug Research and Development Center of Fujian Zhongke Biotechnology Co., Ltd.

[0057] (1) take the aerial part of the fenugreek as raw material, dry, and after pulverizing the obtained coarse powder 10kg, the coarse powder is extracted with 100L, 60% aqueous ethanol solution, and the gained extract is rotary evaporated to dryness to obtain the crude extract extract 980g;

[0058] (2) After using an appropriate amount of pure water to dissolve the extract to prepare an aqueous solution with a concentration of 50 mg / mL, use chloroform and n-butanol to extract respectively, specifically according to the ratio of organic phase: water phase=4:1 (v / v) extraction, After oscillating at an amplitude of 120 rpm for 15 minutes, let stand for 4 ho...

Embodiment 2

[0067] A preparation method of a compound, comprising the steps:

[0068] (1) take the aerial part of broken blood (Ceratophytum) as raw material, pulverize the dry sample to obtain 5kg, then extract with 50L, 60% methanol aqueous solution, and the obtained extract is rotary evaporated to dryness to obtain 480g of crude extract extract;

[0069] (2) Take 450g of crude extract extract and use pure water to prepare an aqueous solution with a concentration of 100mg / mL, and then use chloroform and n-butanol to extract respectively, specifically according to the organic phase: water phase=4:1 (v / v) ratio Extraction was carried out by using a vibrator with an amplitude of 120rpm for 15min and then standing for 4 hours, and extracted three times in total to obtain 145g of n-butanol extract;

[0070] (3) Take 130 g of n-butanol extract, use D101 macroporous adsorption resin column chromatography, and sequentially use 0%, 20%, 45%, 70%, 100% (v / v) ethanol / water solution as the eluent t...

Embodiment 3

[0075] A preparation method of a compound, comprising the steps:

[0076] (1) Using the aerial part of the blood-breaking medicinal material (Ceratophytum) as the raw material, the dried sample was pulverized to obtain 5kg of coarse powder, extracted with a 70% ethanol aqueous solution, and the obtained extract was rotary evaporated to dryness to obtain 430g of crude extract extract;

[0077] (2) Take 410g of crude extract extract and use pure water to prepare an aqueous solution with a concentration of 100mg / mL, then use chloroform and n-butanol to extract respectively, specifically according to the organic phase: water phase=4:1 (v / v) Proportional extraction, vibrating with an amplitude of 120 rpm for 15 min and then standing for 4 hours, extracting three times in total to obtain 135 g of n-butanol extract;

[0078] (3) Take 125g of n-butanol extract, use D101 macroporous adsorption resin column chromatography, and use 0%, 30%, 60%, 85%, 100% (v / v) ethanol / water solution as ...

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Abstract

The invention discloses a compound, its preparation method and application. The molecular formula of the compound is C 27 H 22 O 10 , the molecular weight is 506. The compound obtained by the preparation method of the present invention has high purity, 98% purity, good stability and good biological activity. Through the method of in vitro coagulation activity test, it is found that the compound has a strong inhibitory activity on platelet aggregation activated by thrombin, and has the potential to develop anticoagulant or antithrombotic drugs and medical equipment.

Description

technical field [0001] The invention belongs to the technical field of natural product chemistry, and in particular relates to a compound isolated from C. chinensis, a preparation method and medical use thereof, and the molecular formula of the compound is C 27 H 22 O 10 , the molecular weight is 506. Background technique [0002] Labiatae belongs to the genus Clinopodium Linn. There are more than 20 species of plants in the world, mainly distributed in Europe, Central Asia and eastern Asia. Feng Lun Cai and Yin Feng Lun were included in the 2010 edition of the "Chinese Pharmacopoeia" as medicinal for breaking blood flow. They have the effect of astringent and hemostasis. They are mainly used for the treatment of uterine bleeding, hematuria, epistaxis, bleeding gums, traumatic bleeding and other bleeding and Purpura simplex, idiopathic thrombocytopenic purpura embolism. my country is rich in medicinal plant resources and has a long history of medicinal use in the folk, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P7/02A61P9/00C07D307/86
CPCA61K31/343A61P7/02A61P9/00C07D307/86
Inventor 占卓雷绍南单世斌张靖王佩忠
Owner FUJIAN SANAN SINO SCI PHOTOBIOTECH CO LTD
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