3 results about "Increased Coagulation Activity" patented technology

The present invention relates to a novel sequence of a peptide, characterized by gelling depending on the pH conditions. Since the peptide can induce coagulation, a composition comprising the peptide can be used for inducing hemostasis.

This application discloses a method and system for monitoring coagulation activity, wherein the method includes: preparing a first mixture comprising a plurality of microparticles, a blood sample, and a matrix within a bioassay kit; preparing a second mixture comprising the first mixture and a reagent within the bioassay kit; and performing at least two optical detections on the second mixture within the bioassay kit, wherein: the first optical detection of the at least two optical detections includes transmitting a first light beam through a first sidewall of the bioassay kit and the second mixture; and the second optical detection of the at least two optical detections includes transmitting a second light beam through a second sidewall of the bioassay kit and the second mixture.

A high-activity blood coagulation factor XI mutant Ala570Thr (A570T), having nucleotide sequences as shown in SEQ ID NOs: 1-4 and an amino acid sequence as shown in SEQ ID NO: 5, is provided. The mutant is resistant to a physiological inhibitor thereof after being activated from a zymogen state to an active enzyme. Therefore, the mutant has a very high blood coagulation activity and a stronger catalytic ability for a non-physiological substrate; and the mutant is applied to the treatment of hemorrhagic diseases, and has good prospects in terms of gene therapy, gene editing and recombinant protein replacement treatments.